dbEM

Protein: INO80B

#	Cell Line/Tumor sample	Tissue of Origin	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587376	LARGE INTESTINE	c.72G>T	p.K24N	COSMIC	NP	NP
2	HN_62624	UPPER AERODIGESTIVE TRACT	c.360A>G	p.P120P	COSMIC	NP	NP
3	LUAD-RT-S01840	LUNG	c.92A>T	p.K31M	COSMIC	NP	NP
4	MZ1-PC	PANCREAS	c.1029G>T	p.T343T	COSMIC	NP	NP
5	OVCAR-5	OVARY	c.996_997insGC	p.P333fs*>12	COSMIC	NP	NP
6	PR-2872	PROSTATE	c.910C>A	p.P304T	COSMIC	NP	NP
7	SWE-21	PROSTATE	c.469G>C	p.E157Q	COSMIC	PASSENGER/OTHER	Probably Damaging
8	TCGA-22-1011-01	LUNG	c.896C>G	p.P299R	COSMIC	NP	Benign
9	TCGA-22-5473-01	LUNG	c.251C>T	p.S84L	COSMIC	PASSENGER/OTHER	Probably Damaging
10	TCGA-35-4122-01	LUNG	c.187G>A	p.G63R	COSMIC	NP	NP
11	TCGA-67-3771-01	LUNG	c.46G>T	p.G16C	COSMIC	NP	NP
12	TCGA-AA-3525-01	LARGE INTESTINE	c.63A>T	p.G21G	COSMIC	NP	NP
13	TCGA-AA-3984-01	LARGE INTESTINE	c.465G>T	p.K155N	COSMIC	NP	NP
14	TCGA-AP-A0LM-01	ENDOMETRIUM	c.481C>T	p.R161W	COSMIC	NP	NP
15	TCGA-AX-A0J0-01	ENDOMETRIUM	c.25G>A	p.A9T	COSMIC	NP	NP
16	TCGA-BH-A0H6-01	BREAST	c.876G>C	p.P292P	COSMIC	NP	NP
17	TCGA-BK-A0C9-01	ENDOMETRIUM	c.411G>A	p.Q137Q	COSMIC	NP	NP
18	TCGA-BS-A0UF-01	ENDOMETRIUM	c.457G>T	p.D153Y	COSMIC	NP	NP
19	TCGA-F5-6465-01	LARGE INTESTINE	c.589G>T	p.E197*	COSMIC	NP	NP
20	WA16	PROSTATE	c.439delG	p.E147fs*40	COSMIC	NP	NP
21	YUPEET	SKIN	c.337G>A	p.D113N	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Expression and CNV data is not present for INO80B!!
Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

Gene essentiality data is not present in COLT database!!
Tertiary structure (+)

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Modelled Structure Structures available in PDB
Structure Domains (+)

1. PFAM domains are not present!!

2. Superfaimly domains are not present!!
Sequence Alignment (+)

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1. Sequence alignment with 1000 genome variations:

2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

4. Sequence alignment with homologus proteins:
  Sequence Profiles (+)

HMM
  With Uniprot database     With Mutants      With 1000 Genome Variants
PSSM
  With Uniprot database     With Mutants      With 1000 Genome Variant
Post Translational Modifications (+)

Post translational modifications are not found!!
Other Databases Link (+)

Proteomics DB COSMIC Gene Atlas STRING PIR

INO80B INO80B INO80B

QuickGO HGNC Ensembl Genome Browser TreeFam UniProt

INO80B INO80B

Expression Atlas Protein Atlas OMIM IntAct PharmGKB

INO80B

Modelled Structure	Structures available in PDB