dbEM

Protein: INO80B

#	Cell Line/Tumor sample	Tissue of Origin	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	587376	LARGE INTESTINE	c.72G>T	p.K24N	COSMIC	NP	NP
2	HN_62624	UPPER AERODIGESTIVE TRACT	c.360A>G	p.P120P	COSMIC	NP	NP
3	LUAD-RT-S01840	LUNG	c.92A>T	p.K31M	COSMIC	NP	NP
4	MZ1-PC	PANCREAS	c.1029G>T	p.T343T	COSMIC	NP	NP
5	OVCAR-5	OVARY	c.996_997insGC	p.P333fs*>12	COSMIC	NP	NP
6	PR-2872	PROSTATE	c.910C>A	p.P304T	COSMIC	NP	NP
7	SWE-21	PROSTATE	c.469G>C	p.E157Q	COSMIC	PASSENGER/OTHER	Probably Damaging
8	TCGA-22-1011-01	LUNG	c.896C>G	p.P299R	COSMIC	NP	Benign
9	TCGA-22-5473-01	LUNG	c.251C>T	p.S84L	COSMIC	PASSENGER/OTHER	Probably Damaging
10	TCGA-35-4122-01	LUNG	c.187G>A	p.G63R	COSMIC	NP	NP
11	TCGA-67-3771-01	LUNG	c.46G>T	p.G16C	COSMIC	NP	NP
12	TCGA-AA-3525-01	LARGE INTESTINE	c.63A>T	p.G21G	COSMIC	NP	NP
13	TCGA-AA-3984-01	LARGE INTESTINE	c.465G>T	p.K155N	COSMIC	NP	NP
14	TCGA-AP-A0LM-01	ENDOMETRIUM	c.481C>T	p.R161W	COSMIC	NP	NP
15	TCGA-AX-A0J0-01	ENDOMETRIUM	c.25G>A	p.A9T	COSMIC	NP	NP
16	TCGA-BH-A0H6-01	BREAST	c.876G>C	p.P292P	COSMIC	NP	NP
17	TCGA-BK-A0C9-01	ENDOMETRIUM	c.411G>A	p.Q137Q	COSMIC	NP	NP
18	TCGA-BS-A0UF-01	ENDOMETRIUM	c.457G>T	p.D153Y	COSMIC	NP	NP
19	TCGA-F5-6465-01	LARGE INTESTINE	c.589G>T	p.E197*	COSMIC	NP	NP
20	WA16	PROSTATE	c.439delG	p.E147fs*40	COSMIC	NP	NP
21	YUPEET	SKIN	c.337G>A	p.D113N	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Expression and CNV data is not present for INO80B!!
Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test
Tertiary structure (+)

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Modelled Structure Structures available in PDB

Structure is not available in PDB
Structure Domains (+)

1. PFAM Domains:

Domain ID Domain Name Start Site End Site E-value
PF04795 PAPA-1 211 293 2.5e-22
PF04438 zf-HIT 305 336 4.4e-07

2. Superfaimly domains are not present!!

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1. Sequence alignment with 1000 genome variations:

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2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

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4. Sequence alignment with homologus proteins:

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Modelled Structure	Structures available in PDB
	Structure is not available in PDB