dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: INO80C |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 LAU50_1 SKIN c.25G>C p.A9P COSMIC NP Possibly Damaging 2 LC_S11 LUNG c.77G>T p.S26I COSMIC NP Possibly Damaging 3 LUAD-RT-S01721 LUNG c.303_305delGAA p.K101delK COSMIC NP NP 4 MB_Exm564 CENTRAL NERVOUS SYSTEM c.32C>G p.T11S COSMIC NP Benign 5 TCGA-05-4415-01 LUNG c.526G>T p.D176Y COSMIC NP Probably Damaging 6 TCGA-85-6561-01 LUNG c.564G>T p.T188T COSMIC NP NP 7 TCGA-A6-6653-01 LARGE INTESTINE c.82T>C p.S28P COSMIC NP Benign 8 TCGA-AZ-6601-01 LARGE INTESTINE c.276C>T p.G92G COSMIC NP NP 9 TCGA-CI-6622-01 LARGE INTESTINE c.563C>T p.T188M COSMIC NP Probably Damaging 10 TCGA-D1-A0ZO-01 ENDOMETRIUM c.19A>T p.I7F COSMIC NP Benign 11 TCGA-D1-A103-01 ENDOMETRIUM c.333C>A p.I111I COSMIC NP NP 12 TCGA-D8-A1XV-01 BREAST c.575C>T p.P192L COSMIC NP Possibly Damaging 13 TCGA-DK-A1AG-01 URINARY TRACT c.9G>A p.A3A COSMIC NP NP 14 TCGA-DS-A1OC-01 CERVIX c.369C>G p.N123K COSMIC NP Possibly Damaging 15 WA15 PROSTATE c.344A>C p.E115A COSMIC NP Probably Damaging 16 WA15 PROSTATE c.371A>C p.D124A COSMIC NP Benign 17 YUHEF SKIN c.511C>T p.R171W COSMIC NP Probably Damaging 18 YUKLAB SKIN c.511C>T p.R171W COSMIC NP Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
