dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: INO80C |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 LAU50_1 SKIN c.25G>C p.A9P COSMIC NP Possibly Damaging 2 LC_S11 LUNG c.77G>T p.S26I COSMIC NP Possibly Damaging 3 LUAD-RT-S01721 LUNG c.303_305delGAA p.K101delK COSMIC NP NP 4 MB_Exm564 CENTRAL NERVOUS SYSTEM c.32C>G p.T11S COSMIC NP Benign 5 TCGA-05-4415-01 LUNG c.526G>T p.D176Y COSMIC NP Probably Damaging 6 TCGA-85-6561-01 LUNG c.564G>T p.T188T COSMIC NP NP 7 TCGA-A6-6653-01 LARGE INTESTINE c.82T>C p.S28P COSMIC NP Benign 8 TCGA-AZ-6601-01 LARGE INTESTINE c.276C>T p.G92G COSMIC NP NP 9 TCGA-CI-6622-01 LARGE INTESTINE c.563C>T p.T188M COSMIC NP Probably Damaging 10 TCGA-D1-A0ZO-01 ENDOMETRIUM c.19A>T p.I7F COSMIC NP Benign 11 TCGA-D1-A103-01 ENDOMETRIUM c.333C>A p.I111I COSMIC NP NP 12 TCGA-D8-A1XV-01 BREAST c.575C>T p.P192L COSMIC NP Possibly Damaging 13 TCGA-DK-A1AG-01 URINARY TRACT c.9G>A p.A3A COSMIC NP NP 14 TCGA-DS-A1OC-01 CERVIX c.369C>G p.N123K COSMIC NP Possibly Damaging 15 WA15 PROSTATE c.344A>C p.E115A COSMIC NP Probably Damaging 16 WA15 PROSTATE c.371A>C p.D124A COSMIC NP Benign 17 YUHEF SKIN c.511C>T p.R171W COSMIC NP Probably Damaging 18 YUKLAB SKIN c.511C>T p.R171W COSMIC NP Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 13 T Phosphorylation 2 21 K Ubiquitylation 3 21 K Ubiquitylation 4 22 K Ubiquitylation 5 22 K Ubiquitylation 6 26 S Phosphorylation 7 37 Y Phosphorylation 8 41 K Ubiquitylation 9 41 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR INO80C INO80C INO80C ENSP00000334473 Q6PI98 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q6PI98 INO80C ENSP00000334473 INO80C Q6PI98 Expression Atlas Protein Atlas OMIM IntAct PharmGKB INO80C ENSP00000334473 NA Q6PI98 PA162392132
