dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: INO80D |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587220 LARGE INTESTINE c.1342C>T p.R448C COSMIC NP NP 2 609 SALIVARY GLAND c.2128C>A p.Q710K COSMIC NP NP 3 631076 LUNG c.1012G>T p.E338* COSMIC NP NP 4 ESO-1481 OESOPHAGUS c.2444C>T p.T815M COSMIC NP NP 5 ESO-916 OESOPHAGUS c.578G>A p.S193N COSMIC NP NP 6 G4 LARGE INTESTINE c.964G>T p.A322S COSMIC NP NP 7 LPJ119 HAEMATOPOIETIC AND LYMPHOID TISSUE c.53C>A p.P18H COSMIC NP NP 8 LPJ119 HAEMATOPOIETIC AND LYMPHOID TISSUE c.57C>G p.N19K COSMIC NP NP 9 LUAD-NYU284 LUNG c.849G>A p.L283L COSMIC NP NP 10 LUAD-RT-S01818 LUNG c.1467G>C p.L489L COSMIC NP NP 11 LUAD-S01356 LUNG c.275C>G p.P92R COSMIC NP NP 12 LUAD-S01357 LUNG c.1258A>T p.K420* COSMIC NP NP 13 LUAD-S01405 LUNG c.183G>C p.V61V COSMIC NP NP 14 PD4601a NS c.2018G>C p.R673T COSMIC NP NP 15 PR-01-1934 PROSTATE c.2387C>G p.S796C COSMIC NP NP 16 T65 ENDOMETRIUM c.1840G>C p.G614R COSMIC NP NP 17 TCGA-05-4430-01 LUNG c.1987A>T p.T663S COSMIC PASSENGER/OTHER Possibly Damaging 18 TCGA-21-1076-01 LUNG c.684A>T p.P228P COSMIC NP NP 19 TCGA-22-4591-01 LUNG c.2631G>T p.Q877H COSMIC NP NP 20 TCGA-24-2298-01 OVARY c.2683A>G p.I895V COSMIC NP NP 21 TCGA-29-1697-01 OVARY c.1787G>T p.G596V COSMIC NP NP 22 TCGA-34-5240-01 LUNG c.2130A>G p.Q710Q COSMIC NP NP 23 TCGA-39-5039-01 LUNG c.1639G>T p.A547S COSMIC NP NP 24 TCGA-50-5946-01 LUNG c.1359C>T p.P453P COSMIC NP NP 25 TCGA-50-5946-02 LUNG c.1359C>T p.P453P COSMIC NP NP 26 TCGA-60-2719-01 LUNG c.555C>T p.F185F COSMIC NP NP 27 TCGA-61-2094-01 OVARY c.2307C>A p.T769T COSMIC NP NP 28 TCGA-69-7765-01 LUNG c.1895G>C p.R632P COSMIC NP NP 29 TCGA-69-7765-01 LUNG c.370G>C p.V124L COSMIC NP NP 30 TCGA-69-7765-01 LUNG c.659G>C p.W220S COSMIC NP NP 31 TCGA-73-4668-01 LUNG c.119C>A p.T40N COSMIC NP NP 32 TCGA-75-6214-01 LUNG c.2254G>T p.A752S COSMIC NP NP 33 TCGA-86-7711-01 LUNG c.1591G>A p.D531N COSMIC NP NP 34 TCGA-97-7938-01 LUNG c.1600G>C p.E534Q COSMIC NP NP 35 TCGA-AA-3710-01 LARGE INTESTINE c.883C>T p.H295Y COSMIC NP NP 36 TCGA-AA-3947-01 LARGE INTESTINE c.275delC p.P92fs*23 COSMIC NP NP 37 TCGA-AA-3950-01 LARGE INTESTINE c.1225delA p.M409fs*5 COSMIC NP NP 38 TCGA-AG-3892-01 LARGE INTESTINE c.2214C>A p.I738I COSMIC NP NP 39 TCGA-AP-A059-01 ENDOMETRIUM c.2362C>T p.L788F COSMIC NP NP 40 TCGA-AP-A0LM-01 ENDOMETRIUM c.545C>T p.A182V COSMIC NP NP 41 TCGA-AX-A05S-01 ENDOMETRIUM c.338_340delCTT p.S113delS COSMIC NP NP 42 TCGA-AX-A05Z-01 ENDOMETRIUM c.1681G>A p.E561K COSMIC NP NP 43 TCGA-AX-A0J1-01 ENDOMETRIUM c.545C>T p.A182V COSMIC NP NP 44 TCGA-AZ-4315-01 LARGE INTESTINE c.545C>T p.A182V COSMIC NP NP 45 TCGA-B5-A0JR-01 ENDOMETRIUM c.608C>T p.T203I COSMIC NP NP 46 TCGA-B5-A11E-01 ENDOMETRIUM c.1640C>A p.A547D COSMIC NP NP 47 TCGA-B5-A11E-01 ENDOMETRIUM c.347C>A p.P116H COSMIC PASSENGER/OTHER Probably Damaging 48 TCGA-B5-A11X-01 ENDOMETRIUM c.1355G>A p.R452Q COSMIC NP NP 49 TCGA-BS-A0UV-01 ENDOMETRIUM c.2331C>T p.G777G COSMIC NP NP 50 TCGA-BS-A0UV-01 ENDOMETRIUM c.640C>T p.P214S COSMIC PASSENGER/OTHER Benign 51 TCGA-CA-6717-01 LARGE INTESTINE c.1413C>T p.S471S COSMIC NP NP 52 TCGA-CJ-5678-01 KIDNEY c.1826G>C p.G609A COSMIC NP NP 53 TCGA-CJ-5681-01 KIDNEY c.16T>C p.F6L COSMIC NP NP 54 TCGA-CK-6746-01 LARGE INTESTINE c.2668C>T p.P890S COSMIC NP NP 55 TCGA-CZ-5464-01 KIDNEY c.1485G>A p.P495P COSMIC NP NP 56 TCGA-D5-6534-01 LARGE INTESTINE c.88G>A p.G30R COSMIC NP NP 57 TCGA-D5-6540-01 LARGE INTESTINE c.1225_1226insA p.M409fs*3 COSMIC NP NP 58 TCGA-D5-6930-01 LARGE INTESTINE c.2613C>T p.S871S COSMIC NP NP 59 TCGA-DK-A1A5-01 URINARY TRACT c.1600G>A p.E534K COSMIC NP NP 60 TCGA-DK-A1AB-01 URINARY TRACT c.985A>T p.I329L COSMIC NP NP 61 TCGA-DM-A1D9-01 LARGE INTESTINE c.15C>T p.A5A COSMIC NP NP 62 TCGA-E9-A1R7-01 BREAST c.2429C>A p.S810Y COSMIC NP NP 63 TCGA-EO-A1Y8-01 ENDOMETRIUM c.1180G>T p.D394Y COSMIC NP NP 64 TCGA-F4-6704-01 LARGE INTESTINE c.1552G>C p.D518H COSMIC NP NP 65 TCGA-FU-A23K-01 CERVIX c.694G>C p.E232Q COSMIC NP NP 66 tumor_4163639 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2324T>C p.L775P COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
