dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: INO80E |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 1T SKIN c.492C>T p.P164P COSMIC NP NP 2 ESO-114 OESOPHAGUS c.55A>G p.K19E COSMIC NP Probably Damaging 3 ESO-717 OESOPHAGUS c.34delA p.K14fs*5 COSMIC NP NP 4 HCC61T LIVER c.608T>C p.L203P COSMIC NP Probably Damaging 5 TCGA-39-5027-01 LUNG c.12G>T p.P4P COSMIC NP NP 6 TCGA-99-8032-01 LUNG c.407C>T p.S136F COSMIC NP Benign 7 TCGA-A6-3809-01 LARGE INTESTINE c.526delC p.D178fs*8 COSMIC NP NP 8 TCGA-A6-6780-01 LARGE INTESTINE c.303delG p.G103fs*28 COSMIC NP NP 9 TCGA-AA-3663-01 LARGE INTESTINE c.624_625insC p.T212fs*16 COSMIC NP NP 10 TCGA-AA-3811-01 LARGE INTESTINE c.625delC p.T212fs*3 COSMIC NP NP 11 TCGA-AD-6964-01 LARGE INTESTINE c.34delA p.K14fs*5 COSMIC NP NP 12 TCGA-AP-A059-01 ENDOMETRIUM c.366C>A p.A122A COSMIC NP NP 13 TCGA-AX-A06H-01 ENDOMETRIUM c.584G>T p.G195V COSMIC NP Possibly Damaging 14 TCGA-AZ-6598-01 LARGE INTESTINE c.625_626delCC p.P211fs*16 COSMIC NP NP 15 TCGA-AZ-6601-01 LARGE INTESTINE c.478C>T p.R160W COSMIC NP Possibly Damaging 16 TCGA-B5-A0JY-01 ENDOMETRIUM c.621G>T p.K207N COSMIC NP Probably Damaging 17 TCGA-CM-6161-01 LARGE INTESTINE c.34delA p.K14fs*5 COSMIC NP NP 18 TCGA-CM-6171-01 LARGE INTESTINE c.624_625insC p.T212fs*16 COSMIC NP NP 19 TCGA-D1-A167-01 ENDOMETRIUM c.299C>T p.P100L COSMIC NP Possibly Damaging 20 TCGA-D5-6540-01 LARGE INTESTINE c.34delA p.K14fs*5 COSMIC NP NP 21 TCGA-EI-6507-01 LARGE INTESTINE c.625delC p.T212fs*3 COSMIC NP NP 22 TCGA-G2-A2EF-01 URINARY TRACT c.28G>C p.D10H COSMIC NP Probably Damaging 23 TCGA-G4-6304-01 LARGE INTESTINE c.425C>A p.P142H COSMIC NP Probably Damaging 24 YUDAB SKIN c.418C>T p.P140S COSMIC NP Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 11 Y Phosphorylation 2 154 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR INO80E INO80E INO80E ENSP00000456073 Q8NBZ0 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q8NBZ0 INO80E ENSP00000456073 INO80E Q8NBZ0 Expression Atlas Protein Atlas OMIM IntAct PharmGKB INO80E ENSP00000456073 NA Q8NBZ0 PA162392174
