dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: JARID2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 22RV1 PROSTATE c.3001G>C p.V1001L CCLE PASSENGER/OTHER Probably Damaging 2 769P KIDNEY c.304G>A p.E102K CCLE PASSENGER/OTHER Benign 3 BICR18 UPPER AERODIGESTIVE TRACT c.357G>A p.Q119Q CCLE NP NP 4 BICR18 UPPER AERODIGESTIVE TRACT c.468T>C p.D156D CCLE NP NP 5 BXPC3 PANCREAS c.718A>G p.K240E CCLE PASSENGER/OTHER Benign 6 DKMG CENTRAL NERVOUS SYSTEM c.3641C>G p.P1214R CCLE PASSENGER/OTHER Possibly Damaging 7 HCC1569 BREAST c.288T>C p.S96S CCLE NP NP 8 HCT15 LARGE INTESTINE c.2960C>T p.P987L CCLE PASSENGER/OTHER Probably Damaging 9 HEC1A ENDOMETRIUM c.3682G>A p.V1228M CCLE PASSENGER/OTHER Possibly Damaging 10 HEC1B ENDOMETRIUM c.3682G>A p.V1228M CCLE PASSENGER/OTHER Possibly Damaging 11 HRT18 LARGE INTESTINE c.2662C>T p.H888Y CCLE PASSENGER/OTHER Probably Damaging 12 JHUEM2 ENDOMETRIUM c.2996G>T p.R999M CCLE PASSENGER/OTHER Probably Damaging 13 LOVO LARGE INTESTINE c.3112A>C p.S1038R CCLE PASSENGER/OTHER Possibly Damaging 14 LS180 LARGE INTESTINE c.643A>C p.T215P CCLE PASSENGER/OTHER Benign 15 LS411N LARGE INTESTINE c.538C>A p.Q180K CCLE PASSENGER/OTHER Possibly Damaging 16 MDAMB435S SKIN c.114G>T p.K38N CCLE PASSENGER/OTHER Benign 17 MDAPCA2B PROSTATE c.255A>C p.A85A CCLE NP NP 18 MOLT13 HAEMATOPOIETIC AND LYMPHOID TISSUE c.698G>A p.R233Q CCLE PASSENGER/OTHER Benign 19 MOLT16 HAEMATOPOIETIC AND LYMPHOID TISSUE c.79C>T p.R27W CCLE PASSENGER/OTHER Probably Damaging 20 NCIH647 LUNG c.2218C>T p.H740Y CCLE PASSENGER/OTHER Probably Damaging 21 NCIH660 PROSTATE c.269C>G p.S90C CCLE PASSENGER/OTHER Probably Damaging 22 NUGC3 STOMACH c.2806C>A p.P936T CCLE PASSENGER/OTHER Probably Damaging 23 OVK18 OVARY c.1817G>A p.R606Q CCLE PASSENGER/OTHER Possibly Damaging 24 REH HAEMATOPOIETIC AND LYMPHOID TISSUE c.3210_3210delA p.A1070fs CCLE NP NP 25 RKO LARGE INTESTINE c.3728C>A p.S1243* CCLE NP NP 26 RL HAEMATOPOIETIC AND LYMPHOID TISSUE c.982G>A p.V328I CCLE PASSENGER/OTHER Benign 27 SNGM ENDOMETRIUM c.2657C>T p.S886L CCLE PASSENGER/OTHER Probably Damaging 28 SNGM ENDOMETRIUM c.3010A>G p.S1004G CCLE PASSENGER/OTHER Possibly Damaging 29 SNU175 LARGE INTESTINE c.2479C>T p.R827* CCLE NP NP 30 SNU1 STOMACH c.1267G>T p.G423W CCLE PASSENGER/OTHER Possibly Damaging 31 SNU81 LARGE INTESTINE c.490C>T p.R164* CCLE NP NP 32 SNUC2A LARGE INTESTINE c.572A>G p.E191G CCLE PASSENGER/OTHER Benign 33 SNUC5 LARGE INTESTINE c.560A>C p.E187A CCLE PASSENGER/OTHER Possibly Damaging 34 SUDHL5 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3661C>T p.R1221C CCLE PASSENGER/OTHER Probably Damaging 35 SW1116 LARGE INTESTINE c.466G>A p.D156N CCLE PASSENGER/OTHER Probably Damaging 36 SW48 LARGE INTESTINE c.1770_1770delC p.I590fs CCLE NP NP 37 SW48 LARGE INTESTINE c.231G>T p.Q77H CCLE PASSENGER/OTHER Benign 38 SW48 LARGE INTESTINE c.2674C>A p.L892I CCLE PASSENGER/OTHER Probably Damaging 39 UMUC3 URINARY TRACT c.782G>C p.R261P CCLE PASSENGER/OTHER Probably Damaging 40 1946219 LUNG c.1649G>T p.G550V COSMIC PASSENGER/OTHER Probably Damaging 41 585208 LUNG c.2166G>T p.E722D COSMIC PASSENGER/OTHER Benign 42 587220 LARGE INTESTINE c.1523C>T p.T508M COSMIC PASSENGER/OTHER Benign 43 587226 LARGE INTESTINE c.2258G>A p.R753H COSMIC PASSENGER/OTHER Probably Damaging 44 587228 LARGE INTESTINE c.1160G>A p.R387H COSMIC PASSENGER/OTHER Probably Damaging 45 587234 LARGE INTESTINE c.2197C>T p.R733C COSMIC PASSENGER/OTHER Probably Damaging 46 587342 LARGE INTESTINE c.1412G>A p.G471D COSMIC PASSENGER/OTHER Benign 47 587376 LARGE INTESTINE c.146C>T p.A49V COSMIC PASSENGER/OTHER Benign 48 587376 LARGE INTESTINE c.497C>A p.S166Y COSMIC PASSENGER/OTHER Probably Damaging 49 ESO-017 OESOPHAGUS c.880C>T p.R294W COSMIC PASSENGER/OTHER Probably Damaging 50 ESO-0292 OESOPHAGUS c.1266delG p.R425fs*36 COSMIC NP NP 51 ESO-1670 OESOPHAGUS c.3364G>A p.G1122R COSMIC PASSENGER/OTHER Possibly Damaging 52 ESO-2143 OESOPHAGUS c.1456A>T p.K486* COSMIC NP NP 53 ESO-721 OESOPHAGUS c.3622G>A p.E1208K COSMIC PASSENGER/OTHER Possibly Damaging 54 ESO-859 OESOPHAGUS c.1266delG p.R425fs*36 COSMIC NP NP 55 ESO-859 OESOPHAGUS c.2719G>A p.G907S COSMIC PASSENGER/OTHER Probably Damaging 56 ESO-859 OESOPHAGUS c.3704C>T p.A1235V COSMIC PASSENGER/OTHER Benign 57 GC6_T STOMACH c.3205G>A p.E1069K COSMIC PASSENGER/OTHER Possibly Damaging 58 HCT-15 LARGE INTESTINE c.1577C>G p.S526C COSMIC PASSENGER/OTHER Probably Damaging 59 HCT-15 LARGE INTESTINE c.2960C>T p.P987L COSMIC PASSENGER/OTHER Probably Damaging 60 HF-23896 LUNG c.1649G>T p.G550V COSMIC PASSENGER/OTHER Probably Damaging 61 ID46 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3005_3006insG p.Q1003fs*25 COSMIC NP NP 62 LUAD-D01603 LUNG c.2263G>T p.E755* COSMIC NP NP 63 LUAD-F00089 LUNG c.815C>T p.A272V COSMIC PASSENGER/OTHER Benign 64 LUAD-NYU284 LUNG c.209G>T p.G70V COSMIC PASSENGER/OTHER Benign 65 LUAD-S01302 LUNG c.3249C>G p.A1083A COSMIC NP NP 66 LUAD-S01315 LUNG c.2543A>G p.Q848R COSMIC PASSENGER/OTHER Probably Damaging 67 LXFL529 LUNG c.1364C>T p.S455L COSMIC PASSENGER/OTHER Benign 68 M14 HAEMATOPOIETIC AND LYMPHOID TISSUE c.114G>T p.K38N COSMIC PASSENGER/OTHER Benign 69 MD-253 CENTRAL NERVOUS SYSTEM c.581A>T p.D194V COSMIC PASSENGER/OTHER Probably Damaging 70 MDA-MB-435 HAEMATOPOIETIC AND LYMPHOID TISSUE c.114G>T p.K38N COSMIC PASSENGER/OTHER Benign 71 MDA-N HAEMATOPOIETIC AND LYMPHOID TISSUE c.114G>T p.K38N COSMIC PASSENGER/OTHER Benign 72 MZ1-PC PANCREAS c.2596G>A p.G866S COSMIC PASSENGER/OTHER Probably Damaging 73 NB07C AUTONOMIC GANGLIA c.246G>T p.K82N COSMIC PASSENGER/OTHER Possibly Damaging 74 NCI-H2126 LUNG c.1617G>A p.S539S COSMIC NP NP 75 RK115_C01 LIVER c.2275G>T p.G759W COSMIC PASSENGER/OTHER Probably Damaging 76 SA069 BREAST c.1858C>T p.R620C COSMIC PASSENGER/OTHER Benign 77 T95 PROSTATE c.651delA p.K217fs*90 COSMIC NP NP 78 TCGA-13-0793-01 OVARY c.1670T>G p.I557S COSMIC PASSENGER/OTHER Benign 79 TCGA-13-0897-01 OVARY c.733G>T p.E245* COSMIC NP NP 80 TCGA-18-3409-01 LUNG c.1179C>T p.L393L COSMIC NP NP 81 TCGA-22-5491-01 LUNG c.2078G>A p.R693Q COSMIC PASSENGER/OTHER Probably Damaging 82 TCGA-25-1326-01 OVARY c.2957C>A p.S986Y COSMIC PASSENGER/OTHER Probably Damaging 83 TCGA-34-5231-01 LUNG c.2634A>C p.P878P COSMIC NP NP 84 TCGA-34-5231-01 LUNG c.3505G>C p.V1169L COSMIC PASSENGER/OTHER Probably Damaging 85 TCGA-37-3783-01 LUNG c.3527G>A p.R1176Q COSMIC PASSENGER/OTHER Probably Damaging 86 TCGA-44-6776-01 LUNG c.453G>T p.K151N COSMIC PASSENGER/OTHER Probably Damaging 87 TCGA-49-6743-01 LUNG c.2167G>C p.V723L COSMIC PASSENGER/OTHER Possibly Damaging 88 TCGA-50-5930-01 LUNG c.2228A>T p.N743I COSMIC PASSENGER/OTHER Benign 89 TCGA-50-5930-01 LUNG c.280G>C p.D94H COSMIC PASSENGER/OTHER Probably Damaging 90 TCGA-50-6590-01 LUNG c.2178G>T p.E726D COSMIC PASSENGER/OTHER Possibly Damaging 91 TCGA-55-6975-01 LUNG c.1787G>T p.R596L COSMIC PASSENGER/OTHER Benign 92 TCGA-55-7727-01 LUNG c.2884G>A p.D962N COSMIC PASSENGER/OTHER Possibly Damaging 93 TCGA-63-5131-01 LUNG c.1502G>A p.R501Q COSMIC PASSENGER/OTHER Probably Damaging 94 TCGA-63-6202-01 LUNG c.1389G>T p.A463A COSMIC NP NP 95 TCGA-67-4679-01 LUNG c.502G>T p.A168S COSMIC PASSENGER/OTHER Probably Damaging 96 TCGA-75-6211-01 LUNG c.1487G>A p.R496K COSMIC PASSENGER/OTHER Possibly Damaging 97 TCGA-78-7150-01 LUNG c.1443G>A p.L481L COSMIC NP NP 98 TCGA-78-7539-01 LUNG c.3527G>A p.R1176Q COSMIC PASSENGER/OTHER Probably Damaging 99 TCGA-86-6851-01 LUNG c.719A>T p.K240I COSMIC PASSENGER/OTHER Possibly Damaging 100 TCGA-86-7711-01 LUNG c.3305C>A p.A1102D COSMIC PASSENGER/OTHER Possibly Damaging 101 TCGA-A5-A0G9-01 ENDOMETRIUM c.2856T>C p.I952I COSMIC NP NP 102 TCGA-A6-5666-01 LARGE INTESTINE c.2956T>C p.S986P COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-A6-6781-01 LARGE INTESTINE c.3287G>A p.R1096H COSMIC PASSENGER/OTHER Probably Damaging 104 TCGA-A8-A08R-01 BREAST c.1100C>G p.P367R COSMIC PASSENGER/OTHER Possibly Damaging 105 TCGA-AA-3517-01 LARGE INTESTINE c.1786C>T p.R596W COSMIC PASSENGER/OTHER Probably Damaging 106 TCGA-AA-3532-01 LARGE INTESTINE c.718A>C p.K240Q COSMIC PASSENGER/OTHER Benign 107 TCGA-AA-3697-01 LARGE INTESTINE c.1617G>T p.S539S COSMIC NP NP 108 TCGA-AA-3715-01 LARGE INTESTINE c.2020C>T p.L674F COSMIC PASSENGER/OTHER Probably Damaging 109 TCGA-AA-3715-01 LARGE INTESTINE c.2993A>G p.H998R COSMIC PASSENGER/OTHER Probably Damaging 110 TCGA-AA-3858-01 LARGE INTESTINE c.1029G>A p.T343T COSMIC NP NP 111 TCGA-AA-3947-01 LARGE INTESTINE c.3577G>A p.V1193I COSMIC PASSENGER/OTHER Probably Damaging 112 TCGA-AA-A00J-01 LARGE INTESTINE c.258C>A p.S86S COSMIC NP NP 113 TCGA-AA-A00R-01 LARGE INTESTINE c.3567T>G p.I1189M COSMIC PASSENGER/OTHER Probably Damaging 114 TCGA-AA-A01S-01 LARGE INTESTINE c.837G>A p.S279S COSMIC NP NP 115 TCGA-AD-6890-01 LARGE INTESTINE c.1497G>A p.P499P COSMIC NP NP 116 TCGA-AG-3599-01 LARGE INTESTINE c.898C>T p.R300W COSMIC PASSENGER/OTHER Probably Damaging 117 TCGA-AG-A002-01 LARGE INTESTINE c.1722C>T p.I574I COSMIC NP NP 118 TCGA-AG-A002-01 LARGE INTESTINE c.2069C>A p.A690D COSMIC PASSENGER/OTHER Probably Damaging 119 TCGA-AG-A002-01 LARGE INTESTINE c.490C>T p.R164* COSMIC NP NP 120 TCGA-AG-A00Y-01 LARGE INTESTINE c.2260T>C p.F754L COSMIC PASSENGER/OTHER Benign 121 TCGA-AG-A014-01 LARGE INTESTINE c.2507G>C p.C836S COSMIC PASSENGER/OTHER Probably Damaging 122 TCGA-AO-A03N-01 BREAST c.3279G>A p.L1093L COSMIC NP NP 123 TCGA-AP-A051-01 ENDOMETRIUM c.141G>T p.Q47H COSMIC PASSENGER/OTHER Possibly Damaging 124 TCGA-AP-A051-01 ENDOMETRIUM c.147G>A p.A49A COSMIC NP NP 125 TCGA-AP-A051-01 ENDOMETRIUM c.3059G>A p.C1020Y COSMIC PASSENGER/OTHER Probably Damaging 126 TCGA-AP-A051-01 ENDOMETRIUM c.553G>T p.V185F COSMIC PASSENGER/OTHER Possibly Damaging 127 TCGA-AP-A051-01 ENDOMETRIUM c.736G>A p.A246T COSMIC PASSENGER/OTHER Benign 128 TCGA-AP-A056-01 ENDOMETRIUM c.490C>T p.R164* COSMIC NP NP 129 TCGA-AP-A059-01 ENDOMETRIUM c.1792G>A p.E598K COSMIC PASSENGER/OTHER Probably Damaging 130 TCGA-AP-A0LD-01 ENDOMETRIUM c.3006G>A p.Q1002Q COSMIC NP NP 131 TCGA-AP-A0LP-01 ENDOMETRIUM c.3661C>T p.R1221C COSMIC PASSENGER/OTHER Probably Damaging 132 TCGA-AU-3779-01 LARGE INTESTINE c.734A>G p.E245G COSMIC PASSENGER/OTHER Benign 133 TCGA-AX-A0J0-01 ENDOMETRIUM c.2262C>T p.F754F COSMIC NP NP 134 TCGA-AX-A0J0-01 ENDOMETRIUM c.2664T>C p.H888H COSMIC NP NP 135 TCGA-AX-A0J1-01 ENDOMETRIUM c.1557C>T p.S519S COSMIC NP NP 136 TCGA-AY-6197-01 LARGE INTESTINE c.1770delC p.P592fs*57 COSMIC NP NP 137 TCGA-AZ-6598-01 LARGE INTESTINE c.1265_1266insG p.R425fs*99 COSMIC NP NP 138 TCGA-AZ-6598-01 LARGE INTESTINE c.3661C>T p.R1221C COSMIC PASSENGER/OTHER Probably Damaging 139 TCGA-B0-4945-01 KIDNEY c.366G>T p.P122P COSMIC NP NP 140 TCGA-B0-5085-01 KIDNEY c.1155A>T p.K385N COSMIC PASSENGER/OTHER Probably Damaging 141 TCGA-B5-A11E-01 ENDOMETRIUM c.2091G>A p.L697L COSMIC NP NP 142 TCGA-B5-A11R-01 ENDOMETRIUM c.1792G>A p.E598K COSMIC PASSENGER/OTHER Probably Damaging 143 TCGA-BG-A0LX-01 ENDOMETRIUM c.3358G>A p.A1120T COSMIC PASSENGER/OTHER Benign 144 TCGA-BG-A0W1-01 ENDOMETRIUM c.1158C>G p.T386T COSMIC NP NP 145 TCGA-BG-A18B-01 ENDOMETRIUM c.1147A>G p.N383D COSMIC PASSENGER/OTHER Possibly Damaging 146 TCGA-BH-A0AZ-01 BREAST c.71C>T p.S24L COSMIC PASSENGER/OTHER Probably Damaging 147 TCGA-BH-A0BW-01 BREAST c.1274G>A p.R425Q COSMIC PASSENGER/OTHER Benign 148 TCGA-BI-A0VR-01 CERVIX c.1509G>A p.T503T COSMIC NP NP 149 TCGA-BS-A0UF-01 ENDOMETRIUM c.2262C>T p.F754F COSMIC NP NP 150 TCGA-BS-A0UF-01 ENDOMETRIUM c.2657C>T p.S886L COSMIC PASSENGER/OTHER Probably Damaging 151 TCGA-CK-6746-01 LARGE INTESTINE c.2022_2023insA p.W677fs*133 COSMIC NP NP 152 TCGA-CM-6162-01 LARGE INTESTINE c.1732C>T p.R578C COSMIC PASSENGER/OTHER Probably Damaging 153 TCGA-CM-6171-01 LARGE INTESTINE c.2399A>G p.E800G COSMIC PASSENGER/OTHER Benign 154 TCGA-D1-A103-01 ENDOMETRIUM c.1727C>T p.S576L COSMIC PASSENGER/OTHER Possibly Damaging 155 TCGA-D1-A16S-01 ENDOMETRIUM c.515G>T p.S172I COSMIC PASSENGER/OTHER Possibly Damaging 156 TCGA-D1-A17D-01 ENDOMETRIUM c.2621G>A p.G874D COSMIC PASSENGER/OTHER Probably Damaging 157 TCGA-D1-A17F-01 ENDOMETRIUM c.3041C>T p.S1014F COSMIC PASSENGER/OTHER Probably Damaging 158 TCGA-D1-A17Q-01 ENDOMETRIUM c.2657C>T p.S886L COSMIC PASSENGER/OTHER Probably Damaging 159 TCGA-D5-6928-01 LARGE INTESTINE c.2289C>T p.G763G COSMIC NP NP 160 TCGA-DI-A0WH-01 ENDOMETRIUM c.2768T>C p.F923S COSMIC PASSENGER/OTHER Probably Damaging 161 TCGA-DM-A1D4-01 LARGE INTESTINE c.733G>T p.E245* COSMIC NP NP 162 TCGA-F4-6856-01 LARGE INTESTINE c.1266delG p.R425fs*36 COSMIC NP NP 163 TCGA-G2-A2EJ-01 URINARY TRACT c.1250C>T p.S417L COSMIC PASSENGER/OTHER Benign 164 TCGA-G4-6315-01 LARGE INTESTINE c.1188G>A p.A396A COSMIC NP NP 165 WA33 PROSTATE c.2148C>G p.H716Q COSMIC PASSENGER/OTHER Possibly Damaging 166 WA48 PROSTATE c.1164A>C p.K388N COSMIC PASSENGER/OTHER Probably Damaging 167 WA56 PROSTATE c.491G>A p.R164Q COSMIC PASSENGER/OTHER Probably Damaging 168 YUFLA SKIN c.1487G>A p.R496K COSMIC PASSENGER/OTHER Possibly Damaging 169 YUFLA SKIN c.1499A>C p.K500T COSMIC PASSENGER/OTHER Possibly Damaging 170 YUNOCA SKIN c.3382A>G p.K1128E COSMIC PASSENGER/OTHER Probably Damaging 171 YURTHE SKIN c.148G>A p.E50K COSMIC PASSENGER/OTHER Benign 172 pfg016T STOMACH c.412delC p.P139fs*168 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Sequence alignment with CCLE mutants:3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
