dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: JMJD4 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 019 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1351C>T p.Q451* COSMIC NP NP 2 019-0047-01TD HAEMATOPOIETIC AND LYMPHOID TISSUE c.1351C>T p.Q451* COSMIC NP NP 3 112T THYROID c.529A>G p.R177G COSMIC PASSENGER/OTHER Benign 4 BN13T LIVER c.638A>G p.D213G COSMIC PASSENGER/OTHER Possibly Damaging 5 BN49T LIVER c.1029G>A p.L343L COSMIC NP NP 6 ESO-601 OESOPHAGUS c.1021C>T p.R341C COSMIC PASSENGER/OTHER Benign 7 HCC47T LIVER c.240G>C p.S80S COSMIC NP NP 8 HCC47T LIVER c.242A>G p.E81G COSMIC PASSENGER/OTHER Benign 9 LC_S46 LUNG c.293A>G p.N98S COSMIC PASSENGER/OTHER Probably Damaging 10 LUAD-RT-S01777 LUNG c.277G>T p.G93C COSMIC PASSENGER/OTHER Possibly Damaging 11 ME044T SKIN c.100G>A p.E34K COSMIC PASSENGER/OTHER Benign 12 OPM2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1030C>G p.Q344E COSMIC PASSENGER/OTHER Benign 13 RK041_C01 LIVER c.1295C>T p.P432L COSMIC PASSENGER/OTHER Benign 14 RK055_C01 LIVER c.719G>T p.R240L COSMIC PASSENGER/OTHER Possibly Damaging 15 TCGA-05-4432-01 LUNG c.499G>T p.E167* COSMIC NP NP 16 TCGA-44-3919-01 LUNG c.843C>G p.L281L COSMIC NP NP 17 TCGA-55-1592-01 LUNG c.1289C>T p.A430V COSMIC PASSENGER/OTHER Benign 18 TCGA-61-2110-01 OVARY c.750G>C p.G250G COSMIC NP NP 19 TCGA-A6-6780-01 LARGE INTESTINE c.1258C>T p.R420C COSMIC PASSENGER/OTHER Benign 20 TCGA-AG-3609-01 LARGE INTESTINE c.546C>T p.L182L COSMIC NP NP 21 TCGA-AP-A0LM-01 ENDOMETRIUM c.674C>T p.A225V COSMIC PASSENGER/OTHER Benign 22 TCGA-AP-A0LM-01 ENDOMETRIUM c.714C>A p.I238I COSMIC NP NP 23 TCGA-AX-A064-01 ENDOMETRIUM c.1172C>T p.A391V COSMIC PASSENGER/OTHER Possibly Damaging 24 TCGA-B5-A0K2-01 ENDOMETRIUM c.1032G>C p.Q344H COSMIC PASSENGER/OTHER Benign 25 TCGA-B5-A11E-01 ENDOMETRIUM c.1183C>T p.L395F COSMIC PASSENGER/OTHER Possibly Damaging 26 TCGA-CW-5581-01 KIDNEY c.621G>A p.W207* COSMIC NP NP 27 TCGA-EI-6507-01 LARGE INTESTINE c.1276G>A p.A426T COSMIC PASSENGER/OTHER Benign 28 TCGA-G9-6363-01 PROSTATE c.1136A>C p.N379T COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
