dbEM

#	Cell Line/Tumor sample	Tissue of Origin	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	08-067	SOFT TISSUE	c.2482C>A	p.L828M	COSMIC	NP	NP
2	587342	LARGE INTESTINE	c.1903C>T	p.L635F	COSMIC	NP	NP
3	BJAB	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1825C>T	p.Q609*	COSMIC	NP	NP
4	Co74	LARGE INTESTINE	c.1009_1023del15	p.E337_E341del	COSMIC	NP	NP
5	DLBCL1057	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.428T>G	p.L143R	COSMIC	PASSENGER/OTHER	Possibly Damaging
6	DLBCL694	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1223G>A	p.C408Y	COSMIC	NP	NP
7	DLBCL759	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2494C>G	p.P832A	COSMIC	NP	NP
8	DLBCL801	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2207A>G	p.Y736C	COSMIC	NP	NP
9	DLBCL831	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.815C>T	p.T272M	COSMIC	NP	NP
10	DLBCL834	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1612C>T	p.R538W	COSMIC	NP	NP
11	ESO-1608	OESOPHAGUS	c.1356G>A	p.L452L	COSMIC	NP	NP
12	HCT-15	LARGE INTESTINE	c.313C>T	p.R105C	COSMIC	PASSENGER/OTHER	Probably Damaging
13	LAU149	SKIN	c.2127C>T	p.S709S	COSMIC	NP	NP
14	LC_C15	LUNG	c.33C>G	p.S11R	COSMIC	PASSENGER/OTHER	Benign
15	LC_C21	LUNG	c.2304G>T	p.Q768H	COSMIC	NP	NP
16	LC_C21	LUNG	c.2305G>C	p.V769L	COSMIC	NP	NP
17	LUAD-QY22Z	LUNG	c.1761delA	p.T590fs*4	COSMIC	NP	NP
18	NB-1110	AUTONOMIC GANGLIA	c.316C>T	p.R106C	COSMIC	PASSENGER/OTHER	Probably Damaging
19	PD4594a	NS	c.799G>A	p.E267K	COSMIC	PASSENGER/OTHER	Possibly Damaging
20	PR-00-1165	PROSTATE	c.954C>T	p.T318T	COSMIC	NP	NP
21	RCK8	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.2207A>G	p.Y736C	COSMIC	NP	NP
22	SK-MEL-28	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.1723C>T	p.L575F	COSMIC	NP	NP
23	TCGA-24-2289-01	OVARY	c.1880G>C	p.S627T	COSMIC	NP	NP
24	TCGA-49-4486-01	LUNG	c.2684C>T	p.P895L	COSMIC	NP	NP
25	TCGA-55-6712-01	LUNG	c.321G>A	p.L107L	COSMIC	NP	NP
26	TCGA-60-2698-01	LUNG	c.2757C>T	p.T919T	COSMIC	NP	NP
27	TCGA-66-2773-01	LUNG	c.1855G>A	p.E619K	COSMIC	NP	NP
28	TCGA-69-7974-01	LUNG	c.1003G>C	p.A335P	COSMIC	NP	NP
29	TCGA-75-5126-01	LUNG	c.2688C>A	p.F896L	COSMIC	NP	NP
30	TCGA-A3-3374-01	KIDNEY	c.127C>T	p.R43W	COSMIC	PASSENGER/OTHER	Probably Damaging
31	TCGA-A5-A0GB-01	ENDOMETRIUM	c.1467C>T	p.F489F	COSMIC	NP	NP
32	TCGA-A5-A0VP-01	ENDOMETRIUM	c.816G>A	p.T272T	COSMIC	NP	NP
33	TCGA-A6-6781-01	LARGE INTESTINE	c.513G>A	p.A171A	COSMIC	NP	NP
34	TCGA-AA-3492-01	LARGE INTESTINE	c.2575C>T	p.L859L	COSMIC	NP	NP
35	TCGA-AA-3821-01	LARGE INTESTINE	c.1153G>A	p.V385I	COSMIC	NP	NP
36	TCGA-AA-3877-01	LARGE INTESTINE	c.199T>C	p.W67R	COSMIC	PASSENGER/OTHER	Probably Damaging
37	TCGA-AA-A00N-01	LARGE INTESTINE	c.785_786insT	p.V263fs*5	COSMIC	NP	NP
38	TCGA-AA-A010-01	LARGE INTESTINE	c.2146C>A	p.L716M	COSMIC	NP	NP
39	TCGA-AP-A051-01	ENDOMETRIUM	c.188C>T	p.A63V	COSMIC	PASSENGER/OTHER	Probably Damaging
40	TCGA-AP-A059-01	ENDOMETRIUM	c.1246G>A	p.V416M	COSMIC	NP	NP
41	TCGA-AP-A059-01	ENDOMETRIUM	c.1643C>T	p.A548V	COSMIC	NP	NP
42	TCGA-AP-A059-01	ENDOMETRIUM	c.403C>A	p.L135M	COSMIC	PASSENGER/OTHER	Probably Damaging
43	TCGA-AP-A0LE-01	ENDOMETRIUM	c.814C>T	p.P272S	COSMIC	CANCER	Probably Damaging
44	TCGA-AP-A0LF-01	ENDOMETRIUM	c.2888C>A	p.S963Y	COSMIC	NP	NP
45	TCGA-AP-A0LM-01	ENDOMETRIUM	c.1625C>A	p.S542Y	COSMIC	NP	NP
46	TCGA-AP-A0LM-01	ENDOMETRIUM	c.607C>T	p.R203W	COSMIC	PASSENGER/OTHER	Probably Damaging
47	TCGA-AX-A0J1-01	ENDOMETRIUM	c.2799C>T	p.S933S	COSMIC	NP	NP
48	TCGA-B0-5075-01	KIDNEY	c.212A>G	p.Y71C	COSMIC	PASSENGER/OTHER	Probably Damaging
49	TCGA-B0-5077-01	KIDNEY	c.1855G>A	p.E619K	COSMIC	NP	NP
50	TCGA-B0-5098-01	KIDNEY	c.784T>C	p.S262P	COSMIC	NP	NP
51	TCGA-B5-A11E-01	ENDOMETRIUM	c.889G>A	p.D297N	COSMIC	PASSENGER/OTHER	Probably Damaging
52	TCGA-B5-A11E-01	ENDOMETRIUM	c.989C>T	p.A330V	COSMIC	NP	NP
53	TCGA-BS-A0TA-01	ENDOMETRIUM	c.1078C>T	p.Q360*	COSMIC	NP	NP
54	TCGA-BS-A0UF-01	ENDOMETRIUM	c.1452C>T	p.A484A	COSMIC	NP	NP
55	TCGA-CA-6716-01	LARGE INTESTINE	c.1674C>T	p.C558C	COSMIC	NP	NP
56	TCGA-CA-6717-01	LARGE INTESTINE	c.2587C>T	p.R863W	COSMIC	NP	NP
57	TCGA-CF-A1HS-01	URINARY TRACT	c.2382G>T	p.W794C	COSMIC	NP	NP
58	TCGA-D1-A103-01	ENDOMETRIUM	c.333C>T	p.F111F	COSMIC	NP	NP
59	TCGA-D1-A103-01	ENDOMETRIUM	c.790C>T	p.R264W	COSMIC	PASSENGER/OTHER	Probably Damaging
60	TCGA-D1-A160-01	ENDOMETRIUM	c.384G>A	p.V128V	COSMIC	NP	NP
61	TCGA-D1-A167-01	ENDOMETRIUM	c.778C>T	p.R260C	COSMIC	PASSENGER/OTHER	Benign
62	TCGA-DM-A1D4-01	LARGE INTESTINE	c.1736C>A	p.P579Q	COSMIC	NP	NP
63	TCGA-EI-6508-01	LARGE INTESTINE	c.755G>A	p.R252H	COSMIC	NP	NP
64	TCGA-EJ-5508-01	PROSTATE	c.1094G>A	p.R365H	COSMIC	NP	NP
65	TCGA-F4-6856-01	LARGE INTESTINE	c.1916C>T	p.A639V	COSMIC	NP	NP
66	TCGA-G4-6588-01	LARGE INTESTINE	c.2094C>T	p.Y698Y	COSMIC	NP	NP
67	TCGA-G4-6588-01	LARGE INTESTINE	c.53C>T	p.A18V	COSMIC	PASSENGER/OTHER	Benign
68	TCGA-GV-A3JZ-01	URINARY TRACT	c.937G>C	p.D313H	COSMIC	NP	NP
69	WA7	PROSTATE	c.1250G>A	p.G417D	COSMIC	NP	NP
70	YUAKER	SKIN	c.208C>T	p.P70S	COSMIC	PASSENGER/OTHER	Benign
71	YUWAND	SKIN	c.2107C>T	p.P703S	COSMIC	NP	NP
72	ccRCC-52	KIDNEY	c.2425C>A	p.H809N	COSMIC	NP	NP

*NP: Not Predicted

Domain ID	Domain Name	Start Site	End Site	E-value
PF13621	Cupin_8	40	297	4.2e-75

Domain ID	Start Site	End Site	E-value
0047105	22	307	1.65e-55

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
JMJD7	JMJD7	JMJD7	ENSP00000380467	P0C870
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
P0C870	JMJD7	ENSP00000380467	JMJD7	P0C870
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
JMJD7	ENSP00000380467	NA	P0C870	PA162392530

dbEM

Protein: JMJD7

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)

Modelled Structure	Structures available in PDB