dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: JMJD8 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 HCC2157 BREAST c.910A>G p.I304V COSMIC PASSENGER/OTHER Benign 2 TARGET-30-PAPWFY AUTONOMIC GANGLIA c.316delG p.A106fs*62 COSMIC NP NP 3 TCGA-CM-5861-01 LARGE INTESTINE c.911T>C p.I304T COSMIC PASSENGER/OTHER Possibly Damaging 4 TCGA-G4-6588-01 LARGE INTESTINE c.884C>T p.P295L COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
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Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
