dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: KAT2A |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 112461 LUNG c.2129G>C p.G710A COSMIC PASSENGER/OTHER Probably Damaging 2 447 UPPER AERODIGESTIVE TRACT c.2281G>A p.E761K COSMIC PASSENGER/OTHER Probably Damaging 3 587220 LARGE INTESTINE c.751C>T p.R251W COSMIC PASSENGER/OTHER Benign 4 587376 LARGE INTESTINE c.595T>G p.F199V COSMIC PASSENGER/OTHER Benign 5 ESO-117 OESOPHAGUS c.359G>A p.C120Y COSMIC PASSENGER/OTHER Probably Damaging 6 HCT-116 LARGE INTESTINE c.511C>T p.R171* COSMIC NP NP 7 ICGC_MB18 CENTRAL NERVOUS SYSTEM c.509A>G p.N170S COSMIC PASSENGER/OTHER Benign 8 LAU50_1 SKIN c.628C>T p.L210L COSMIC NP NP 9 LAU50_2 SKIN c.628C>T p.L210L COSMIC NP NP 10 LUAD_E00565 LUNG c.2457C>T p.S819S COSMIC NP NP 11 NB-0230 AUTONOMIC GANGLIA c.370A>G p.K124E COSMIC PASSENGER/OTHER Probably Damaging 12 PR-09-3566 PROSTATE c.398G>A p.R133H COSMIC PASSENGER/OTHER Probably Damaging 13 SWE-4A PROSTATE c.531G>T p.V177V COSMIC NP NP 14 TCGA-44-5644-01 LUNG c.2414G>A p.R805H COSMIC PASSENGER/OTHER Probably Damaging 15 TCGA-55-6969-01 LUNG c.2364G>T p.V788V COSMIC NP NP 16 TCGA-60-2709-01 LUNG c.1627G>A p.V543I COSMIC PASSENGER/OTHER Benign 17 TCGA-64-5775-01 LUNG c.930C>T p.R310R COSMIC NP NP 18 TCGA-A1-A0SB-01 BREAST c.471C>T p.H157H COSMIC NP NP 19 TCGA-A2-A0T0-01 BREAST c.2022C>T p.I674I COSMIC NP NP 20 TCGA-A5-A0GH-01 ENDOMETRIUM c.1527G>A p.T509T COSMIC NP NP 21 TCGA-AA-3492-01 LARGE INTESTINE c.1306C>T p.L436F COSMIC PASSENGER/OTHER Benign 22 TCGA-AA-3660-01 LARGE INTESTINE c.2042G>A p.R681H COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-AA-A01R-01 LARGE INTESTINE c.1345C>T p.R449C COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-AD-5900-01 LARGE INTESTINE c.1598G>A p.R533H COSMIC PASSENGER/OTHER Probably Damaging 25 TCGA-AJ-A23M-01 ENDOMETRIUM c.2249C>T p.A750V COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-AK-3447-01 KIDNEY c.1973G>A p.R658H COSMIC PASSENGER/OTHER Benign 27 TCGA-AP-A054-01 ENDOMETRIUM c.1993T>C p.S665P COSMIC PASSENGER/OTHER Possibly Damaging 28 TCGA-AP-A056-01 ENDOMETRIUM c.753G>A p.R251R COSMIC NP NP 29 TCGA-AP-A059-01 ENDOMETRIUM c.1745C>A p.T582N COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-AP-A05N-01 ENDOMETRIUM c.1148C>A p.P383H COSMIC PASSENGER/OTHER Possibly Damaging 31 TCGA-AP-A0LM-01 ENDOMETRIUM c.1442C>T p.S481L COSMIC PASSENGER/OTHER Possibly Damaging 32 TCGA-AX-A0J1-01 ENDOMETRIUM c.1486C>T p.R496C COSMIC PASSENGER/OTHER Probably Damaging 33 TCGA-B5-A11Y-01 ENDOMETRIUM c.1852G>A p.A618T COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-BS-A0TE-01 ENDOMETRIUM c.1455C>T p.A485A COSMIC NP NP 35 TCGA-BS-A0TJ-01 ENDOMETRIUM c.1197G>A p.A399A COSMIC NP NP 36 TCGA-BS-A0UF-01 ENDOMETRIUM c.1577T>C p.V526A COSMIC PASSENGER/OTHER Probably Damaging 37 TCGA-BT-A20J-01 URINARY TRACT c.2495G>C p.G832A COSMIC PASSENGER/OTHER Benign 38 TCGA-CF-A1HR-01 URINARY TRACT c.756G>C p.Q252H COSMIC PASSENGER/OTHER Possibly Damaging 39 TCGA-CH-5765-01 PROSTATE c.370A>G p.K124E COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-CH-5765-01 PROSTATE c.375C>A p.N125K COSMIC PASSENGER/OTHER Benign 41 TCGA-CM-5868-01 LARGE INTESTINE c.2415C>T p.R805R COSMIC NP NP 42 TCGA-D1-A103-01 ENDOMETRIUM c.1935C>T p.Y645Y COSMIC NP NP 43 TCGA-DK-A1A6-01 URINARY TRACT c.2353C>T p.R785C COSMIC PASSENGER/OTHER Probably Damaging 44 TCGA-DS-A1OC-01 CERVIX c.2088C>T p.F696F COSMIC NP NP 45 TCGA-F4-6570-01 LARGE INTESTINE c.2097C>T p.G699G COSMIC NP NP 46 TCGA-F4-6704-01 LARGE INTESTINE c.1778A>T p.H593L COSMIC PASSENGER/OTHER Probably Damaging 47 ccRCC-5 KIDNEY c.762delG p.M254fs*166 COSMIC NP NP 48 ccRCC-60 KIDNEY c.1400C>G p.T467S COSMIC PASSENGER/OTHER Benign 49 ccRCC-76 KIDNEY c.1264G>T p.D422Y COSMIC PASSENGER/OTHER Possibly Damaging 50 ccRCC-96 KIDNEY c.1237G>A p.G413R COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 289 K Ubiquitylation 2 734 Y Phosphorylation 3 734 Y Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR KAT2A KAT2A KAT2A ENSP00000225916 Q92830 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q92830 KAT2A ENSP00000225916 KAT2A Q92830 Expression Atlas Protein Atlas OMIM IntAct PharmGKB KAT2A ENSP00000225916 602301 Q92830 PA162392664
