dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: KAT5 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 8031632 PANCREAS c.1115A>T p.Y372F COSMIC NP NP 2 DLBCL-PatientK HAEMATOPOIETIC AND LYMPHOID TISSUE c.1330C>T p.L444F COSMIC NP NP 3 LUAD-F00368 LUNG c.181C>G p.L61V COSMIC NP NP 4 S00501 LUNG c.493C>G p.Q165E COSMIC NP NP 5 SF268 CENTRAL NERVOUS SYSTEM c.1019G>C p.R340P COSMIC NP NP 6 SWE-7 PROSTATE c.1245C>G p.G415G COSMIC NP NP 7 TCGA-18-3409-01 LUNG c.375G>A p.E125E COSMIC NP NP 8 TCGA-22-4604-01 LUNG c.956G>T p.R319L COSMIC NP Probably Damaging 9 TCGA-44-2665-01 LUNG c.984C>G p.R328R COSMIC NP NP 10 TCGA-78-7146-01 LUNG c.1211T>C p.L404P COSMIC NP NP 11 TCGA-A5-A0GX-01 ENDOMETRIUM c.1257C>A p.I419I COSMIC NP NP 12 TCGA-AA-3510-01 LARGE INTESTINE c.1585G>A p.D529N COSMIC NP NP 13 TCGA-AA-3525-01 LARGE INTESTINE c.1383G>A p.G461G COSMIC NP NP 14 TCGA-AA-3667-01 LARGE INTESTINE c.130delT p.C44fs*22 COSMIC NP NP 15 TCGA-AA-3715-01 LARGE INTESTINE c.328A>G p.T110A COSMIC NP NP 16 TCGA-AA-3947-01 LARGE INTESTINE c.911G>A p.R304H COSMIC NP NP 17 TCGA-AG-3901-01 LARGE INTESTINE c.813C>T p.G271G COSMIC NP NP 18 TCGA-AG-A002-01 LARGE INTESTINE c.757C>T p.R253* COSMIC NP NP 19 TCGA-AP-A056-01 ENDOMETRIUM c.983G>A p.R328H COSMIC NP NP 20 TCGA-AP-A059-01 ENDOMETRIUM c.975G>T p.E325D COSMIC NP Probably Damaging 21 TCGA-AX-A0J1-01 ENDOMETRIUM c.540G>A p.T180T COSMIC NP NP 22 TCGA-AX-A1C8-01 ENDOMETRIUM c.730C>T p.R244C COSMIC NP NP 23 TCGA-B5-A11E-01 ENDOMETRIUM c.1414A>C p.I472L COSMIC NP NP 24 TCGA-B5-A11R-01 ENDOMETRIUM c.1456G>A p.E486K COSMIC NP NP 25 TCGA-BS-A0UV-01 ENDOMETRIUM c.1128G>T p.E376D COSMIC NP NP 26 TCGA-CA-6717-01 LARGE INTESTINE c.1539C>T p.I513I COSMIC NP NP 27 TCGA-CJ-4913-01 KIDNEY c.1153G>T p.V385L COSMIC NP Probably Damaging 28 TCGA-D1-A103-01 ENDOMETRIUM c.498G>A p.P166P COSMIC NP NP 29 TCGA-D1-A103-01 ENDOMETRIUM c.629G>A p.R210H COSMIC NP NP 30 TCGA-D1-A17M-01 ENDOMETRIUM c.1282G>A p.V428M COSMIC NP NP 31 TCGA-EI-6507-01 LARGE INTESTINE c.593delC p.P199fs*47 COSMIC NP NP 32 TCGA-GD-A2C5-01 URINARY TRACT c.545G>A p.R182Q COSMIC NP NP 33 YUKLAB SKIN c.1132G>A p.D378N COSMIC NP NP 34 pfg016T STOMACH c.1423A>G p.N475D COSMIC NP NP 35 pfg019T STOMACH c.359G>A p.R120H COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 155 S Phosphorylation 2 199 S Phosphorylation 3 202 S Phosphorylation 4 230 K Acetylation 5 268 K Acetylation 6 282 K Acetylation 7 35 K Ubiquitylation 8 430 K Sumoylation 9 430 K Sumoylation 10 451 K Sumoylation 11 451 K Sumoylation 12 472 Y Phosphorylation 13 52 K Acetylation 14 52 K Acetylation 15 86 S Phosphorylation 16 86 S Phosphorylation (CCNB1) 17 86 S Phosphorylation (CDK1) 18 86 S Phosphorylation 19 90 S Phosphorylation 20 90 S Phosphorylation (CCNB1) 21 90 S Phosphorylation (CDK1) 22 90 S Phosphorylation 23 90 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR KAT5 KAT5 KAT5 ENSP00000340330 Q92993 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q92993 KAT5 ENSP00000340330 KAT5 Q92993 Expression Atlas Protein Atlas OMIM IntAct PharmGKB KAT5 ENSP00000340330 601409 Q92993 PA162392746
