dbEM
A Database of Epigenetic Modifiers
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Cite:
Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes.
Sci Rep. 6:19340.
Protein: KAT6B
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Mutation Data (+)
#
Cell Line/Tumor sample
Tissue of Origin
cDNA change
Protein change
Source
FATHMM Prediction
PolyPhen2 Prediction
*NP: Not Predicted
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Copy number variation and expression profile (+)
Expression and CNV data is not present for KAT6B!!
Gene Essentiality Data (+)
Note:
Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.
Gene essentiality data is not present in COLT database!!
Tertiary structure (+)
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Modelled Structure
Structures available in PDB
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Structure Domains (+)
1. PFAM domains are not present!!
2. Superfaimly domains are not present!!
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from
here
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1. Variants are not present in 1000 Genomes!!
2. Mutants are not present in CCLE!!
4. Mutants are not present in COSMIC!!
4. Sequence alignment with homologus proteins:
Sequence Profiles (+)
HMM
With Uniprot database
With Mutants
With 1000 Genome Variants
PSSM
With Uniprot database
With Mutants
With 1000 Genome Variant
Post Translational Modifications (+)
Post translational modifications are not found!!
Other Databases Link (+)
Proteomics DB
COSMIC
Gene Atlas
STRING
PIR
KAT6B
KAT6B
KAT6B
QuickGO
HGNC
Ensembl Genome Browser
TreeFam
UniProt
KAT6B
KAT6B
Expression Atlas
Protein Atlas
OMIM
IntAct
PharmGKB
KAT6B
CSIR-IMTECH
Raghava's Group