dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: KDM1B |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 24T SKIN c.470T>C p.I157T COSMIC PASSENGER/OTHER Benign 2 587238 LARGE INTESTINE c.1459G>A p.A487T COSMIC NP NP 3 587270 LARGE INTESTINE c.89C>A p.A30E COSMIC PASSENGER/OTHER Benign 4 CCRF-CEM HAEMATOPOIETIC AND LYMPHOID TISSUE c.862C>T p.R288* COSMIC NP NP 5 ESO-874 OESOPHAGUS c.371A>C p.E124A COSMIC PASSENGER/OTHER Probably Damaging 6 HN_62756 UPPER AERODIGESTIVE TRACT c.1614G>A p.V538V COSMIC NP NP 7 LAU165 SKIN c.1559A>G p.Y520C COSMIC NP NP 8 LC_C24 LUNG c.953T>C p.M318T COSMIC NP NP 9 LUAD-B00416 LUNG c.1075G>A p.D359N COSMIC NP NP 10 LUAD-B02515 LUNG c.1447G>A p.G483R COSMIC NP NP 11 PD4137a BREAST c.1458C>T p.V486V COSMIC NP NP 12 SA093 BREAST c.466G>A p.E156K COSMIC PASSENGER/OTHER Benign 13 SWE-21 PROSTATE c.287T>G p.F96C COSMIC PASSENGER/OTHER Probably Damaging 14 TCGA-05-4432-01 LUNG c.417G>T p.W139C COSMIC PASSENGER/OTHER Probably Damaging 15 TCGA-22-1011-01 LUNG c.1064C>T p.A355V COSMIC NP NP 16 TCGA-50-5933-01 LUNG c.1065A>G p.A355A COSMIC NP NP 17 TCGA-55-7574-01 LUNG c.1765G>A p.A589T COSMIC NP NP 18 TCGA-66-2755-01 LUNG c.1203G>T p.Q401H COSMIC NP NP 19 TCGA-A5-A0VP-01 ENDOMETRIUM c.1728A>G p.A576A COSMIC NP NP 20 TCGA-A6-2676-01 LARGE INTESTINE c.185G>C p.C62S COSMIC PASSENGER/OTHER Benign 21 TCGA-AA-3713-01 LARGE INTESTINE c.34G>T p.A12S COSMIC PASSENGER/OTHER Benign 22 TCGA-AA-3811-01 LARGE INTESTINE c.230G>A p.G77D COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-AA-3984-01 LARGE INTESTINE c.1740C>T p.G580G COSMIC NP NP 24 TCGA-AA-3984-01 LARGE INTESTINE c.863G>A p.R288Q COSMIC NP NP 25 TCGA-AA-A00A-01 LARGE INTESTINE c.543C>T p.T181T COSMIC NP NP 26 TCGA-AA-A00R-01 LARGE INTESTINE c.54G>A p.P18P COSMIC NP NP 27 TCGA-AP-A051-01 ENDOMETRIUM c.312G>T p.K104N COSMIC PASSENGER/OTHER Probably Damaging 28 TCGA-AP-A051-01 ENDOMETRIUM c.507C>T p.C169C COSMIC NP NP 29 TCGA-AP-A054-01 ENDOMETRIUM c.1639T>C p.Y547H COSMIC NP NP 30 TCGA-AP-A056-01 ENDOMETRIUM c.996C>A p.F332L COSMIC NP NP 31 TCGA-AP-A059-01 ENDOMETRIUM c.996C>A p.F332L COSMIC NP NP 32 TCGA-AP-A05H-01 ENDOMETRIUM c.1638C>A p.A546A COSMIC NP NP 33 TCGA-AP-A0LM-01 ENDOMETRIUM c.1376G>A p.R459Q COSMIC NP NP 34 TCGA-AX-A0IS-01 ENDOMETRIUM c.639C>T p.C213C COSMIC NP NP 35 TCGA-AX-A0J1-01 ENDOMETRIUM c.617G>T p.R206L COSMIC NP NP 36 TCGA-B5-A11J-01 ENDOMETRIUM c.1426G>A p.V476M COSMIC NP NP 37 TCGA-BG-A0M4-01 ENDOMETRIUM c.861C>T p.G287G COSMIC NP NP 38 TCGA-BS-A0UV-01 ENDOMETRIUM c.996C>A p.F332L COSMIC NP NP 39 TCGA-D1-A15X-01 ENDOMETRIUM c.369C>T p.T123T COSMIC NP NP 40 TCGA-D1-A165-01 ENDOMETRIUM c.120G>A p.E40E COSMIC NP NP 41 TCGA-D1-A17M-01 ENDOMETRIUM c.640G>A p.V214I COSMIC NP NP 42 TCGA-D1-A17Q-01 ENDOMETRIUM c.502C>T p.R168* COSMIC NP NP 43 TCGA-DK-A1AD-01 URINARY TRACT c.1242G>A p.K414K COSMIC NP NP 44 TCGA-DK-A3IK-01 URINARY TRACT c.1233G>A p.L411L COSMIC NP NP 45 TCGA-EY-A1GS-01 ENDOMETRIUM c.1166A>C p.Q389P COSMIC NP NP 46 TCGA-F4-6570-01 LARGE INTESTINE c.682G>T p.G228C COSMIC NP NP 47 TCGA-GV-A3QI-01 URINARY TRACT c.1720A>G p.T574A COSMIC NP NP 48 YUAKER SKIN c.1631G>A p.G544E COSMIC NP Probably Damaging 49 YUKLAB SKIN c.562C>T p.P188S COSMIC PASSENGER/OTHER Possibly Damaging 50 YULAPE SKIN c.409C>T p.P137S COSMIC PASSENGER/OTHER Probably Damaging 51 cSCCP8 SKIN c.1322G>T p.S441I COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
