dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: KDM3A |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 1946219 LUNG c.1595A>T p.Q532L COSMIC PASSENGER/OTHER Probably Damaging 2 587376 LARGE INTESTINE c.1429T>G p.L477V COSMIC PASSENGER/OTHER Benign 3 587376 LARGE INTESTINE c.1468A>C p.K490Q COSMIC PASSENGER/OTHER Possibly Damaging 4 587376 LARGE INTESTINE c.2703G>T p.K901N COSMIC PASSENGER/OTHER Possibly Damaging 5 587376 LARGE INTESTINE c.52C>A p.L18I COSMIC PASSENGER/OTHER Possibly Damaging 6 91T SKIN c.1000C>T p.P334S COSMIC PASSENGER/OTHER Probably Damaging 7 Br27P CENTRAL NERVOUS SYSTEM c.1400G>A p.C467Y COSMIC PASSENGER/OTHER Possibly Damaging 8 ESO-536 OESOPHAGUS c.2288A>G p.K763R COSMIC PASSENGER/OTHER Benign 9 GC8_T STOMACH c.1559T>A p.L520H COSMIC PASSENGER/OTHER Probably Damaging 10 GC8_T STOMACH c.1560C>T p.L520L COSMIC NP NP 11 GC8_T STOMACH c.3561A>G p.E1187E COSMIC NP NP 12 HCC100T LIVER c.99G>A p.W33* COSMIC NP NP 13 HCC2218 BREAST c.559G>C p.D187H COSMIC PASSENGER/OTHER Probably Damaging 14 HCC2998 LARGE INTESTINE c.2491A>C p.N831H COSMIC PASSENGER/OTHER Possibly Damaging 15 HCC61T LIVER c.3203A>C p.N1068T COSMIC PASSENGER/OTHER Probably Damaging 16 HCC75T LIVER c.3490_3491insT p.E1165fs*1 COSMIC NP NP 17 HF-23896 LUNG c.1595A>T p.Q532L COSMIC PASSENGER/OTHER Probably Damaging 18 HN_62624 UPPER AERODIGESTIVE TRACT c.3371C>G p.S1124C COSMIC PASSENGER/OTHER Probably Damaging 19 HN_63080 UPPER AERODIGESTIVE TRACT c.3851C>A p.S1284* COSMIC NP NP 20 LOXIMVI HAEMATOPOIETIC AND LYMPHOID TISSUE c.2188G>T p.A730S COSMIC PASSENGER/OTHER Possibly Damaging 21 LUAD-CHTN-MAD06-00668 LUNG c.16G>T p.G6* COSMIC NP NP 22 LUAD-CHTN-MAD06-00668 LUNG c.44G>T p.R15M COSMIC PASSENGER/OTHER Benign 23 LUAD-NYU704 LUNG c.2591C>T p.T864I COSMIC PASSENGER/OTHER Benign 24 LUAD-S01357 LUNG c.329delA p.Q110fs*5 COSMIC NP NP 25 LUAD-S01482 LUNG c.2219C>A p.S740Y COSMIC PASSENGER/OTHER Probably Damaging 26 P53 LIVER c.1663C>T p.R555C COSMIC PASSENGER/OTHER Probably Damaging 27 PD4128a BREAST c.1351_1358delAATGCACC p.N451fs*8 COSMIC NP NP 28 PD4601a NS c.3371C>G p.S1124C COSMIC PASSENGER/OTHER Probably Damaging 29 RK126_C01 LIVER c.1439G>T p.R480L COSMIC PASSENGER/OTHER Benign 30 SJMB008 CENTRAL NERVOUS SYSTEM c.2012A>G p.N671S COSMIC PASSENGER/OTHER Probably Damaging 31 T155 ENDOMETRIUM c.277A>C p.N93H COSMIC PASSENGER/OTHER Benign 32 T90 PROSTATE c.3267C>G p.N1089K COSMIC PASSENGER/OTHER Benign 33 TCGA-13-1498-01 OVARY c.2628C>G p.P876P COSMIC NP NP 34 TCGA-18-3407-01 LUNG c.2229G>A p.A743A COSMIC NP NP 35 TCGA-18-3411-01 LUNG c.713T>A p.L238Q COSMIC PASSENGER/OTHER Probably Damaging 36 TCGA-22-4593-01 LUNG c.3001G>T p.E1001* COSMIC NP NP 37 TCGA-39-5031-01 LUNG c.3933G>A p.L1311L COSMIC NP NP 38 TCGA-44-2656-01 LUNG c.3685C>T p.Q1229* COSMIC NP NP 39 TCGA-44-2656-01 LUNG c.448A>G p.I150V COSMIC PASSENGER/OTHER Benign 40 TCGA-66-2778-01 LUNG c.1122G>A p.Q374Q COSMIC NP NP 41 TCGA-A3-3324-01 KIDNEY c.1468A>C p.K490Q COSMIC PASSENGER/OTHER Possibly Damaging 42 TCGA-A5-A0GA-01 ENDOMETRIUM c.561C>A p.D187E COSMIC PASSENGER/OTHER Possibly Damaging 43 TCGA-A6-2672-01 LARGE INTESTINE c.614A>G p.Q205R COSMIC PASSENGER/OTHER Probably Damaging 44 TCGA-A6-3809-01 LARGE INTESTINE c.863C>A p.P288H COSMIC PASSENGER/OTHER Benign 45 TCGA-AA-3525-01 LARGE INTESTINE c.1091G>A p.C364Y COSMIC PASSENGER/OTHER Possibly Damaging 46 TCGA-AA-3861-01 LARGE INTESTINE c.441G>A p.L147L COSMIC NP NP 47 TCGA-AA-3864-01 LARGE INTESTINE c.1582G>A p.E528K COSMIC PASSENGER/OTHER Probably Damaging 48 TCGA-AA-3966-01 LARGE INTESTINE c.993delA p.I333fs*18 COSMIC NP NP 49 TCGA-AA-A00R-01 LARGE INTESTINE c.784C>T p.R262C COSMIC PASSENGER/OTHER Probably Damaging 50 TCGA-AA-A022-01 LARGE INTESTINE c.255G>A p.R85R COSMIC NP NP 51 TCGA-AD-6965-01 LARGE INTESTINE c.1401T>C p.C467C COSMIC NP NP 52 TCGA-AF-6136-01 LARGE INTESTINE c.1401T>C p.C467C COSMIC NP NP 53 TCGA-AG-A002-01 LARGE INTESTINE c.1432G>T p.A478S COSMIC PASSENGER/OTHER Benign 54 TCGA-AO-A03V-01 BREAST c.2486G>A p.S829N COSMIC PASSENGER/OTHER Possibly Damaging 55 TCGA-AP-A059-01 ENDOMETRIUM c.1438C>T p.R480* COSMIC NP NP 56 TCGA-AP-A059-01 ENDOMETRIUM c.2948A>C p.H983P COSMIC PASSENGER/OTHER Benign 57 TCGA-AX-A05Z-01 ENDOMETRIUM c.366A>C p.K122N COSMIC PASSENGER/OTHER Probably Damaging 58 TCGA-AX-A05Z-01 ENDOMETRIUM c.505G>T p.E169* COSMIC NP NP 59 TCGA-AX-A05Z-01 ENDOMETRIUM c.956C>T p.T319I COSMIC PASSENGER/OTHER Possibly Damaging 60 TCGA-AX-A064-01 ENDOMETRIUM c.2656C>A p.R886R COSMIC NP NP 61 TCGA-AX-A0IU-01 ENDOMETRIUM c.3205A>T p.I1069F COSMIC PASSENGER/OTHER Probably Damaging 62 TCGA-AX-A0J0-01 ENDOMETRIUM c.2533A>C p.I845L COSMIC PASSENGER/OTHER Benign 63 TCGA-AX-A0J1-01 ENDOMETRIUM c.2778G>A p.R926R COSMIC NP NP 64 TCGA-AX-A0J1-01 ENDOMETRIUM c.3661C>T p.R1221C COSMIC PASSENGER/OTHER Probably Damaging 65 TCGA-AZ-4315-01 LARGE INTESTINE c.3097C>T p.R1033C COSMIC PASSENGER/OTHER Probably Damaging 66 TCGA-AZ-4315-01 LARGE INTESTINE c.3896T>C p.V1299A COSMIC PASSENGER/OTHER Probably Damaging 67 TCGA-AZ-6599-01 LARGE INTESTINE c.2627C>A p.P876H COSMIC PASSENGER/OTHER Probably Damaging 68 TCGA-B0-5110-01 KIDNEY c.3307G>A p.A1103T COSMIC PASSENGER/OTHER Probably Damaging 69 TCGA-B0-5116-01 KIDNEY c.3639T>C p.Y1213Y COSMIC NP NP 70 TCGA-B2-5633-01 KIDNEY c.3915A>G p.K1305K COSMIC NP NP 71 TCGA-B5-A0JY-01 ENDOMETRIUM c.224G>T p.R75I COSMIC PASSENGER/OTHER Possibly Damaging 72 TCGA-B5-A11E-01 ENDOMETRIUM c.1974T>C p.V658V COSMIC NP NP 73 TCGA-BH-A1FC-01 BREAST c.2640C>T p.N880N COSMIC NP NP 74 TCGA-BP-5168-01 KIDNEY c.2876A>G p.N959S COSMIC PASSENGER/OTHER Benign 75 TCGA-BT-A3PH-01 URINARY TRACT c.2421C>T p.A807A COSMIC NP NP 76 TCGA-CA-6717-01 LARGE INTESTINE c.2628C>T p.P876P COSMIC NP NP 77 TCGA-CA-6717-01 LARGE INTESTINE c.2848C>T p.R950C COSMIC PASSENGER/OTHER Probably Damaging 78 TCGA-CA-6717-01 LARGE INTESTINE c.3747T>C p.H1249H COSMIC NP NP 79 TCGA-CA-6717-01 LARGE INTESTINE c.672C>T p.N224N COSMIC NP NP 80 TCGA-CF-A3MG-01 URINARY TRACT c.376G>A p.G126R COSMIC PASSENGER/OTHER Probably Damaging 81 TCGA-CM-5344-01 LARGE INTESTINE c.1401T>C p.C467C COSMIC NP NP 82 TCGA-D1-A103-01 ENDOMETRIUM c.505G>T p.E169* COSMIC NP NP 83 TCGA-D1-A103-01 ENDOMETRIUM c.727G>T p.V243F COSMIC PASSENGER/OTHER Possibly Damaging 84 TCGA-D1-A17M-01 ENDOMETRIUM c.187G>T p.V63L COSMIC PASSENGER/OTHER Benign 85 TCGA-D8-A1JL-01 BREAST c.3685C>G p.Q1229E COSMIC PASSENGER/OTHER Benign 86 TCGA-D8-A27L-01 BREAST c.2647G>A p.G883S COSMIC PASSENGER/OTHER Possibly Damaging 87 TCGA-E2-A150-01 BREAST c.2279T>G p.L760R COSMIC PASSENGER/OTHER Possibly Damaging 88 TCGA-E5-A2PC-01 URINARY TRACT c.70G>A p.D24N COSMIC PASSENGER/OTHER Benign 89 TCGA-EJ-5516-01 PROSTATE c.2143C>T p.H715Y COSMIC PASSENGER/OTHER Probably Damaging 90 TCGA-F4-6856-01 LARGE INTESTINE c.1664G>A p.R555H COSMIC PASSENGER/OTHER Probably Damaging 91 TCGA-FI-A2EW-01 ENDOMETRIUM c.2951A>C p.K984T COSMIC PASSENGER/OTHER Benign 92 TCGA-G4-6626-01 LARGE INTESTINE c.2626C>T p.P876S COSMIC PASSENGER/OTHER Benign 93 WA37 PROSTATE c.2422G>C p.G808R COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score. -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
-
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
-
Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
