dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: KDM4A |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 18T SKIN c.454C>T p.R152W COSMIC PASSENGER/OTHER Probably Damaging 2 585208 LUNG c.1903G>T p.A635S COSMIC PASSENGER/OTHER Benign 3 587228 LARGE INTESTINE c.1873A>G p.T625A COSMIC PASSENGER/OTHER Benign 4 587376 LARGE INTESTINE c.2516G>T p.R839I COSMIC PASSENGER/OTHER Benign 5 BN36T LIVER c.3030T>C p.L1010L COSMIC NP NP 6 ESOSCC162T OESOPHAGUS c.1684A>T p.R562W COSMIC PASSENGER/OTHER Possibly Damaging 7 H1703 LUNG c.1529C>G p.S510C COSMIC PASSENGER/OTHER Benign 8 HCC102T LIVER c.2728A>G p.K910E COSMIC PASSENGER/OTHER Probably Damaging 9 HCC91T LIVER c.1258C>A p.L420M COSMIC PASSENGER/OTHER Possibly Damaging 10 HN_62237 UPPER AERODIGESTIVE TRACT c.337G>A p.E113K COSMIC PASSENGER/OTHER Benign 11 HN_62237 UPPER AERODIGESTIVE TRACT c.8C>T p.S3F COSMIC PASSENGER/OTHER Possibly Damaging 12 HN_62505 UPPER AERODIGESTIVE TRACT c.1626C>T p.L542L COSMIC NP NP 13 HN_62686 UPPER AERODIGESTIVE TRACT c.1984G>T p.A662S COSMIC PASSENGER/OTHER Benign 14 HOP-62 LUNG c.2035C>T p.Q679* COSMIC NP NP 15 LAU108 SKIN c.1944T>A p.P648P COSMIC NP NP 16 LC_S51 LUNG c.2308delG p.A770fs*2 COSMIC NP NP 17 LUAD-B01970 LUNG c.2231G>A p.R744Q COSMIC PASSENGER/OTHER Benign 18 M14 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3041T>C p.V1014A COSMIC PASSENGER/OTHER Possibly Damaging 19 ME015T SKIN c.716G>A p.R239H COSMIC PASSENGER/OTHER Probably Damaging 20 PD4093a BREAST c.866C>T p.T289I COSMIC PASSENGER/OTHER Probably Damaging 21 PR-09-5702 PROSTATE c.2613C>A p.D871E COSMIC PASSENGER/OTHER Probably Damaging 22 RK019_C01 LIVER c.2362G>T p.A788S COSMIC PASSENGER/OTHER Possibly Damaging 23 RK019_C01 LIVER c.2363C>T p.A788V COSMIC PASSENGER/OTHER Possibly Damaging 24 S00936 LUNG c.1303G>A p.A435T COSMIC PASSENGER/OTHER Benign 25 S01563 LUNG c.1602A>T p.R534R COSMIC NP NP 26 SWE-12 PROSTATE c.412G>A p.G138S COSMIC PASSENGER/OTHER Possibly Damaging 27 TCGA-34-2600-01 LUNG c.352G>T p.E118* COSMIC NP NP 28 TCGA-34-5927-01 LUNG c.2843G>C p.S948T COSMIC PASSENGER/OTHER Possibly Damaging 29 TCGA-36-2530-01 OVARY c.1283C>T p.T428M COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-44-2656-01 LUNG c.1702G>A p.A568T COSMIC PASSENGER/OTHER Benign 31 TCGA-44-7670-01 LUNG c.520C>A p.P174T COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-50-5930-01 LUNG c.2570A>T p.H857L COSMIC CANCER Probably Damaging 33 TCGA-60-2713-01 LUNG c.1672G>C p.E558Q COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-70-6722-01 LUNG c.259A>G p.I87V COSMIC PASSENGER/OTHER Benign 35 TCGA-A5-A0G9-01 ENDOMETRIUM c.1429G>A p.E477K COSMIC PASSENGER/OTHER Benign 36 TCGA-A6-3809-01 LARGE INTESTINE c.157T>G p.W53G COSMIC PASSENGER/OTHER Possibly Damaging 37 TCGA-A6-5659-01 LARGE INTESTINE c.4G>A p.A2T COSMIC PASSENGER/OTHER Benign 38 TCGA-A8-A06O-01 BREAST c.1043C>T p.P348L COSMIC PASSENGER/OTHER Probably Damaging 39 TCGA-A8-A09I-01 BREAST c.1276G>A p.E426K COSMIC PASSENGER/OTHER Benign 40 TCGA-AA-3811-01 LARGE INTESTINE c.429G>A p.K143K COSMIC NP NP 41 TCGA-AA-3877-01 LARGE INTESTINE c.2733C>T p.N911N COSMIC NP NP 42 TCGA-AA-3947-01 LARGE INTESTINE c.352G>A p.E118K COSMIC PASSENGER/OTHER Probably Damaging 43 TCGA-AD-6548-01 LARGE INTESTINE c.3087T>A p.I1029I COSMIC NP NP 44 TCGA-AG-A002-01 LARGE INTESTINE c.3038G>T p.R1013I COSMIC PASSENGER/OTHER Probably Damaging 45 TCGA-AG-A025-01 LARGE INTESTINE c.328C>T p.R110C COSMIC PASSENGER/OTHER Probably Damaging 46 TCGA-AP-A051-01 ENDOMETRIUM c.1199G>A p.R400Q COSMIC PASSENGER/OTHER Probably Damaging 47 TCGA-AP-A051-01 ENDOMETRIUM c.3182C>T p.A1061V COSMIC PASSENGER/OTHER Probably Damaging 48 TCGA-AP-A0LM-01 ENDOMETRIUM c.3073C>T p.R1025C COSMIC PASSENGER/OTHER Probably Damaging 49 TCGA-AR-A1AX-01 BREAST c.1495C>T p.L499F COSMIC PASSENGER/OTHER Possibly Damaging 50 TCGA-AU-6004-01 LARGE INTESTINE c.676delT p.F227fs*16 COSMIC NP NP 51 TCGA-AX-A05Z-01 ENDOMETRIUM c.1790G>A p.R597H COSMIC PASSENGER/OTHER Probably Damaging 52 TCGA-AX-A05Z-01 ENDOMETRIUM c.3073C>T p.R1025C COSMIC PASSENGER/OTHER Probably Damaging 53 TCGA-AZ-4315-01 LARGE INTESTINE c.962T>C p.V321A COSMIC PASSENGER/OTHER Probably Damaging 54 TCGA-AZ-6601-01 LARGE INTESTINE c.2778C>A p.T926T COSMIC NP NP 55 TCGA-B2-4099-01 KIDNEY c.606T>C p.F202F COSMIC NP NP 56 TCGA-B5-A0JY-01 ENDOMETRIUM c.2138C>T p.S713L COSMIC PASSENGER/OTHER Benign 57 TCGA-B5-A11E-01 ENDOMETRIUM c.83G>A p.S28N COSMIC PASSENGER/OTHER Benign 58 TCGA-BH-A0DG-01 BREAST c.383A>G p.N128S COSMIC PASSENGER/OTHER Benign 59 TCGA-BP-4163-01 KIDNEY c.1935G>C p.Q645H COSMIC PASSENGER/OTHER Probably Damaging 60 TCGA-CL-5918-01 LARGE INTESTINE c.144T>C p.V48V COSMIC NP NP 61 TCGA-D1-A0ZS-01 ENDOMETRIUM c.955G>A p.V319M COSMIC PASSENGER/OTHER Probably Damaging 62 TCGA-D1-A103-01 ENDOMETRIUM c.1940G>A p.R647Q COSMIC PASSENGER/OTHER Probably Damaging 63 TCGA-D1-A17D-01 ENDOMETRIUM c.2474G>A p.R825H COSMIC PASSENGER/OTHER Probably Damaging 64 TCGA-D5-6930-01 LARGE INTESTINE c.1699G>A p.A567T COSMIC PASSENGER/OTHER Benign 65 TCGA-D5-6930-01 LARGE INTESTINE c.356G>A p.R119Q COSMIC PASSENGER/OTHER Probably Damaging 66 TCGA-DC-5337-01 LARGE INTESTINE c.795A>G p.G265G COSMIC NP NP 67 TCGA-DK-A1A5-01 URINARY TRACT c.3094G>A p.E1032K COSMIC PASSENGER/OTHER Probably Damaging 68 TCGA-DS-A0VN-01 CERVIX c.2294G>A p.R765Q COSMIC PASSENGER/OTHER Possibly Damaging 69 YUWAND SKIN c.2513A>G p.K838R COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
