dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: KDM4C |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 09-12737 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3124A>G p.T1042A COSMIC PASSENGER/OTHER Benign 2 1946219 LUNG c.1948C>T p.L650L COSMIC NP NP 3 587336 LARGE INTESTINE c.2651C>T p.T884M COSMIC PASSENGER/OTHER Probably Damaging 4 587336 LARGE INTESTINE c.658C>T p.R220* COSMIC NP NP 5 587342 LARGE INTESTINE c.2167G>A p.V723I COSMIC PASSENGER/OTHER Benign 6 587376 LARGE INTESTINE c.802G>T p.E268* COSMIC NP NP 7 8033610 PANCREAS c.2025C>T p.V675V COSMIC NP NP 8 CLL152 HAEMATOPOIETIC AND LYMPHOID TISSUE c.519A>T p.V173V COSMIC NP NP 9 DLBCL-PatientC HAEMATOPOIETIC AND LYMPHOID TISSUE c.2380A>G p.T794A COSMIC PASSENGER/OTHER Benign 10 HCC31T LIVER c.286G>T p.V96L COSMIC PASSENGER/OTHER Benign 11 HCC71T LIVER c.3146A>C p.Q1049P COSMIC PASSENGER/OTHER Possibly Damaging 12 HN_62506 UPPER AERODIGESTIVE TRACT c.1050A>G p.P350P COSMIC NP NP 13 ICGC_0067 PANCREAS c.2025C>T p.V675V COSMIC NP NP 14 KM12 LARGE INTESTINE c.3107C>T p.A1036V COSMIC PASSENGER/OTHER Benign 15 LAU50_1 SKIN c.2778C>T p.I926I COSMIC NP NP 16 LAU50_2 SKIN c.2778C>T p.I926I COSMIC NP NP 17 LC_C9 LUNG c.1233G>C p.K411N COSMIC PASSENGER/OTHER Benign 18 LUAD-E00918 LUNG c.2104C>T p.P702S COSMIC PASSENGER/OTHER Probably Damaging 19 LUAD-FH5PJ LUNG c.513G>T p.E171D COSMIC PASSENGER/OTHER Benign 20 LUAD-NYU1219 LUNG c.1492G>A p.E498K COSMIC PASSENGER/OTHER Benign 21 LUAD_E00565 LUNG c.1520G>C p.W507S COSMIC PASSENGER/OTHER Benign 22 LUAD_E00565 LUNG c.2131G>T p.G711* COSMIC NP NP 23 PD6754a NS c.2301A>G p.Q767Q COSMIC NP NP 24 S00472 LUNG c.1589G>C p.S530T COSMIC PASSENGER/OTHER Benign 25 SJMB016 CENTRAL NERVOUS SYSTEM c.843delT p.F281fs*35 COSMIC NP NP 26 SJMB016 CENTRAL NERVOUS SYSTEM c.845A>T p.N282I COSMIC PASSENGER/OTHER Probably Damaging 27 SJMB043 CENTRAL NERVOUS SYSTEM c.3125C>A p.T1042N COSMIC PASSENGER/OTHER Possibly Damaging 28 SJMB087 CENTRAL NERVOUS SYSTEM c.2939G>C p.R980T COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-18-3407-01 LUNG c.3054G>T p.G1018G COSMIC NP NP 30 TCGA-20-1686-01 OVARY c.2034G>A p.S678S COSMIC NP NP 31 TCGA-24-2293-01 OVARY c.2352A>T p.E784D COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-33-4532-01 LUNG c.1301C>T p.S434F COSMIC PASSENGER/OTHER Benign 33 TCGA-33-4566-01 LUNG c.1936G>T p.A646S COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-34-5928-01 LUNG c.1260G>A p.V420V COSMIC NP NP 35 TCGA-35-4123-01 LUNG c.2344G>C p.V782L COSMIC PASSENGER/OTHER Benign 36 TCGA-38-4632-01 LUNG c.408A>T p.A136A COSMIC NP NP 37 TCGA-44-7660-01 LUNG c.1766A>T p.Q589L COSMIC PASSENGER/OTHER Benign 38 TCGA-44-8119-01 LUNG c.300G>T p.R100S COSMIC PASSENGER/OTHER Possibly Damaging 39 TCGA-50-5045-01 LUNG c.2293C>T p.L765F COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-50-6594-01 LUNG c.2372C>T p.P791L COSMIC PASSENGER/OTHER Benign 41 TCGA-55-8089-01 LUNG c.3120C>A p.Y1040* COSMIC NP NP 42 TCGA-63-5128-01 LUNG c.2083G>T p.E695* COSMIC NP NP 43 TCGA-69-7980-01 LUNG c.753A>G p.V251V COSMIC NP NP 44 TCGA-73-4668-01 LUNG c.851G>T p.G284V COSMIC PASSENGER/OTHER Probably Damaging 45 TCGA-75-5147-01 LUNG c.1557G>C p.E519D COSMIC PASSENGER/OTHER Possibly Damaging 46 TCGA-78-7155-01 LUNG c.1932C>T p.H644H COSMIC NP NP 47 TCGA-78-7539-01 LUNG c.1497A>T p.K499N COSMIC PASSENGER/OTHER Benign 48 TCGA-91-6849-01 LUNG c.1614C>T p.G538G COSMIC NP NP 49 TCGA-A2-A0CU-01 BREAST c.84G>A p.E28E COSMIC NP NP 50 TCGA-A2-A0YH-01 BREAST c.690A>T p.P230P COSMIC NP NP 51 TCGA-A5-A0VP-01 ENDOMETRIUM c.2343G>A p.A781A COSMIC NP NP 52 TCGA-A6-2672-01 LARGE INTESTINE c.1715G>A p.R572H COSMIC PASSENGER/OTHER Possibly Damaging 53 TCGA-A6-6141-01 LARGE INTESTINE c.1186G>A p.D396N COSMIC PASSENGER/OTHER Benign 54 TCGA-A8-A07P-01 BREAST c.362G>A p.R121H COSMIC PASSENGER/OTHER Probably Damaging 55 TCGA-AA-3502-01 LARGE INTESTINE c.1392A>T p.I464I COSMIC NP NP 56 TCGA-AA-3549-01 LARGE INTESTINE c.155C>T p.P52L COSMIC PASSENGER/OTHER Probably Damaging 57 TCGA-AA-3663-01 LARGE INTESTINE c.2303C>T p.T768M COSMIC PASSENGER/OTHER Probably Damaging 58 TCGA-AA-3712-01 LARGE INTESTINE c.2352A>G p.E784E COSMIC NP NP 59 TCGA-AA-3811-01 LARGE INTESTINE c.2640C>T p.S880S COSMIC NP NP 60 TCGA-AA-3984-01 LARGE INTESTINE c.375G>T p.K125N COSMIC PASSENGER/OTHER Probably Damaging 61 TCGA-AA-A01R-01 LARGE INTESTINE c.2608G>A p.V870M COSMIC PASSENGER/OTHER Benign 62 TCGA-AA-A022-01 LARGE INTESTINE c.658C>T p.R220* COSMIC NP NP 63 TCGA-AG-A002-01 LARGE INTESTINE c.2029A>G p.T677A COSMIC PASSENGER/OTHER Benign 64 TCGA-AG-A002-01 LARGE INTESTINE c.659G>A p.R220Q COSMIC PASSENGER/OTHER Probably Damaging 65 TCGA-AP-A051-01 ENDOMETRIUM c.472G>A p.V158I COSMIC PASSENGER/OTHER Benign 66 TCGA-AP-A056-01 ENDOMETRIUM c.2156C>G p.A719G COSMIC PASSENGER/OTHER Possibly Damaging 67 TCGA-AP-A059-01 ENDOMETRIUM c.1320G>T p.V440V COSMIC NP NP 68 TCGA-AP-A059-01 ENDOMETRIUM c.180C>T p.C60C COSMIC NP NP 69 TCGA-AP-A0LM-01 ENDOMETRIUM c.173G>T p.R58I COSMIC PASSENGER/OTHER Benign 70 TCGA-AP-A0LM-01 ENDOMETRIUM c.1841C>T p.A614V COSMIC PASSENGER/OTHER Probably Damaging 71 TCGA-AP-A0LM-01 ENDOMETRIUM c.1868C>T p.T623M COSMIC PASSENGER/OTHER Probably Damaging 72 TCGA-AP-A0LM-01 ENDOMETRIUM c.2885T>C p.I962T COSMIC PASSENGER/OTHER Benign 73 TCGA-AU-6004-01 LARGE INTESTINE c.2352A>G p.E784E COSMIC NP NP 74 TCGA-AX-A05U-01 ENDOMETRIUM c.3108C>T p.A1036A COSMIC NP NP 75 TCGA-AX-A05Z-01 ENDOMETRIUM c.2356C>T p.R786* COSMIC NP NP 76 TCGA-AX-A0J0-01 ENDOMETRIUM c.2412G>A p.Q804Q COSMIC NP NP 77 TCGA-B0-4945-01 KIDNEY c.90C>A p.N30K COSMIC PASSENGER/OTHER Probably Damaging 78 TCGA-B5-A0JY-01 ENDOMETRIUM c.1494G>T p.E498D COSMIC PASSENGER/OTHER Benign 79 TCGA-B5-A0JY-01 ENDOMETRIUM c.802G>A p.E268K COSMIC PASSENGER/OTHER Probably Damaging 80 TCGA-B5-A0JZ-01 ENDOMETRIUM c.2249C>T p.A750V COSMIC PASSENGER/OTHER Benign 81 TCGA-B5-A11E-01 ENDOMETRIUM c.1136C>T p.T379I COSMIC PASSENGER/OTHER Benign 82 TCGA-B5-A11E-01 ENDOMETRIUM c.2137A>C p.S713R COSMIC PASSENGER/OTHER Probably Damaging 83 TCGA-B8-4622-01 KIDNEY c.2250G>A p.A750A COSMIC NP NP 84 TCGA-BH-A0BG-01 BREAST c.1888G>T p.A630S COSMIC PASSENGER/OTHER Probably Damaging 85 TCGA-BS-A0UV-01 ENDOMETRIUM c.1869G>A p.T623T COSMIC NP NP 86 TCGA-CJ-5675-01 KIDNEY c.492A>G p.E164E COSMIC NP NP 87 TCGA-CZ-5459-01 KIDNEY c.2160G>A p.K720K COSMIC NP NP 88 TCGA-D1-A0ZU-01 ENDOMETRIUM c.2661G>A p.T887T COSMIC NP NP 89 TCGA-D1-A103-01 ENDOMETRIUM c.2778C>T p.I926I COSMIC NP NP 90 TCGA-D1-A103-01 ENDOMETRIUM c.362G>A p.R121H COSMIC PASSENGER/OTHER Probably Damaging 91 TCGA-D1-A16N-01 ENDOMETRIUM c.886G>T p.V296F COSMIC PASSENGER/OTHER Possibly Damaging 92 TCGA-D1-A17H-01 ENDOMETRIUM c.1602C>A p.S534R COSMIC PASSENGER/OTHER Benign 93 TCGA-D8-A1JK-01 BREAST c.1439T>A p.I480K COSMIC PASSENGER/OTHER Benign 94 TCGA-D8-A1X6-01 BREAST c.145G>C p.V49L COSMIC PASSENGER/OTHER Benign 95 TCGA-DK-A1AC-01 URINARY TRACT c.3059G>C p.R1020T COSMIC PASSENGER/OTHER Benign 96 TCGA-DK-A3IM-01 URINARY TRACT c.2547G>A p.E849E COSMIC NP NP 97 TCGA-DM-A1D8-01 LARGE INTESTINE c.2352A>G p.E784E COSMIC NP NP 98 TCGA-DS-A0VM-01 CERVIX c.389T>C p.V130A COSMIC PASSENGER/OTHER Probably Damaging 99 TCGA-E2-A14S-01 BREAST c.1186G>A p.D396N COSMIC PASSENGER/OTHER Benign 100 TCGA-G4-6588-01 LARGE INTESTINE c.1148C>A p.P383H COSMIC PASSENGER/OTHER Benign 101 YUBAN SKIN c.640C>T p.P214S COSMIC PASSENGER/OTHER Probably Damaging 102 YUDAB SKIN c.2293C>T p.L765F COSMIC PASSENGER/OTHER Probably Damaging 103 YUDEXA SKIN c.1987G>A p.E663K COSMIC PASSENGER/OTHER Benign 104 YURUS SKIN c.2767C>T p.P923S COSMIC PASSENGER/OTHER Probably Damaging 105 ccRCC-97 KIDNEY c.2386A>G p.I796V COSMIC PASSENGER/OTHER Benign 106 pfg016T STOMACH c.681_682insT p.S231fs*7 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
