dbEM

Protein: KMT2A

Mutation Data (+)

# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction

*NP: Not Predicted
Copy number variation and expression profile (+)

Expression and CNV data is not present for KMT2A!!
Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

Gene essentiality data is not present in COLT database!!

Tertiary structure (+)

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Modelled Structure	Structures available in PDB
	2AGH, 2J2S, 2JYI, 2KKF, 2KU7, 2KYU, 2LXS, 2LXT, 2MSR, 2W5Y, 2W5Z, 3EG6, 3EMH, 3LQH, 3LQI, 3LQJ, 3P4F, 3U85, 3U88, 4ESG, 4GQ6, 4NW3,

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PB011202	Pfam-B_11202	1021	1086	6.1e-43
PF02008	zf-CXXC	1148	1194	3.4e-13
PB003525	Pfam-B_3525	1397	1449	2.4e-09
PB004447	Pfam-B_4447	1471	1563	5.1e-14
PF00628	PHD	1481	1532	3.4e-08
PF00628	PHD	1568	1626	3.1e-08
PF13771	zf-HC5HC2H	1900	1978	8.1e-15
PF05964	FYRN	2023	2072	4.4e-16
PF05965	FYRC	3667	3749	7.3e-24
PF00856	SET	3840	3944	7.6e-24

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0048183	3824	3966	5.10e-48
0050474	1467	1537	1.48e-11
0050470	1567	1635	1.93e-10
0047674	1704	1768	5.49e-06
0050472	1428	1480	9.08e-04

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Mutants are not present in CCLE!!

4. Mutants are not present in COSMIC!!

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

  Sequence Profiles (+)

HMM
  With Uniprot database     With Mutants      With 1000 Genome Variants
PSSM
  With Uniprot database     With Mutants      With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type
1	1056	S	Phosphorylation
2	1056	S	Phosphorylation
3	1130	K	Acetylation
4	1130	K	Acetylation
5	1235	K	Acetylation
6	1235	K	Acetylation
7	1241	S	Phosphorylation
8	1241	S	Phosphorylation
9	136	S	Phosphorylation
10	136	S	Phosphorylation
11	1376	T	Phosphorylation
12	153	S	Phosphorylation
13	153	S	Phosphorylation
14	161	S	Phosphorylation
15	165	S	Phosphorylation
16	167	S	Phosphorylation
17	1682	S	Phosphorylation
18	1684	S	Phosphorylation
19	1685	S	Phosphorylation
20	1837	S	Phosphorylation
21	1837	S	Phosphorylation
22	1839	T	Phosphorylation
23	1839	T	Phosphorylation
24	1845	T	Phosphorylation
25	1845	T	Phosphorylation
26	1858	S	Phosphorylation
27	1858	S	Phosphorylation
28	197	S	Phosphorylation
29	197	S	Phosphorylation
30	202	S	Phosphorylation
31	202	S	Phosphorylation
32	2094	T	Phosphorylation
33	2098	S	Phosphorylation
34	2098	S	Phosphorylation
35	2147	T	Phosphorylation
36	2147	T	Phosphorylation
37	2149	S	Phosphorylation
38	2151	S	Phosphorylation
39	2151	S	Phosphorylation
40	2153	T	Phosphorylation
41	2153	T	Phosphorylation
42	216	K	Ubiquitylation
43	216	K	Ubiquitylation
44	2196	S	Phosphorylation
45	2198	S	Phosphorylation
46	2199	S	Phosphorylation
47	2199	S	Phosphorylation
48	220	K	Ubiquitylation
49	220	K	Ubiquitylation
50	2201	S	Phosphorylation
51	2201	S	Phosphorylation
52	221	K	Ubiquitylation
53	221	K	Ubiquitylation
54	2388	S	Phosphorylation
55	2391	S	Phosphorylation
56	2525	T	Phosphorylation
57	2525	T	Phosphorylation
58	2666	D	Proteolytic Cleavage
59	268	T	Phosphorylation
60	2691	S	Phosphorylation
61	2691	S	Phosphorylation
62	2718	D	Proteolytic Cleavage
63	2724	T	Phosphorylation
64	2724	T	Phosphorylation
65	2726	S	Phosphorylation
66	2726	S	Phosphorylation
67	2729	S	Phosphorylation
68	2729	S	Phosphorylation
69	2750	T	Phosphorylation
70	279	S	Phosphorylation
71	279	S	Phosphorylation
72	283	S	Phosphorylation
73	2866	S	Phosphorylation
74	2866	S	Phosphorylation
75	2870	S	Phosphorylation
76	2871	S	Phosphorylation
77	2938	S	Phosphorylation
78	2940	T	Phosphorylation
79	2940	T	Phosphorylation
80	2953	S	Phosphorylation
81	2955	S	Phosphorylation
82	2955	S	Phosphorylation
83	3028	T	Phosphorylation
84	3036	S	Phosphorylation
85	3036	S	Phosphorylation
86	3038	T	Phosphorylation
87	3050	S	Phosphorylation
88	3053	S	Phosphorylation
89	3057	S	Phosphorylation
90	3067	T	Phosphorylation
91	3213	T	Phosphorylation
92	3216	S	Phosphorylation
93	337	T	Phosphorylation
94	337	T	Phosphorylation
95	3372	T	Phosphorylation
96	3372	T	Phosphorylation
97	3508	S	Phosphorylation
98	3510	T	Phosphorylation
99	3511	S	Phosphorylation
100	3511	S	Phosphorylation
101	3515	S	Phosphorylation
102	3515	S	Phosphorylation
103	3517	S	Phosphorylation
104	3517	S	Phosphorylation
105	3518	S	Phosphorylation
106	3518	S	Phosphorylation
107	3525	S	Phosphorylation
108	3525	S	Phosphorylation
109	3527	S	Phosphorylation
110	3644	S	Phosphorylation
111	3707	K	Ubiquitylation
112	3749	K	Acetylation
113	3784	K	Ubiquitylation
114	418	S	Phosphorylation
115	424	T	Phosphorylation
116	504	S	Phosphorylation
117	506	T	Phosphorylation
118	506	T	Phosphorylation
119	516	S	Phosphorylation
120	518	S	Phosphorylation
121	518	S	Phosphorylation
122	636	K	Acetylation
123	636	K	Acetylation
124	645	K	Ubiquitylation
125	680	S	Phosphorylation
126	680	S	Phosphorylation
127	684	S	Phosphorylation
128	742	S	Phosphorylation
129	828	S	Phosphorylation
130	829	S	Phosphorylation
131	831	S	Phosphorylation
132	831	S	Phosphorylation
133	833	T	Phosphorylation
134	840	T	Phosphorylation
135	840	T	Phosphorylation
136	897	S	Phosphorylation
137	901	S	Phosphorylation
138	926	S	Phosphorylation
139	926	S	Phosphorylation
140	972	T	Phosphorylation
141	982	S	Phosphorylation

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
KMT2A	KMT2A	KMT2A	ENSP00000374157	Q03164
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q03164	KMT2A	ENSP00000374157	KMT2A	Q03164
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
KMT2A	ENSP00000374157	159555	Q03164	PA241

dbEM

Protein: KMT2A

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)