dbEM

Protein: KMT2B

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Mutation Data (+)

# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction

*NP: Not Predicted
Copy number variation and expression profile (+)

Expression and CNV data is not present for KMT2B!!
Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

Gene essentiality data is not present in COLT database!!
Tertiary structure (+)

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Modelled Structure Structures available in PDB

3UVM, 4ERZ, 4PZI,

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PB004963	Pfam-B_4963	323	394	1.6e-06
PB002901	Pfam-B_2901	358	466	0.00082
PB011202	Pfam-B_11202	859	885	1.7e-08
PF02008	zf-CXXC	960	1005	5.1e-12
PB003525	Pfam-B_3525	1167	1219	4.5e-09
PB003418	Pfam-B_3418	1170	1245	4.5e-11
PB004447	Pfam-B_4447	1243	1333	1.5e-28
PF00628	PHD	1251	1302	3.6e-08
PF00628	PHD	1337	1394	2.2e-08
PB006332	Pfam-B_6332	1398	1479	9.8e-29
PF13771	zf-HC5HC2H	1608	1686	2e-15
PF05964	FYRN	1732	1782	2.1e-17
PF05965	FYRC	2412	2494	2.1e-23
PF00856	SET	2586	2690	1.6e-24

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0041233	2562	2715	7.59e-47
0050474	1237	1308	1.20e-10
0050474	1334	1405	3.77e-09
0037717	1200	1251	3.99e-04

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Mutants are not present in CCLE!!

4. Mutants are not present in COSMIC!!

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

  Sequence Profiles (+)

HMM
  With Uniprot database     With Mutants      With 1000 Genome Variants
PSSM
  With Uniprot database     With Mutants      With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type
1	1032	S	Phosphorylation
2	1032	S	Phosphorylation
3	1035	S	Phosphorylation
4	1035	S	Phosphorylation
5	1039	S	Phosphorylation
6	1092	S	Phosphorylation
7	1095	S	Phosphorylation
8	1164	S	Phosphorylation
9	1164	S	Phosphorylation
10	158	T	Phosphorylation
11	159	T	Phosphorylation
12	159	T	Phosphorylation
13	172	T	Phosphorylation
14	172	T	Phosphorylation
15	176	T	Phosphorylation
16	176	T	Phosphorylation
17	1930	S	Phosphorylation
18	1930	S	Phosphorylation
19	1935	T	Phosphorylation
20	1935	T	Phosphorylation
21	1936	S	Phosphorylation
22	2	A	Acetylation
23	2068	T	Phosphorylation
24	2070	S	Phosphorylation
25	2083	T	Phosphorylation
26	2083	T	Phosphorylation
27	2196	K	Ubiquitylation
28	2270	S	Phosphorylation
29	2296	K	Acetylation
30	2296	K	Acetylation
31	2604	Y	Phosphorylation
32	2605	S	Phosphorylation
33	351	S	Phosphorylation
34	351	S	Phosphorylation
35	797	K	Ubiquitylation
36	821	S	Phosphorylation
37	821	S	Phosphorylation
38	844	S	Phosphorylation
39	844	S	Phosphorylation
40	848	S	Phosphorylation
41	857	S	Phosphorylation
42	861	S	Phosphorylation
43	861	S	Phosphorylation
44	926	K	Acetylation
45	926	K	Acetylation

Other Databases Link (+)

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
KMT2B	KMT2B	KMT2B	ENSP00000398837	Q9UMN6
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q9UMN6	KMT2B	ENSP00000398837	KMT2B	Q9UMN6
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
KMT2B	ENSP00000398837	606834	Q9UMN6	NA

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