dbEM

Protein: KMT2C

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Mutation Data (+)

# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction

*NP: Not Predicted
Copy number variation and expression profile (+)

Expression and CNV data is not present for KMT2C!!
Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

Gene essentiality data is not present in COLT database!!
Tertiary structure (+)

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Modelled Structure Structures available in PDB

2YSM, 2YUK, 3UVL, 4ERY,

Structure Domains (+)

1. PFAM Domains:

Domain ID	Domain Name	Start Site	End Site	E-value
PF13771	zf-HC5HC2H	252	330	2.3e-11
PF00628	PHD	390	437	8.2e-09
PF00628	PHD	1009	1055	2.9e-09
PB006766	Pfam-B_6766	1022	1051	1.7e-07
PB014139	Pfam-B_14139	1492	1572	7.5e-16
PB019991	Pfam-B_19991	1874	2099	1.1e-38
PB016694	Pfam-B_16694	2533	2579	9.2e-23
PF13771	zf-HC5HC2H	4429	4507	5.8e-14
PF05964	FYRN	4550	4602	2.5e-20
PF05965	FYRC	4606	4693	1.6e-24
PF00856	SET	4782	4886	4.2e-24

2. Superfamily Domains:

Domain ID	Start Site	End Site	E-value
0041233	4753	4911	1.70e-48
0050474	381	443	1.31e-13
0050474	1000	1061	2.88e-13
0050474	950	1008	1.04e-10
0050470	1074	1141	7.31e-10
0037717	337	392	5.32e-09
0050474	457	520	2.88e-07
0035973	1655	1702	1.44e-05

Sequence Alignment (+)

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1. Sequence alignment with 1000 genome variations:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

2. Mutants are not present in CCLE!!

4. Mutants are not present in COSMIC!!

4. Sequence alignment with homologus proteins:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

  Sequence Profiles (+)

HMM
  With Uniprot database     With Mutants      With 1000 Genome Variants
PSSM
  With Uniprot database     With Mutants      With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type
1	111	S	Phosphorylation
2	113	S	Phosphorylation
3	116	S	Phosphorylation
4	119	S	Phosphorylation
5	1219	T	Phosphorylation
6	1248	S	Phosphorylation
7	1250	S	Phosphorylation
8	1251	S	Phosphorylation
9	1301	S	Phosphorylation
10	1493	S	Phosphorylation
11	1508	K	Acetylation
12	1508	K	Acetylation
13	1772	K	Acetylation
14	1772	K	Acetylation
15	1991	S	Phosphorylation
16	2003	T	Phosphorylation
17	2009	K	Acetylation
18	2009	K	Acetylation
19	2695	S	Phosphorylation
20	2795	K	Acetylation
21	2802	K	Acetylation
22	2802	K	Acetylation
23	2809	K	Acetylation
24	2809	K	Acetylation
25	2814	K	Acetylation
26	2824	T	Phosphorylation
27	2831	S	Phosphorylation
28	2832	K	Acetylation
29	2832	K	Acetylation
30	2930	S	Phosphorylation
31	2935	S	Phosphorylation
32	2937	S	Phosphorylation
33	2942	T	Phosphorylation
34	2946	S	Phosphorylation
35	2952	S	Phosphorylation
36	3124	S	Phosphorylation
37	3714	K	Acetylation
38	3714	K	Acetylation
39	3945	K	Acetylation
40	3945	K	Acetylation
41	4006	S	Phosphorylation
42	4018	Y	Phosphorylation
43	4018	Y	Phosphorylation
44	4022	S	Phosphorylation
45	4022	S	Phosphorylation
46	4034	S	Phosphorylation
47	4034	S	Phosphorylation
48	4050	S	Phosphorylation
49	4050	S	Phosphorylation
50	4227	S	Phosphorylation
51	4267	S	Phosphorylation
52	4300	S	Phosphorylation
53	4304	S	Phosphorylation
54	4388	T	Phosphorylation
55	46	S	Phosphorylation
56	625	S	Phosphorylation
57	631	S	Phosphorylation
58	758	K	Acetylation
59	758	K	Acetylation
60	827	K	Acetylation
61	827	K	Acetylation
62	89	S	Phosphorylation

Other Databases Link (+)

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
KMT2C	KMT2C	KMT2C	ENSP00000262189	Q8NEZ4
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q8NEZ4	KMT2C	ENSP00000262189	KMT2C	Q8NEZ4
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
KMT2C	ENSP00000262189	606833	Q8NEZ4	PA30847

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