dbEM

Protein: KMT2C

Mutation Data (+)

# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction

*NP: Not Predicted
Copy number variation and expression profile (+)

Expression and CNV data is not present for KMT2C!!
Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

Gene essentiality data is not present in COLT database!!
Tertiary structure (+)

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Modelled Structure Structures available in PDB
Structure Domains (+)

1. PFAM Domains:

2. Superfamily Domains:

Domain ID Start Site End Site E-value
381 443 1.31e-13
0050474 1000 1061 2.88e-13
0050474 950 1008 1.04e-10
0050470 1074 1141 7.31e-10
0037717 337 392 5.32e-09
0050474 457 520 2.88e-07
0035973 1655 1702 1.44e-05

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1. Sequence alignment with 1000 genome variations:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

2. Mutants are not present in CCLE!!

4. Mutants are not present in COSMIC!!

4. Sequence alignment with homologus proteins:

  Sequence Profiles (+)

HMM
  With Uniprot database     With Mutants      With 1000 Genome Variants
PSSM
  With Uniprot database     With Mutants      With 1000 Genome Variant
Post Translational Modifications (+)

Post translational modifications are not found!!
Other Databases Link (+)

Proteomics DB COSMIC Gene Atlas STRING PIR

KMT2C KMT2C KMT2C

QuickGO HGNC Ensembl Genome Browser TreeFam UniProt

KMT2C KMT2C

Expression Atlas Protein Atlas OMIM IntAct PharmGKB

KMT2C

Modelled Structure	Structures available in PDB