dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: MBD2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587222 LARGE INTESTINE c.586T>C p.Y196H COSMIC PASSENGER/OTHER Possibly Damaging 2 587268 LARGE INTESTINE c.592G>T p.G198* COSMIC NP NP 3 HCC37T LIVER c.1062A>G p.T354T COSMIC NP NP 4 HCT-15 LARGE INTESTINE c.549T>G p.S183R COSMIC PASSENGER/OTHER Benign 5 K-562 HAEMATOPOIETIC AND LYMPHOID TISSUE c.830A>C p.Q277P COSMIC PASSENGER/OTHER Probably Damaging 6 KM12 LARGE INTESTINE c.441_442insA p.R149fs*37 COSMIC NP NP 7 LUAD-D02185 LUNG c.392C>T p.S131L COSMIC PASSENGER/OTHER Probably Damaging 8 LUAD-NYU1219 LUNG c.592G>T p.G198* COSMIC NP NP 9 SA231 BREAST c.624C>G p.F208L COSMIC PASSENGER/OTHER Probably Damaging 10 TCGA-66-2782-01 LUNG c.410G>C p.G137A COSMIC PASSENGER/OTHER Possibly Damaging 11 TCGA-78-7155-01 LUNG c.1167A>G p.A389A COSMIC NP NP 12 TCGA-91-6847-01 LUNG c.703G>C p.G235R COSMIC PASSENGER/OTHER Probably Damaging 13 TCGA-AA-3811-01 LARGE INTESTINE c.1207A>G p.I403V COSMIC PASSENGER/OTHER Benign 14 TCGA-AA-3877-01 LARGE INTESTINE c.676C>T p.R226* COSMIC NP NP 15 TCGA-AG-3892-01 LARGE INTESTINE c.677G>A p.R226Q COSMIC PASSENGER/OTHER Possibly Damaging 16 TCGA-AP-A051-01 ENDOMETRIUM c.1190A>G p.D397G COSMIC PASSENGER/OTHER Possibly Damaging 17 TCGA-AP-A0LM-01 ENDOMETRIUM c.865G>T p.G289* COSMIC NP NP 18 TCGA-AX-A05Z-01 ENDOMETRIUM c.1201A>C p.M401L COSMIC PASSENGER/OTHER Benign 19 TCGA-AX-A0J0-01 ENDOMETRIUM c.797A>C p.K266T COSMIC PASSENGER/OTHER Probably Damaging 20 TCGA-B5-A0JY-01 ENDOMETRIUM c.889G>T p.E297* COSMIC NP NP 21 TCGA-DK-A1A3-01 URINARY TRACT c.657G>A p.Q219Q COSMIC NP NP 22 WA41 PROSTATE c.1179G>A p.S393S COSMIC NP NP 23 pfg019T STOMACH c.665_668delAACA p.K222fs*17 COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 168 S Phosphorylation 2 181 S Phosphorylation 3 181 S Phosphorylation 4 183 S Phosphorylation 5 407 S Phosphorylation 6 407 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR MBD2 MBD2 MBD2 ENSP00000256429 Q9UBB5 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9UBB5 MBD2 ENSP00000256429 MBD2 Q9UBB5 Expression Atlas Protein Atlas OMIM IntAct PharmGKB MBD2 ENSP00000256429 603547 Q9UBB5 PA30660
