dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: MBD3 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 43T SKIN c.677G>A p.R226K COSMIC PASSENGER/OTHER Possibly Damaging 2 587278 LARGE INTESTINE c.193C>T p.R65C COSMIC PASSENGER/OTHER Probably Damaging 3 ESO-859 OESOPHAGUS c.302T>C p.V101A COSMIC PASSENGER/OTHER Possibly Damaging 4 HN_62338 UPPER AERODIGESTIVE TRACT c.372G>C p.K124N COSMIC PASSENGER/OTHER Probably Damaging 5 LC_C13 LUNG c.192C>A p.F64L COSMIC PASSENGER/OTHER Probably Damaging 6 LC_C32 LUNG c.129C>A p.F43L COSMIC PASSENGER/OTHER Benign 7 MBRep_T43 CENTRAL NERVOUS SYSTEM c.688G>T p.E230* COSMIC NP NP 8 TCGA-13-1484-01 OVARY c.736G>C p.D246H COSMIC PASSENGER/OTHER Probably Damaging 9 TCGA-49-4487-01 LUNG c.751G>T p.V251L COSMIC PASSENGER/OTHER Benign 10 TCGA-55-6968-01 LUNG c.729G>A p.L243L COSMIC NP NP 11 TCGA-55-6968-01 LUNG c.802G>A p.E268K COSMIC PASSENGER/OTHER Benign 12 TCGA-AA-A01G-01 LARGE INTESTINE c.595G>A p.A199T COSMIC PASSENGER/OTHER Possibly Damaging 13 TCGA-AO-A1KT-01 BREAST c.198G>A p.T66T COSMIC NP NP 14 TCGA-AX-A0J0-01 ENDOMETRIUM c.345T>G p.I115M COSMIC PASSENGER/OTHER Possibly Damaging 15 TCGA-AZ-6598-01 LARGE INTESTINE c.36G>A p.P12P COSMIC NP NP 16 TCGA-DK-A3IK-01 URINARY TRACT c.384G>A p.Q128Q COSMIC NP NP 17 TCGA-DY-A1DF-01 LARGE INTESTINE c.19G>A p.E7K COSMIC PASSENGER/OTHER Benign 18 TCGA-E2-A15C-01 BREAST c.260A>G p.N87S COSMIC PASSENGER/OTHER Benign 19 TCGA-F4-6570-01 LARGE INTESTINE c.738C>T p.D246D COSMIC NP NP 20 TCGA-G4-6628-01 LARGE INTESTINE c.261C>T p.N87N COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 109 K Acetylation 2 109 K Acetylation 3 141 K Ubiquitylation 4 141 K Acetylation 5 141 K Acetylation 6 144 S Phosphorylation 7 144 S Phosphorylation 8 24 S Phosphorylation (AURKA) 9 24 S Phosphorylation 10 35 Y Phosphorylation 11 36 Y Phosphorylation 12 37 S Phosphorylation 13 4 K Acetylation 14 56 S Phosphorylation 15 56 S Phosphorylation 16 77 S Phosphorylation 17 85 S Phosphorylation 18 86 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR MBD3 MBD3 MBD3 ENSP00000156825 O95983 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O95983 MBD3 ENSP00000156825 MBD3 O95983 Expression Atlas Protein Atlas OMIM IntAct PharmGKB MBD3 ENSP00000156825 603573 O95983 PA30661
