dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: MBD4 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 585210 LUNG c.976G>T p.E326* COSMIC NP NP 2 587342 LARGE INTESTINE c.752G>T p.R251M COSMIC PASSENGER/OTHER Possibly Damaging 3 ESO-0459 OESOPHAGUS c.1298A>G p.K433R COSMIC PASSENGER/OTHER Probably Damaging 4 ESO-075 OESOPHAGUS c.1483G>C p.D495H COSMIC PASSENGER/OTHER Possibly Damaging 5 ESO-859 OESOPHAGUS c.326A>G p.Y109C COSMIC PASSENGER/OTHER Probably Damaging 6 ESO-866 OESOPHAGUS c.1056T>C p.F352F COSMIC NP NP 7 H2009 LUNG c.1418T>G p.M473R COSMIC PASSENGER/OTHER Benign 8 ID46 HAEMATOPOIETIC AND LYMPHOID TISSUE c.896C>A p.T299N COSMIC PASSENGER/OTHER Benign 9 LC_C27 LUNG c.217C>T p.Q73* COSMIC NP NP 10 LUAD-FH5PJ LUNG c.501A>G p.L167L COSMIC NP NP 11 LUAD-NYU201 LUNG c.546C>A p.S182R COSMIC PASSENGER/OTHER Benign 12 ME024T NS c.1387A>G p.T463A COSMIC PASSENGER/OTHER Probably Damaging 13 NCI-H2009 LUNG c.1418T>G p.M473R COSMIC PASSENGER/OTHER Benign 14 PD4934a BREAST c.240A>G p.T80T COSMIC NP NP 15 TCGA-13-1510-01 OVARY c.1019A>G p.K340R COSMIC PASSENGER/OTHER Benign 16 TCGA-24-1604-01 OVARY c.1475G>C p.R492T COSMIC PASSENGER/OTHER Benign 17 TCGA-29-2429-01 OVARY c.906G>C p.V302V COSMIC NP NP 18 TCGA-55-1595-01 LUNG c.752G>T p.R251M COSMIC PASSENGER/OTHER Possibly Damaging 19 TCGA-56-5897-01 LUNG c.1480G>A p.A494T COSMIC PASSENGER/OTHER Probably Damaging 20 TCGA-60-2698-01 LUNG c.1501G>C p.E501Q COSMIC PASSENGER/OTHER Possibly Damaging 21 TCGA-64-5781-01 LUNG c.1516C>G p.L506V COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-A3-3374-01 KIDNEY c.1448A>T p.E483V COSMIC PASSENGER/OTHER Benign 23 TCGA-A3-3374-01 KIDNEY c.729T>A p.I243I COSMIC NP NP 24 TCGA-A5-A0GN-01 ENDOMETRIUM c.1532_1534delTTC p.L511delL COSMIC NP NP 25 TCGA-A5-A0VQ-01 ENDOMETRIUM c.1325G>A p.R442Q COSMIC PASSENGER/OTHER Possibly Damaging 26 TCGA-A6-6137-01 LARGE INTESTINE c.139G>A p.G47R COSMIC PASSENGER/OTHER Benign 27 TCGA-AA-3971-01 LARGE INTESTINE c.1666G>A p.V556M COSMIC PASSENGER/OTHER Probably Damaging 28 TCGA-AA-3977-01 LARGE INTESTINE c.1694A>C p.K565T COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-AA-3984-01 LARGE INTESTINE c.1519G>A p.G507S COSMIC CANCER Probably Damaging 30 TCGA-AA-A010-01 LARGE INTESTINE c.393T>C p.N131N COSMIC NP NP 31 TCGA-AP-A051-01 ENDOMETRIUM c.1319C>A p.P440H COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-AP-A056-01 ENDOMETRIUM c.797C>A p.S266Y COSMIC PASSENGER/OTHER Possibly Damaging 33 TCGA-AP-A0LM-01 ENDOMETRIUM c.247C>T p.R83C COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-AX-A0J0-01 ENDOMETRIUM c.1074C>T p.I358I COSMIC NP NP 35 TCGA-AX-A0J0-01 ENDOMETRIUM c.404C>A p.S135Y COSMIC PASSENGER/OTHER Possibly Damaging 36 TCGA-AX-A0J0-01 ENDOMETRIUM c.61A>G p.T21A COSMIC PASSENGER/OTHER Benign 37 TCGA-BP-4977-01 KIDNEY c.1264T>C p.Y422H COSMIC PASSENGER/OTHER Possibly Damaging 38 TCGA-BS-A0UF-01 ENDOMETRIUM c.142G>T p.E48* COSMIC NP NP 39 TCGA-C8-A133-01 BREAST c.1217G>A p.R406Q COSMIC PASSENGER/OTHER Possibly Damaging 40 TCGA-CA-6718-01 LARGE INTESTINE c.1534C>T p.R512W COSMIC PASSENGER/OTHER Probably Damaging 41 TCGA-CJ-5681-01 KIDNEY c.1709T>C p.L570P COSMIC PASSENGER/OTHER Probably Damaging 42 TCGA-CL-5917-01 LARGE INTESTINE c.1211T>C p.I404T COSMIC PASSENGER/OTHER Possibly Damaging 43 TCGA-CM-6161-01 LARGE INTESTINE c.1419G>A p.M473I COSMIC PASSENGER/OTHER Benign 44 TCGA-CZ-5459-01 KIDNEY c.1377T>C p.L459L COSMIC NP NP 45 TCGA-D1-A103-01 ENDOMETRIUM c.1132C>T p.R378C COSMIC PASSENGER/OTHER Benign 46 TCGA-D1-A103-01 ENDOMETRIUM c.368C>A p.S123* COSMIC NP NP 47 TCGA-D1-A17F-01 ENDOMETRIUM c.1048G>A p.D350N COSMIC PASSENGER/OTHER Benign 48 TCGA-EW-A1IZ-01 BREAST c.58G>A p.V20I COSMIC PASSENGER/OTHER Benign 49 TCGA-G4-6299-01 LARGE INTESTINE c.392A>G p.N131S COSMIC PASSENGER/OTHER Benign 50 WA32 PROSTATE c.745G>A p.G249R COSMIC PASSENGER/OTHER Benign 51 YUBER SKIN c.1554G>T p.K518N COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 165 S Phosphorylation 2 262 S Phosphorylation 3 318 S Phosphorylation 4 428 S Phosphorylation 5 484 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR MBD4 MBD4 MBD4 ENSP00000249910 O95243 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O95243 MBD4 ENSP00000249910 MBD4 O95243 Expression Atlas Protein Atlas OMIM IntAct PharmGKB MBD4 ENSP00000249910 603574 O95243 PA30663
