dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: MCRS1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 17D HAEMATOPOIETIC AND LYMPHOID TISSUE c.928C>T p.R310* COSMIC NP NP 2 587278 LARGE INTESTINE c.1316G>A p.R439H COSMIC CANCER Probably Damaging 3 KM12 LARGE INTESTINE c.1087C>T p.R363W COSMIC NP NP 4 KM12 LARGE INTESTINE c.1264C>T p.R422* COSMIC NP NP 5 KM12 LARGE INTESTINE c.1291C>T p.P431S COSMIC NP Probably Damaging 6 LUAD-B00915 LUNG c.217G>T p.E73* COSMIC NP NP 7 LUAD-S01315 LUNG c.67G>C p.D23H COSMIC NP NP 8 MDS-07 HAEMATOPOIETIC AND LYMPHOID TISSUE c.865_866insC p.D289fs*8 COSMIC NP NP 9 MDS-07 HAEMATOPOIETIC AND LYMPHOID TISSUE c.865_866insG p.D289fs*8 COSMIC NP NP 10 Mx22 LARGE INTESTINE c.1360G>A p.V454I COSMIC NP NP 11 SA214 BREAST c.1267C>T p.R423W COSMIC NP NP 12 TCGA-22-1016-01 LUNG c.546G>T p.R182R COSMIC NP NP 13 TCGA-38-4625-01 LUNG c.112G>C p.E38Q COSMIC NP NP 14 TCGA-38-4625-01 LUNG c.1402G>C p.E468Q COSMIC NP NP 15 TCGA-44-6776-01 LUNG c.895G>C p.D299H COSMIC NP NP 16 TCGA-64-5781-01 LUNG c.186C>A p.S62S COSMIC NP NP 17 TCGA-66-2787-01 LUNG c.1406C>A p.A469D COSMIC NP NP 18 TCGA-A2-A0CT-01 BREAST c.928C>G p.R310G COSMIC NP Probably Damaging 19 TCGA-AA-3663-01 LARGE INTESTINE c.1091G>A p.G364D COSMIC NP NP 20 TCGA-AA-A010-01 LARGE INTESTINE c.1245C>A p.F415L COSMIC NP NP 21 TCGA-AD-5900-01 LARGE INTESTINE c.287G>A p.R96H COSMIC NP NP 22 TCGA-AG-3581-01 LARGE INTESTINE c.8G>A p.R3H COSMIC NP NP 23 TCGA-AP-A051-01 ENDOMETRIUM c.391C>T p.R131C COSMIC NP NP 24 TCGA-AP-A056-01 ENDOMETRIUM c.210C>T p.F70F COSMIC NP NP 25 TCGA-AP-A0LP-01 ENDOMETRIUM c.1237G>A p.G413S COSMIC NP NP 26 TCGA-B0-5098-01 KIDNEY c.1121G>A p.R374H COSMIC NP NP 27 TCGA-B5-A11E-01 ENDOMETRIUM c.1034G>T p.S345I COSMIC NP NP 28 TCGA-B5-A11E-01 ENDOMETRIUM c.1389C>T p.A463A COSMIC NP NP 29 TCGA-BG-A0VZ-01 ENDOMETRIUM c.1267C>T p.R423W COSMIC NP NP 30 TCGA-BH-A0HX-01 BREAST c.842C>G p.T281R COSMIC NP NP 31 TCGA-D1-A17R-01 ENDOMETRIUM c.136C>T p.R46* COSMIC NP NP 32 TCGA-D5-6540-01 LARGE INTESTINE c.340C>A p.P114T COSMIC NP NP 33 TCGA-D8-A147-01 BREAST c.676G>A p.E226K COSMIC NP NP 34 TCGA-G4-6588-01 LARGE INTESTINE c.1103G>A p.R368Q COSMIC NP NP 35 YULAN SKIN c.988C>T p.R330W COSMIC NP NP 36 YUWALI SKIN c.539C>T p.T180I COSMIC NP NP 37 pfg008T STOMACH c.197A>G p.K66R COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
