dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: MGEA5 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 118135 SALIVARY GLAND c.940C>G p.P314A COSMIC PASSENGER/OTHER Probably Damaging 2 585258 LUNG c.388G>T p.E130* COSMIC NP NP 3 587222 LARGE INTESTINE c.2740C>T p.R914W COSMIC PASSENGER/OTHER Probably Damaging 4 587376 LARGE INTESTINE c.2200G>T p.E734* COSMIC NP NP 5 5T SKIN c.1718C>T p.P573L COSMIC PASSENGER/OTHER Benign 6 HCC6T LIVER c.1990C>T p.R664C COSMIC PASSENGER/OTHER Probably Damaging 7 HX10T LIVER c.2090G>A p.G697E COSMIC PASSENGER/OTHER Benign 8 LC_C9 LUNG c.2273G>T p.G758V COSMIC PASSENGER/OTHER Probably Damaging 9 LUAD-RT-S01711 LUNG c.1345A>T p.T449S COSMIC PASSENGER/OTHER Benign 10 OLID02 CENTRAL NERVOUS SYSTEM c.2143T>C p.Y715H COSMIC PASSENGER/OTHER Probably Damaging 11 RK001_C01 LIVER c.2584G>T p.A862S COSMIC PASSENGER/OTHER Benign 12 TCGA-05-4420-01 LUNG c.1121A>G p.Y374C COSMIC PASSENGER/OTHER Probably Damaging 13 TCGA-13-0887-01 OVARY c.2692G>T p.E898* COSMIC NP NP 14 TCGA-22-5473-01 LUNG c.2286C>T p.L762L COSMIC NP NP 15 TCGA-25-1313-01 OVARY c.2453A>T p.E818V COSMIC PASSENGER/OTHER Probably Damaging 16 TCGA-35-5375-01 LUNG c.577C>T p.H193Y COSMIC PASSENGER/OTHER Possibly Damaging 17 TCGA-49-4487-01 LUNG c.2476G>A p.E826K COSMIC PASSENGER/OTHER Possibly Damaging 18 TCGA-55-8089-01 LUNG c.264G>T p.W88C COSMIC PASSENGER/OTHER Probably Damaging 19 TCGA-56-6545-01 LUNG c.429C>G p.I143M COSMIC PASSENGER/OTHER Probably Damaging 20 TCGA-61-1914-01 OVARY c.917G>A p.R306Q COSMIC PASSENGER/OTHER Possibly Damaging 21 TCGA-A6-5661-01 LARGE INTESTINE c.406G>A p.A136T COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-AA-3684-01 LARGE INTESTINE c.2537A>G p.D846G COSMIC PASSENGER/OTHER Benign 23 TCGA-AA-3695-01 LARGE INTESTINE c.909C>T p.L303L COSMIC NP NP 24 TCGA-AA-3715-01 LARGE INTESTINE c.1564A>G p.S522G COSMIC PASSENGER/OTHER Benign 25 TCGA-AP-A051-01 ENDOMETRIUM c.1391C>A p.P464H COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-AP-A056-01 ENDOMETRIUM c.1756C>T p.R586* COSMIC NP NP 27 TCGA-AP-A059-01 ENDOMETRIUM c.2620C>T p.R874W COSMIC PASSENGER/OTHER Probably Damaging 28 TCGA-AP-A0LM-01 ENDOMETRIUM c.2522C>A p.S841Y COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-AX-A0J1-01 ENDOMETRIUM c.2325C>T p.G775G COSMIC NP NP 30 TCGA-AZ-4315-01 LARGE INTESTINE c.1470G>A p.A490A COSMIC NP NP 31 TCGA-AZ-4315-01 LARGE INTESTINE c.1955C>T p.S652F COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-AZ-6600-01 LARGE INTESTINE c.2692G>T p.E898* COSMIC NP NP 33 TCGA-B5-A0JY-01 ENDOMETRIUM c.2224T>G p.L742V COSMIC PASSENGER/OTHER Benign 34 TCGA-B5-A11N-01 ENDOMETRIUM c.1756C>T p.R586* COSMIC NP NP 35 TCGA-B5-A11Q-01 ENDOMETRIUM c.4G>T p.V2L COSMIC PASSENGER/OTHER Possibly Damaging 36 TCGA-BP-4967-01 KIDNEY c.1898A>G p.N633S COSMIC PASSENGER/OTHER Probably Damaging 37 TCGA-BP-5189-01 KIDNEY c.2023G>T p.D675Y COSMIC PASSENGER/OTHER Probably Damaging 38 TCGA-CA-6717-01 LARGE INTESTINE c.1756C>T p.R586* COSMIC NP NP 39 TCGA-CM-6165-01 LARGE INTESTINE c.2453A>G p.E818G COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-CU-A0YO-01 URINARY TRACT c.2504T>C p.F835S COSMIC PASSENGER/OTHER Possibly Damaging 41 TCGA-D1-A167-01 ENDOMETRIUM c.1321G>T p.G441* COSMIC NP NP 42 TCGA-DI-A0WH-01 ENDOMETRIUM c.2553A>G p.V851V COSMIC NP NP 43 TCGA-DI-A0WH-01 ENDOMETRIUM c.986C>T p.A329V COSMIC PASSENGER/OTHER Probably Damaging 44 TCGA-DK-A3IT-01 URINARY TRACT c.628G>A p.E210K COSMIC PASSENGER/OTHER Benign 45 TCGA-DM-A1DB-01 LARGE INTESTINE c.2453A>G p.E818G COSMIC PASSENGER/OTHER Probably Damaging 46 TCGA-E2-A1LB-01 BREAST c.836A>T p.D279V COSMIC PASSENGER/OTHER Probably Damaging 47 TCGA-G2-A2ES-01 URINARY TRACT c.1504G>A p.D502N COSMIC PASSENGER/OTHER Benign 48 TCGA-GD-A3OS-01 URINARY TRACT c.1075T>A p.L359I COSMIC PASSENGER/OTHER Probably Damaging 49 YUFOLD SKIN c.581C>T p.A194V COSMIC PASSENGER/OTHER Probably Damaging 50 YUZINO SKIN c.2387C>T p.S796F COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 240 K Ubiquitylation 2 257 K Ubiquitylation 3 268 S Phosphorylation 4 297 K Ubiquitylation 5 364 S Phosphorylation 6 364 S Phosphorylation 7 370 T Phosphorylation 8 405 S O-linked Glycosylation 9 709 T Phosphorylation 10 723 K Ubiquitylation 11 859 S Phosphorylation 12 867 S Phosphorylation 13 87 K Ubiquitylation 14 873 S Phosphorylation 15 896 C S-nitrosylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR MGEA5 MGEA5 MGEA5 ENSP00000350445 O60502 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O60502 MGEA5 ENSP00000350445 MGEA5 O60502 Expression Atlas Protein Atlas OMIM IntAct PharmGKB MGEA5 ENSP00000350445 604039 O60502 PA30787
