dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: MTA1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 1946219 LUNG c.1259G>C p.C420S COSMIC CANCER Probably Damaging 2 587278 LARGE INTESTINE c.1607C>T p.A536V COSMIC PASSENGER/OTHER Benign 3 587294 LARGE INTESTINE c.1898G>A p.R633H COSMIC PASSENGER/OTHER Probably Damaging 4 587316 LARGE INTESTINE c.212C>T p.A71V COSMIC PASSENGER/OTHER Benign 5 587332 LARGE INTESTINE c.403G>A p.E135K COSMIC PASSENGER/OTHER Probably Damaging 6 587338 LARGE INTESTINE c.2143G>T p.D715Y COSMIC PASSENGER/OTHER Probably Damaging 7 BN24T LIVER c.427C>T p.R143W COSMIC PASSENGER/OTHER Probably Damaging 8 Br27P CENTRAL NERVOUS SYSTEM c.1105G>A p.V369I COSMIC PASSENGER/OTHER Benign 9 ESO-0061 OESOPHAGUS c.1944G>A p.M648I COSMIC PASSENGER/OTHER Benign 10 GC8_T STOMACH c.1114G>A p.V372I COSMIC PASSENGER/OTHER Benign 11 H650 LUNG c.1123G>T p.G375C COSMIC PASSENGER/OTHER Possibly Damaging 12 HCC1599 BREAST c.1427C>T p.T476M COSMIC PASSENGER/OTHER Probably Damaging 13 HCC4T LIVER c.133T>C p.F45L COSMIC PASSENGER/OTHER Benign 14 HCC75T LIVER c.730G>C p.A244P COSMIC PASSENGER/OTHER Probably Damaging 15 HCT-15 LARGE INTESTINE c.34G>A p.V12I COSMIC PASSENGER/OTHER Probably Damaging 16 HX13T LIVER c.133T>C p.F45L COSMIC PASSENGER/OTHER Benign 17 LC_C18 LUNG c.1271G>T p.W424L COSMIC PASSENGER/OTHER Probably Damaging 18 LUAD-CHTN-3090346 LUNG c.1315G>C p.E439Q COSMIC PASSENGER/OTHER Possibly Damaging 19 LUAD-CHTN-3090415 LUNG c.225delG p.D76fs*8 COSMIC NP NP 20 LUAD-CHTN-3090416 LUNG c.772C>T p.L258F COSMIC PASSENGER/OTHER Probably Damaging 21 LUAD-RT-S01702 LUNG c.112G>A p.V38M COSMIC PASSENGER/OTHER Probably Damaging 22 LUAD-S01405 LUNG c.1956C>T p.D652D COSMIC NP NP 23 MD-284 CENTRAL NERVOUS SYSTEM c.1850C>A p.P617Q COSMIC PASSENGER/OTHER Possibly Damaging 24 RPMI-8226 HAEMATOPOIETIC AND LYMPHOID TISSUE c.909T>A p.Y303* COSMIC NP NP 25 S00936 LUNG c.603G>A p.A201A COSMIC NP NP 26 TCGA-23-2649-01 OVARY c.1193C>T p.T398I COSMIC PASSENGER/OTHER Benign 27 TCGA-29-2432-01 OVARY c.1069C>G p.P357A COSMIC PASSENGER/OTHER Probably Damaging 28 TCGA-35-5375-01 LUNG c.355G>A p.A119T COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-37-3789-01 LUNG c.883C>A p.L295I COSMIC PASSENGER/OTHER Possibly Damaging 30 TCGA-55-7910-01 LUNG c.1471C>T p.R491C COSMIC PASSENGER/OTHER Probably Damaging 31 TCGA-66-2785-01 LUNG c.36C>G p.V12V COSMIC NP NP 32 TCGA-86-6851-01 LUNG c.117G>T p.E39D COSMIC PASSENGER/OTHER Probably Damaging 33 TCGA-86-6851-01 LUNG c.653G>T p.R218L COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-A5-A0VP-01 ENDOMETRIUM c.1804C>T p.P602S COSMIC PASSENGER/OTHER Probably Damaging 35 TCGA-AA-3510-01 LARGE INTESTINE c.888C>T p.F296F COSMIC NP NP 36 TCGA-AA-A01Q-01 LARGE INTESTINE c.113_114insG p.E39fs*32 COSMIC NP NP 37 TCGA-AP-A059-01 ENDOMETRIUM c.978C>A p.Y326* COSMIC NP NP 38 TCGA-AP-A0LM-01 ENDOMETRIUM c.1252G>A p.A418T COSMIC PASSENGER/OTHER Benign 39 TCGA-AZ-4315-01 LARGE INTESTINE c.723C>T p.S241S COSMIC NP NP 40 TCGA-AZ-6598-01 LARGE INTESTINE c.1828G>A p.G610R COSMIC PASSENGER/OTHER Possibly Damaging 41 TCGA-B0-4823-01 KIDNEY c.1182G>C p.E394D COSMIC PASSENGER/OTHER Probably Damaging 42 TCGA-B5-A11E-01 ENDOMETRIUM c.602C>T p.A201V COSMIC PASSENGER/OTHER Possibly Damaging 43 TCGA-BG-A0W1-01 ENDOMETRIUM c.33C>T p.Y11Y COSMIC NP NP 44 TCGA-BS-A0UF-01 ENDOMETRIUM c.1000G>A p.D334N COSMIC PASSENGER/OTHER Probably Damaging 45 TCGA-BS-A0UV-01 ENDOMETRIUM c.630C>T p.I210I COSMIC NP NP 46 TCGA-BT-A2LA-01 URINARY TRACT c.1691C>T p.T564M COSMIC PASSENGER/OTHER Possibly Damaging 47 TCGA-CA-6717-01 LARGE INTESTINE c.1243C>T p.R415C COSMIC PASSENGER/OTHER Probably Damaging 48 TCGA-CK-6746-01 LARGE INTESTINE c.1972T>C p.F658L COSMIC PASSENGER/OTHER Benign 49 TCGA-CM-4744-01 LARGE INTESTINE c.701G>A p.R234Q COSMIC PASSENGER/OTHER Probably Damaging 50 TCGA-D1-A17B-01 ENDOMETRIUM c.34G>A p.V12I COSMIC PASSENGER/OTHER Probably Damaging 51 TCGA-DI-A0WH-01 ENDOMETRIUM c.1353C>A p.H451Q COSMIC PASSENGER/OTHER Possibly Damaging 52 TCGA-DM-A1D4-01 LARGE INTESTINE c.1139C>T p.T380M COSMIC PASSENGER/OTHER Probably Damaging 53 TCGA-GV-A3JW-01 URINARY TRACT c.2034G>C p.K678N COSMIC PASSENGER/OTHER Possibly Damaging 54 YUKLAB SKIN c.1246C>T p.L416F COSMIC PASSENGER/OTHER Probably Damaging 55 YUKLAB SKIN c.1706C>T p.A569V COSMIC PASSENGER/OTHER Benign 56 YUSWI SKIN c.1243C>T p.R415C COSMIC PASSENGER/OTHER Probably Damaging 57 ccRCC-62 KIDNEY c.268C>A p.P90T COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 208 K Ubiquitylation 2 32 K Ubiquitylation 3 361 K Ubiquitylation 4 386 S Phosphorylation 5 386 S Phosphorylation 6 446 S Phosphorylation 7 449 S Phosphorylation 8 449 S Phosphorylation 9 467 T Phosphorylation 10 467 T Phosphorylation 11 509 K Sumoylation 12 520 S Phosphorylation 13 520 S Phosphorylation 14 522 S Phosphorylation 15 522 S Phosphorylation 16 527 K Ubiquitylation 17 561 S Phosphorylation 18 562 S Phosphorylation 19 564 T Phosphorylation 20 564 T Phosphorylation 21 576 S Phosphorylation 22 576 S Phosphorylation 23 578 T Phosphorylation 24 578 T Phosphorylation 25 626 K Acetylation 26 639 S Phosphorylation 27 659 Y Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR MTA1 MTA1 MTA1 ENSP00000333633 Q13330 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q13330 MTA1 ENSP00000333633 MTA1 Q13330 Expression Atlas Protein Atlas OMIM IntAct PharmGKB MTA1 ENSP00000333633 603526 Q13330 PA31218
