dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: MTA2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 12T SKIN c.299C>T p.T100I COSMIC PASSENGER/OTHER Probably Damaging 2 1874574 HAEMATOPOIETIC AND LYMPHOID TISSUE c.848A>G p.Y283C COSMIC PASSENGER/OTHER Probably Damaging 3 1946219 LUNG c.373G>T p.D125Y COSMIC PASSENGER/OTHER Probably Damaging 4 HCC119T LIVER c.1493G>A p.R498Q COSMIC PASSENGER/OTHER Probably Damaging 5 HCT-15 LARGE INTESTINE c.809C>T p.A270V COSMIC PASSENGER/OTHER Probably Damaging 6 HF-23896 LUNG c.373G>T p.D125Y COSMIC PASSENGER/OTHER Probably Damaging 7 HN_62237 UPPER AERODIGESTIVE TRACT c.435C>T p.G145G COSMIC NP NP 8 HN_62426 UPPER AERODIGESTIVE TRACT c.421C>T p.L141F COSMIC PASSENGER/OTHER Probably Damaging 9 HN_62426 UPPER AERODIGESTIVE TRACT c.534C>T p.V178V COSMIC NP NP 10 HN_62624 UPPER AERODIGESTIVE TRACT c.1409G>T p.R470M COSMIC PASSENGER/OTHER Possibly Damaging 11 KM12 LARGE INTESTINE c.311G>A p.G104E COSMIC PASSENGER/OTHER Probably Damaging 12 LAU165 SKIN c.1507G>A p.A503T COSMIC PASSENGER/OTHER Benign 13 LUAD-D02085 LUNG c.1375A>G p.T459A COSMIC PASSENGER/OTHER Possibly Damaging 14 LUAD-S01357 LUNG c.1936C>T p.R646W COSMIC PASSENGER/OTHER Probably Damaging 15 NB-1956 AUTONOMIC GANGLIA c.1678C>T p.R560W COSMIC PASSENGER/OTHER Probably Damaging 16 PR-00-1165 PROSTATE c.406G>A p.V136M COSMIC PASSENGER/OTHER Probably Damaging 17 SWE-1A PROSTATE c.1232A>G p.E411G COSMIC PASSENGER/OTHER Possibly Damaging 18 TCGA-18-3421-01 LUNG c.1746G>C p.G582G COSMIC NP NP 19 TCGA-20-1683-01 OVARY c.1151C>G p.P384R COSMIC CANCER Possibly Damaging 20 TCGA-25-2400-01 OVARY c.339G>T p.E113D COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-69-7978-01 LUNG c.82G>C p.E28Q COSMIC PASSENGER/OTHER Possibly Damaging 22 TCGA-97-7552-01 LUNG c.1382T>C p.L461P COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-A6-2672-01 LARGE INTESTINE c.1846C>A p.L616I COSMIC PASSENGER/OTHER Possibly Damaging 24 TCGA-AA-3492-01 LARGE INTESTINE c.325A>G p.T109A COSMIC PASSENGER/OTHER Probably Damaging 25 TCGA-AA-3713-01 LARGE INTESTINE c.307C>T p.R103W COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-AA-3977-01 LARGE INTESTINE c.122A>C p.K41T COSMIC PASSENGER/OTHER Probably Damaging 27 TCGA-AA-3977-01 LARGE INTESTINE c.1567G>T p.D523Y COSMIC PASSENGER/OTHER Possibly Damaging 28 TCGA-AA-A01D-01 LARGE INTESTINE c.1142G>A p.W381* COSMIC NP NP 29 TCGA-AB-2922-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.866A>G p.D289G COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-AP-A051-01 ENDOMETRIUM c.1463C>T p.A488V COSMIC PASSENGER/OTHER Possibly Damaging 31 TCGA-AP-A059-01 ENDOMETRIUM c.910G>T p.V304F COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-AY-4071-01 LARGE INTESTINE c.479G>A p.R160H COSMIC PASSENGER/OTHER Possibly Damaging 33 TCGA-AZ-6601-01 LARGE INTESTINE c.1850G>A p.R617Q COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-AZ-6601-01 LARGE INTESTINE c.307C>T p.R103W COSMIC PASSENGER/OTHER Probably Damaging 35 TCGA-B0-4712-01 KIDNEY c.1298G>A p.S433N COSMIC PASSENGER/OTHER Benign 36 TCGA-B5-A0JR-01 ENDOMETRIUM c.256C>A p.R86R COSMIC NP NP 37 TCGA-B5-A11E-01 ENDOMETRIUM c.1321G>A p.A441T COSMIC PASSENGER/OTHER Possibly Damaging 38 TCGA-B5-A11E-01 ENDOMETRIUM c.1994T>A p.V665D COSMIC PASSENGER/OTHER Probably Damaging 39 TCGA-B5-A11R-01 ENDOMETRIUM c.1782G>A p.Q594Q COSMIC NP NP 40 TCGA-B5-A11Y-01 ENDOMETRIUM c.1442G>A p.R481Q COSMIC PASSENGER/OTHER Possibly Damaging 41 TCGA-BH-A0HK-01 BREAST c.1068G>A p.M356I COSMIC PASSENGER/OTHER Benign 42 TCGA-BP-4995-01 KIDNEY c.222G>C p.G74G COSMIC NP NP 43 TCGA-CM-5344-01 LARGE INTESTINE c.337G>T p.E113* COSMIC NP NP 44 TCGA-G4-6299-01 LARGE INTESTINE c.139C>T p.R47W COSMIC PASSENGER/OTHER Probably Damaging 45 TCGA-G4-6588-01 LARGE INTESTINE c.1664_1665insG p.I556fs*8 COSMIC NP NP 46 TCGA-H4-A2HQ-01 URINARY TRACT c.790G>A p.E264K COSMIC PASSENGER/OTHER Probably Damaging 47 WA16 PROSTATE c.1843G>C p.A615P COSMIC PASSENGER/OTHER Possibly Damaging 48 YUZINO SKIN c.1453C>T p.P485S COSMIC PASSENGER/OTHER Benign 49 cSCCP7 SKIN c.656A>C p.H219P COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
