dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: MTA3 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587350 LARGE INTESTINE c.1468C>T p.R490W COSMIC PASSENGER/OTHER Probably Damaging 2 ESO-0176 OESOPHAGUS c.1113G>A p.Q371Q COSMIC NP NP 3 ESO-S41 OESOPHAGUS c.1441C>G p.Q481E COSMIC PASSENGER/OTHER Benign 4 GC1_T STOMACH c.108C>T p.G36G COSMIC NP NP 5 LC_S9 LUNG c.557delG p.S186fs*12 COSMIC NP NP 6 LUAD-E00934 LUNG c.1156C>T p.Q386* COSMIC NP NP 7 LUAD-S01315 LUNG c.496G>C p.E166Q COSMIC PASSENGER/OTHER Probably Damaging 8 NB-1243 AUTONOMIC GANGLIA c.1098C>G p.T366T COSMIC NP NP 9 TCGA-24-1423-01 OVARY c.922G>C p.E308Q COSMIC PASSENGER/OTHER Probably Damaging 10 TCGA-34-5927-01 LUNG c.417A>G p.S139S COSMIC NP NP 11 TCGA-50-6590-01 LUNG c.273C>G p.L91L COSMIC NP NP 12 TCGA-50-6593-01 LUNG c.552A>T p.P184P COSMIC NP NP 13 TCGA-51-4079-01 LUNG c.1374A>G p.P458P COSMIC NP NP 14 TCGA-55-8089-01 LUNG c.1052C>T p.S351F COSMIC PASSENGER/OTHER Probably Damaging 15 TCGA-55-8089-01 LUNG c.816A>T p.S272S COSMIC NP NP 16 TCGA-56-5897-01 LUNG c.1300G>C p.E434Q COSMIC PASSENGER/OTHER Possibly Damaging 17 TCGA-60-2726-01 LUNG c.752C>A p.A251D COSMIC PASSENGER/OTHER Probably Damaging 18 TCGA-66-2781-01 LUNG c.405C>G p.V135V COSMIC NP NP 19 TCGA-78-7158-01 LUNG c.735C>T p.S245S COSMIC NP NP 20 TCGA-A2-A0YH-01 BREAST c.477C>T p.D159D COSMIC NP NP 21 TCGA-A6-6653-01 LARGE INTESTINE c.709G>A p.A237T COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-AA-A010-01 LARGE INTESTINE c.143G>A p.R48Q COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-AG-A002-01 LARGE INTESTINE c.1039C>T p.P347S COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-AP-A059-01 ENDOMETRIUM c.1106A>T p.Q369L COSMIC PASSENGER/OTHER Benign 25 TCGA-AP-A059-01 ENDOMETRIUM c.235A>G p.T79A COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-AP-A0L9-01 ENDOMETRIUM c.409G>A p.D137N COSMIC PASSENGER/OTHER Probably Damaging 27 TCGA-AU-6004-01 LARGE INTESTINE c.579T>C p.I193I COSMIC NP NP 28 TCGA-B0-5712-01 KIDNEY c.994A>T p.S332C COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-B5-A121-01 ENDOMETRIUM c.1457C>G p.T486S COSMIC PASSENGER/OTHER Benign 30 TCGA-BH-A0AV-01 BREAST c.1130G>A p.R377K COSMIC CANCER Probably Damaging 31 TCGA-BH-A0DT-01 BREAST c.729A>C p.R243S COSMIC PASSENGER/OTHER Benign 32 TCGA-BS-A0UF-01 ENDOMETRIUM c.1215T>G p.I405M COSMIC CANCER Possibly Damaging 33 TCGA-CI-6624-01 LARGE INTESTINE c.918_919insA p.I307fs*2 COSMIC NP NP 34 TCGA-CK-6746-01 LARGE INTESTINE c.53C>A p.S18Y COSMIC PASSENGER/OTHER Probably Damaging 35 TCGA-CM-5864-01 LARGE INTESTINE c.1083T>C p.N361N COSMIC NP NP 36 TCGA-D1-A103-01 ENDOMETRIUM c.1275G>T p.E425D COSMIC PASSENGER/OTHER Benign 37 TCGA-G4-6628-01 LARGE INTESTINE c.851delA p.K285fs*19 COSMIC NP NP 38 ccRCC-70 KIDNEY c.55A>G p.S19G COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
-
Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
