dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: NCOA1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 22RV1 PROSTATE c.466G>A p.V156I CCLE PASSENGER/OTHER Possibly Damaging 2 A704 KIDNEY c.3226A>G p.I1076V CCLE PASSENGER/OTHER Benign 3 ACCS URINARY TRACT c.3364C>T p.R1122* CCLE NP NP 4 BICR18 UPPER AERODIGESTIVE TRACT c.4164A>G p.Q1388Q CCLE NP NP 5 BICR56 UPPER AERODIGESTIVE TRACT c.1664C>G p.S555C CCLE PASSENGER/OTHER Probably Damaging 6 CALU6 LUNG c.2713G>A p.E905K CCLE PASSENGER/OTHER Benign 7 CW2 LARGE INTESTINE c.3891T>A p.S1297R CCLE PASSENGER/OTHER Possibly Damaging 8 DMS454 LUNG c.1130C>A p.T377N CCLE PASSENGER/OTHER Benign 9 DMS53 LUNG c.2911G>C p.E971Q CCLE PASSENGER/OTHER Benign 10 ECC10 STOMACH c.3059C>A p.T1020K CCLE PASSENGER/OTHER Benign 11 EOL1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.4265C>T p.S1422L CCLE PASSENGER/OTHER Benign 12 FTC133 THYROID c.574A>G p.S192G CCLE PASSENGER/OTHER Benign 13 HCC1954 BREAST c.4117T>C p.S1373P CCLE PASSENGER/OTHER Probably Damaging 14 HCT116 LARGE INTESTINE c.2936C>T p.T979M CCLE PASSENGER/OTHER Possibly Damaging 15 HEC108 ENDOMETRIUM c.333C>A p.S111S CCLE NP NP 16 HEC108 ENDOMETRIUM c.3995A>G p.N1332S CCLE PASSENGER/OTHER Possibly Damaging 17 HEC251 ENDOMETRIUM c.2270A>C p.E757A CCLE PASSENGER/OTHER Probably Damaging 18 HEC59 ENDOMETRIUM c.2887_splice p.G963_splice CCLE NP NP 19 HEC6 ENDOMETRIUM c.2599_splice p.R867_splice CCLE NP NP 20 IGROV1 OVARY c.2887_splice p.G963_splice CCLE NP NP 21 JHUEM7 ENDOMETRIUM c.836C>T p.S279F CCLE PASSENGER/OTHER Probably Damaging 22 JHUEM7 ENDOMETRIUM c.871T>G p.L291V CCLE PASSENGER/OTHER Benign 23 KARPAS620 HAEMATOPOIETIC AND LYMPHOID TISSUE c.26C>T p.S9F CCLE PASSENGER/OTHER Benign 24 KASUMI1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2599_splice p.R867_splice CCLE NP NP 25 KASUMI2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.565C>T p.R189* CCLE NP NP 26 KMRC20 KIDNEY c.3086G>A p.R1029Q CCLE PASSENGER/OTHER Possibly Damaging 27 KP1NL PANCREAS c.76A>C p.T26P CCLE CANCER Benign 28 KP1N PANCREAS c.76A>C p.T26P CCLE CANCER Benign 29 KPNSI9S AUTONOMIC GANGLIA c.1442T>C p.I481T CCLE PASSENGER/OTHER Benign 30 KYSE520 OESOPHAGUS c.3914C>T p.T1305M CCLE PASSENGER/OTHER Possibly Damaging 31 LN229 CENTRAL NERVOUS SYSTEM c.3625A>G p.M1209V CCLE PASSENGER/OTHER Benign 32 MEWO SKIN c.3824C>T p.S1275F CCLE PASSENGER/OTHER Possibly Damaging 33 MKN7 STOMACH c.2003C>T p.S668F CCLE PASSENGER/OTHER Possibly Damaging 34 NCIH1581 LUNG c.218C>T p.T73I CCLE CANCER Probably Damaging 35 NCIH1944 LUNG c.2045C>T p.S682L CCLE PASSENGER/OTHER Probably Damaging 36 NCIH2066 LUNG c.1984G>T p.G662C CCLE PASSENGER/OTHER Possibly Damaging 37 NCIH2110 LUNG c.2659G>C p.D887H CCLE PASSENGER/OTHER Possibly Damaging 38 NCIH2342 LUNG c.1117C>T p.P373S CCLE PASSENGER/OTHER Benign 39 NCIH82 LUNG c.1761G>T p.E587D CCLE PASSENGER/OTHER Probably Damaging 40 NCIH838 LUNG c.2888G>T p.G963V CCLE PASSENGER/OTHER Probably Damaging 41 RKN SOFT TISSUE c.2753G>A p.C918Y CCLE PASSENGER/OTHER Probably Damaging 42 RKO LARGE INTESTINE c.2465A>G p.E822G CCLE PASSENGER/OTHER Possibly Damaging 43 RKO LARGE INTESTINE c.2509G>T p.D837Y CCLE PASSENGER/OTHER Possibly Damaging 44 SJRH30 SOFT TISSUE c.2323G>C p.V775L CCLE PASSENGER/OTHER Benign 45 SKOV3 OVARY c.3724G>A p.E1242K CCLE PASSENGER/OTHER Possibly Damaging 46 SKUT1 SOFT TISSUE c.3602G>A p.R1201H CCLE PASSENGER/OTHER Possibly Damaging 47 SNU175 LARGE INTESTINE c.2074C>T p.R692W CCLE PASSENGER/OTHER Probably Damaging 48 SNU175 LARGE INTESTINE c.3866C>T p.A1289V CCLE PASSENGER/OTHER Benign 49 SNU407 LARGE INTESTINE c.2570C>T p.A857V CCLE PASSENGER/OTHER Benign 50 SNU719 STOMACH c.291A>G p.S97S CCLE NP NP 51 SNUC2A LARGE INTESTINE c.3143C>T p.P1048L CCLE PASSENGER/OTHER Probably Damaging 52 SQ1 LUNG c.1475A>T p.Q492L CCLE PASSENGER/OTHER Benign 53 T98G CENTRAL NERVOUS SYSTEM c.3995A>G p.N1332S CCLE PASSENGER/OTHER Possibly Damaging 54 TE10 OESOPHAGUS c.1442T>C p.I481T CCLE PASSENGER/OTHER Benign 55 TE9 OESOPHAGUS c.4147_4148GG>TT p.G1383L CCLE PASSENGER/OTHER Probably Damaging 56 TGBC11TKB STOMACH c.157A>G p.N53D CCLE CANCER Probably Damaging 57 VMRCLCD LUNG c.1259G>A p.R420H CCLE PASSENGER/OTHER Benign 58 2334191 LUNG c.2088G>T p.E696D COSMIC PASSENGER/OTHER Possibly Damaging 59 2334191 LUNG c.4216G>T p.D1406Y COSMIC PASSENGER/OTHER Probably Damaging 60 2334199 LUNG c.611C>A p.P204Q COSMIC PASSENGER/OTHER Benign 61 587224 LARGE INTESTINE c.3045A>C p.K1015N COSMIC PASSENGER/OTHER Probably Damaging 62 587376 LARGE INTESTINE c.409T>G p.S137A COSMIC PASSENGER/OTHER Probably Damaging 63 587376 LARGE INTESTINE c.898T>G p.F300V COSMIC PASSENGER/OTHER Possibly Damaging 64 5T SKIN c.3217C>T p.R1073W COSMIC PASSENGER/OTHER Probably Damaging 65 ESO-164 OESOPHAGUS c.1538C>T p.S513L COSMIC PASSENGER/OTHER Benign 66 H1155 LUNG c.770C>T p.T257M COSMIC PASSENGER/OTHER Probably Damaging 67 HCC33T LIVER c.771G>A p.T257T COSMIC NP NP 68 LUAD-CHTN-3090416 LUNG c.2899G>A p.D967N COSMIC PASSENGER/OTHER Possibly Damaging 69 LUAD-RT-S01831 LUNG c.4184A>T p.D1395V COSMIC PASSENGER/OTHER Probably Damaging 70 NCI-H1770 LUNG c.2079_2080CT>TC p.(=) COSMIC NP NP 71 P05-3852 PROSTATE c.1355A>G p.N452S COSMIC PASSENGER/OTHER Benign 72 PD4937a BREAST c.907C>G p.Q303E COSMIC PASSENGER/OTHER Possibly Damaging 73 S01366 LUNG c.1758A>G p.K586K COSMIC NP NP 74 SA053 BREAST c.2743G>T p.E915* COSMIC NP NP 75 SA212 BREAST c.4069A>C p.N1357H COSMIC PASSENGER/OTHER Benign 76 SK01600_M CENTRAL NERVOUS SYSTEM c.2606C>A p.P869H COSMIC PASSENGER/OTHER Probably Damaging 77 SK01600_P CENTRAL NERVOUS SYSTEM c.2606C>A p.P869H COSMIC PASSENGER/OTHER Probably Damaging 78 TCGA-05-4405-01 LUNG c.2517G>A p.A839A COSMIC NP NP 79 TCGA-05-4420-01 LUNG c.909G>T p.Q303H COSMIC PASSENGER/OTHER Benign 80 TCGA-09-1674-01 OVARY c.4137_4138delAG p.E1380fs*15 COSMIC NP NP 81 TCGA-09-2051-01 OVARY c.391G>T p.G131W COSMIC PASSENGER/OTHER Probably Damaging 82 TCGA-13-0793-01 OVARY c.1067C>T p.P356L COSMIC PASSENGER/OTHER Probably Damaging 83 TCGA-18-3416-01 LUNG c.2298G>C p.L766L COSMIC NP NP 84 TCGA-18-5595-01 LUNG c.4044G>T p.M1348I COSMIC PASSENGER/OTHER Benign 85 TCGA-22-4599-01 LUNG c.1800C>G p.N600K COSMIC PASSENGER/OTHER Possibly Damaging 86 TCGA-22-4599-01 LUNG c.3751C>A p.P1251T COSMIC PASSENGER/OTHER Probably Damaging 87 TCGA-34-5236-01 LUNG c.2879T>C p.L960P COSMIC PASSENGER/OTHER Probably Damaging 88 TCGA-38-4632-01 LUNG c.1153C>A p.R385R COSMIC NP NP 89 TCGA-39-5027-01 LUNG c.2712A>T p.S904S COSMIC NP NP 90 TCGA-50-5930-01 LUNG c.337G>T p.G113* COSMIC NP NP 91 TCGA-50-5933-01 LUNG c.1170C>T p.V390V COSMIC NP NP 92 TCGA-50-5944-01 LUNG c.2227T>G p.S743A COSMIC PASSENGER/OTHER Benign 93 TCGA-55-6985-01 LUNG c.113A>G p.Q38R COSMIC CANCER Probably Damaging 94 TCGA-55-7727-01 LUNG c.1331C>G p.S444* COSMIC NP NP 95 TCGA-55-7907-01 LUNG c.2474C>T p.A825V COSMIC PASSENGER/OTHER Benign 96 TCGA-60-2725-01 LUNG c.4077C>G p.P1359P COSMIC NP NP 97 TCGA-61-1913-01 OVARY c.2481G>A p.L827L COSMIC NP NP 98 TCGA-66-2758-01 LUNG c.2304G>T p.L768L COSMIC NP NP 99 TCGA-66-2778-01 LUNG c.3392G>C p.R1131T COSMIC PASSENGER/OTHER Benign 100 TCGA-66-2786-01 LUNG c.1458C>T p.F486F COSMIC NP NP 101 TCGA-67-3771-01 LUNG c.841A>G p.R281G COSMIC PASSENGER/OTHER Benign 102 TCGA-69-7765-01 LUNG c.4060G>C p.E1354Q COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-69-7974-01 LUNG c.1395T>A p.S465R COSMIC PASSENGER/OTHER Probably Damaging 104 TCGA-85-6175-01 LUNG c.1054C>T p.P352S COSMIC PASSENGER/OTHER Benign 105 TCGA-86-6851-01 LUNG c.2697A>G p.I899M COSMIC PASSENGER/OTHER Benign 106 TCGA-A5-A0VP-01 ENDOMETRIUM c.253C>T p.Q85* COSMIC NP NP 107 TCGA-A6-3809-01 LARGE INTESTINE c.189A>C p.K63N COSMIC CANCER Probably Damaging 108 TCGA-A6-5665-01 LARGE INTESTINE c.3987G>T p.Q1329H COSMIC PASSENGER/OTHER Probably Damaging 109 TCGA-AA-3516-01 LARGE INTESTINE c.4263G>A p.T1421T COSMIC NP NP 110 TCGA-AA-3518-01 LARGE INTESTINE c.4212C>T p.G1404G COSMIC NP NP 111 TCGA-AA-3833-01 LARGE INTESTINE c.2754T>C p.C918C COSMIC NP NP 112 TCGA-AA-3864-01 LARGE INTESTINE c.67C>T p.P23S COSMIC CANCER Benign 113 TCGA-AA-3947-01 LARGE INTESTINE c.2728A>G p.S910G COSMIC PASSENGER/OTHER Benign 114 TCGA-AA-3977-01 LARGE INTESTINE c.2659G>A p.D887N COSMIC PASSENGER/OTHER Possibly Damaging 115 TCGA-AA-A00E-01 LARGE INTESTINE c.1684A>G p.R562G COSMIC PASSENGER/OTHER Probably Damaging 116 TCGA-AA-A00N-01 LARGE INTESTINE c.986G>A p.R329K COSMIC PASSENGER/OTHER Benign 117 TCGA-AA-A010-01 LARGE INTESTINE c.1761G>T p.E587D COSMIC PASSENGER/OTHER Probably Damaging 118 TCGA-AA-A01R-01 LARGE INTESTINE c.3144G>A p.P1048P COSMIC NP NP 119 TCGA-AA-A01R-01 LARGE INTESTINE c.3558G>A p.P1186P COSMIC NP NP 120 TCGA-AG-3580-01 LARGE INTESTINE c.277G>A p.D93N COSMIC PASSENGER/OTHER Possibly Damaging 121 TCGA-AG-A002-01 LARGE INTESTINE c.3217C>T p.R1073W COSMIC PASSENGER/OTHER Probably Damaging 122 TCGA-AN-A0XO-01 BREAST c.483C>A p.H161Q COSMIC PASSENGER/OTHER Probably Damaging 123 TCGA-AP-A056-01 ENDOMETRIUM c.122A>C p.K41T COSMIC CANCER Probably Damaging 124 TCGA-AP-A056-01 ENDOMETRIUM c.2271G>T p.E757D COSMIC PASSENGER/OTHER Probably Damaging 125 TCGA-AP-A056-01 ENDOMETRIUM c.2725A>C p.I909L COSMIC PASSENGER/OTHER Benign 126 TCGA-AP-A0LI-01 ENDOMETRIUM c.2946G>A p.L982L COSMIC NP NP 127 TCGA-AP-A0LM-01 ENDOMETRIUM c.118A>C p.N40H COSMIC CANCER Probably Damaging 128 TCGA-AP-A0LM-01 ENDOMETRIUM c.1853G>T p.R618I COSMIC PASSENGER/OTHER Possibly Damaging 129 TCGA-AP-A0LM-01 ENDOMETRIUM c.917A>G p.E306G COSMIC PASSENGER/OTHER Probably Damaging 130 TCGA-AX-A05Z-01 ENDOMETRIUM c.252A>G p.E84E COSMIC NP NP 131 TCGA-AX-A064-01 ENDOMETRIUM c.1283G>A p.S428N COSMIC PASSENGER/OTHER Benign 132 TCGA-AX-A0J0-01 ENDOMETRIUM c.3163C>T p.R1055* COSMIC NP NP 133 TCGA-AX-A0J1-01 ENDOMETRIUM c.1018G>A p.A340T COSMIC PASSENGER/OTHER Probably Damaging 134 TCGA-B5-A0JY-01 ENDOMETRIUM c.1421C>A p.S474Y COSMIC PASSENGER/OTHER Probably Damaging 135 TCGA-B5-A0JY-01 ENDOMETRIUM c.2797C>A p.L933I COSMIC PASSENGER/OTHER Probably Damaging 136 TCGA-B5-A11G-01 ENDOMETRIUM c.2736A>G p.Q912Q COSMIC NP NP 137 TCGA-B5-A11R-01 ENDOMETRIUM c.2894G>A p.G965E COSMIC PASSENGER/OTHER Probably Damaging 138 TCGA-BS-A0TC-01 ENDOMETRIUM c.2274A>C p.K758N COSMIC PASSENGER/OTHER Probably Damaging 139 TCGA-BS-A0TC-01 ENDOMETRIUM c.346C>A p.L116I COSMIC PASSENGER/OTHER Possibly Damaging 140 TCGA-BS-A0UF-01 ENDOMETRIUM c.2064A>C p.K688N COSMIC PASSENGER/OTHER Probably Damaging 141 TCGA-BS-A0UF-01 ENDOMETRIUM c.896T>G p.F299C COSMIC PASSENGER/OTHER Probably Damaging 142 TCGA-BS-A0UV-01 ENDOMETRIUM c.3797C>A p.S1266Y COSMIC PASSENGER/OTHER Possibly Damaging 143 TCGA-C8-A27B-01 BREAST c.4321G>A p.E1441K COSMIC PASSENGER/OTHER Probably Damaging 144 TCGA-CA-6717-01 LARGE INTESTINE c.65C>T p.S22L COSMIC CANCER Benign 145 TCGA-CF-A1HS-01 URINARY TRACT c.1102C>T p.H368Y COSMIC PASSENGER/OTHER Benign 146 TCGA-CK-5916-01 LARGE INTESTINE c.2296C>A p.L766M COSMIC PASSENGER/OTHER Probably Damaging 147 TCGA-CW-6087-01 KIDNEY c.321A>G p.I107M COSMIC PASSENGER/OTHER Probably Damaging 148 TCGA-D1-A103-01 ENDOMETRIUM c.2692G>A p.A898T COSMIC PASSENGER/OTHER Benign 149 TCGA-D1-A16B-01 ENDOMETRIUM c.184G>T p.V62L COSMIC CANCER Possibly Damaging 150 TCGA-D1-A17Q-01 ENDOMETRIUM c.2092A>C p.S698R COSMIC PASSENGER/OTHER Possibly Damaging 151 TCGA-D5-5541-01 LARGE INTESTINE c.2586T>C p.T862T COSMIC NP NP 152 TCGA-D5-5541-01 LARGE INTESTINE c.2588C>T p.S863F COSMIC PASSENGER/OTHER Benign 153 TCGA-D5-6529-01 LARGE INTESTINE c.92C>T p.T31M COSMIC CANCER Probably Damaging 154 TCGA-D5-6540-01 LARGE INTESTINE c.1948A>G p.I650V COSMIC PASSENGER/OTHER Benign 155 TCGA-DR-A0ZM-01 CERVIX c.412G>C p.E138Q COSMIC PASSENGER/OTHER Probably Damaging 156 TCGA-G2-A2EC-01 URINARY TRACT c.1769C>G p.S590* COSMIC NP NP 157 TCGA-G4-6309-01 LARGE INTESTINE c.1068T>C p.P356P COSMIC NP NP 158 TCGA-GD-A3OP-01 URINARY TRACT c.1582A>G p.N528D COSMIC PASSENGER/OTHER Benign 159 YUAVEY SKIN c.2668C>T p.P890S COSMIC PASSENGER/OTHER Probably Damaging 160 YUKARN SKIN c.3715C>T p.P1239S COSMIC PASSENGER/OTHER Benign 161 YURDE SKIN c.3715C>T p.P1239S COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Sequence alignment with CCLE mutants:3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
