dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: NCOA3 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 22RV1 PROSTATE c.3763_3765delCAG p.Q1276del CCLE NP NP 2 2313287 STOMACH c.3763_3765delCAG p.Q1276del CCLE NP NP 3 5637 URINARY TRACT c.3790_3792delCAA p.Q1276del CCLE NP NP 4 639V URINARY TRACT c.3763_3765delCAG p.Q1276del CCLE NP NP 5 697 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 6 A172 CENTRAL NERVOUS SYSTEM c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 7 A253 SALIVARY GLAND c.3763_3765delCAG p.Q1276del CCLE NP NP 8 A4FUK HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 9 A673 BONE c.3763_3765delCAG p.Q1276del CCLE NP NP 10 A704 KIDNEY c.3763_3765delCAG p.Q1276del CCLE NP NP 11 ABC1 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 12 ACCS URINARY TRACT c.3763_3765delCAG p.Q1276del CCLE NP NP 13 AM38 CENTRAL NERVOUS SYSTEM c.3763_3765delCAG p.Q1276del CCLE NP NP 14 AML193 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 15 AMO1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 16 AN3CA ENDOMETRIUM c.3763_3765delCAG p.Q1276del CCLE NP NP 17 ASPC1 PANCREAS c.3763_3765delCAG p.Q1276del CCLE NP NP 18 BCP1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 19 BDCM HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 20 BECKER CENTRAL NERVOUS SYSTEM c.3763_3765delCAG p.Q1276del CCLE NP NP 21 BEN LUNG c.3787_3792delCAGCAA p.QQ1275del CCLE NP NP 22 BFTC909 KIDNEY c.3763_3765delCAG p.Q1276del CCLE NP NP 23 BICR16 UPPER AERODIGESTIVE TRACT c.3763_3765delCAG p.Q1276del CCLE NP NP 24 BICR31 UPPER AERODIGESTIVE TRACT c.2701A>C p.S901R CCLE PASSENGER/OTHER Benign 25 BICR31 UPPER AERODIGESTIVE TRACT c.3763_3765delCAG p.Q1276del CCLE NP NP 26 BT549 BREAST c.3763_3765delCAG p.Q1276del CCLE NP NP 27 BV173 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 28 BXPC3 PANCREAS c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 29 CA46 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 30 CAKI2 KIDNEY c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 31 CAL120 BREAST c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 32 CAL148 BREAST c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 33 CAL27 UPPER AERODIGESTIVE TRACT c.3763_3765delCAG p.Q1276del CCLE NP NP 34 CAL29 URINARY TRACT c.3763_3765delCAG p.Q1276del CCLE NP NP 35 CAL33 UPPER AERODIGESTIVE TRACT c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 36 CAL54 KIDNEY c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 37 CAL78 BONE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 38 CAL851 BREAST c.3763_3765delCAG p.Q1276del CCLE NP NP 39 CALU1 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 40 CALU6 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 41 CAPAN1 PANCREAS c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 42 CCFSTTG1 CENTRAL NERVOUS SYSTEM c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 43 CCK81 LARGE INTESTINE c.3790_3792delCAA p.Q1276del CCLE NP NP 44 CFPAC1 PANCREAS c.3790_3792delCAA p.Q1276del CCLE NP NP 45 CGTHW1 THYROID c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 46 CHL1 SKIN c.1601G>A p.G534E CCLE PASSENGER/OTHER Probably Damaging 47 CI1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 48 CL14 LARGE INTESTINE c.3790_3792delCAA p.Q1276del CCLE NP NP 49 CL34 LARGE INTESTINE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 50 CMK115 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 51 CMK HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 52 COLO668 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 53 COLO679 SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 54 COLO680N OESOPHAGUS c.3790_3792delCAA p.Q1276del CCLE NP NP 55 COLO684 ENDOMETRIUM c.3763_3765delCAG p.Q1276del CCLE NP NP 56 COLO704 OVARY c.3763_3765delCAG p.Q1276del CCLE NP NP 57 COLO741 SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 58 COLO741 SKIN c.644C>T p.P215L CCLE PASSENGER/OTHER Benign 59 CORL24 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 60 CORL51 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 61 CORL88 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 62 CORL95 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 63 COV434 OVARY c.3790_3792delCAA p.Q1276del CCLE NP NP 64 COV644 OVARY c.3763_3765delCAG p.Q1276del CCLE NP NP 65 CW2 LARGE INTESTINE c.1522G>A p.A508T CCLE PASSENGER/OTHER Benign 66 CW2 LARGE INTESTINE c.3082C>T p.P1028S CCLE PASSENGER/OTHER Benign 67 DANG PANCREAS c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 68 DAOY CENTRAL NERVOUS SYSTEM c.3763_3765delCAG p.Q1276del CCLE NP NP 69 DAUDI HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 70 DEL HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 71 DKMG CENTRAL NERVOUS SYSTEM c.3763_3765delCAG p.Q1276del CCLE NP NP 72 DMS79 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 73 DOHH2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 74 DV90 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 75 EB2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 76 ECC10 STOMACH c.3790_3792delCAA p.Q1276del CCLE NP NP 77 EFM192A BREAST c.3763_3765delCAG p.Q1276del CCLE NP NP 78 EFO21 OVARY c.3790_3792delCAA p.Q1276del CCLE NP NP 79 EFO27 OVARY c.3763_3765delCAG p.Q1276del CCLE NP NP 80 EJM HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 81 EN ENDOMETRIUM c.995T>C p.V332A CCLE PASSENGER/OTHER Benign 82 ES2 OVARY c.3763_3765delCAG p.Q1276del CCLE NP NP 83 FUOV1 OVARY c.3790_3792delCAA p.Q1276del CCLE NP NP 84 G401 SOFT TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 85 G402 SOFT TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 86 GCT SOFT TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 87 GMS10 CENTRAL NERVOUS SYSTEM c.3763_3765delCAG p.Q1276del CCLE NP NP 88 GOS3 CENTRAL NERVOUS SYSTEM c.3763_3765delCAG p.Q1276del CCLE NP NP 89 H4 CENTRAL NERVOUS SYSTEM c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 90 HCC1143 BREAST c.3763_3765delCAG p.Q1276del CCLE NP NP 91 HCC1395 BREAST c.3790_3792delCAA p.Q1276del CCLE NP NP 92 HCC1428 BREAST c.3763_3765delCAG p.Q1276del CCLE NP NP 93 HCC1500 BREAST c.3790_3792delCAA p.Q1276del CCLE NP NP 94 HCC1569 BREAST c.3790_3792delCAA p.Q1276del CCLE NP NP 95 HCC15 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 96 HCC1954 BREAST c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 97 HCC2157 BREAST c.3790_3792delCAA p.Q1276del CCLE NP NP 98 HCC2935 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 99 HCC366 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 100 HCC38 BREAST c.3790_3792delCAA p.Q1276del CCLE NP NP 101 HCC70 BREAST c.3790_3792delCAA p.Q1276del CCLE NP NP 102 HCC827 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 103 HDLM2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 104 HEC108 ENDOMETRIUM c.1855_1855delA p.K619fs CCLE NP NP 105 HEC151 ENDOMETRIUM c.3763_3765delCAG p.Q1276del CCLE NP NP 106 HEC251 ENDOMETRIUM c.3790_3792delCAA p.Q1276del CCLE NP NP 107 HEC50B ENDOMETRIUM c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 108 HEC59 ENDOMETRIUM c.3790_3792delCAA p.Q1276del CCLE NP NP 109 HEC6 ENDOMETRIUM c.1210T>C p.S404P CCLE PASSENGER/OTHER Benign 110 HEC6 ENDOMETRIUM c.3569C>A p.A1190E CCLE PASSENGER/OTHER Possibly Damaging 111 HEC6 ENDOMETRIUM c.3790_3792delCAA p.Q1276del CCLE NP NP 112 HEL9217 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 113 HEL HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 114 HH HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 115 HLFA LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 116 HS343T BREAST c.3763_3765delCAG p.Q1276del CCLE NP NP 117 HS611T HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 118 HS706T BONE c.3763_3765delCAG p.Q1276del CCLE NP NP 119 HS746T STOMACH c.3763_3765delCAG p.Q1276del CCLE NP NP 120 HS751T HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 121 HS839T SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 122 HS895T SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 123 HS936T SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 124 HS944T SKIN c.3790_3792delCAA p.Q1276del CCLE NP NP 125 HSC2 UPPER AERODIGESTIVE TRACT c.3763_3765delCAG p.Q1276del CCLE NP NP 126 HSC3 UPPER AERODIGESTIVE TRACT c.3786_3787insCAA p.1276_1277insQ CCLE NP NP 127 HSC4 UPPER AERODIGESTIVE TRACT c.3790_3792delCAA p.Q1276del CCLE NP NP 128 HT1080 SOFT TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 129 HT115 LARGE INTESTINE c.3417G>A p.M1139I CCLE PASSENGER/OTHER Possibly Damaging 130 HT115 LARGE INTESTINE c.3763_3765delCAG p.Q1276del CCLE NP NP 131 HT29 LARGE INTESTINE c.3763_3765delCAG p.Q1276del CCLE NP NP 132 HT55 LARGE INTESTINE c.3763_3765delCAG p.Q1276del CCLE NP NP 133 HTK HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 134 HUH28 BILIARY TRACT c.3757_3762delCAGCAA p.QQ1275del CCLE NP NP 135 HUNS1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 136 HUT102 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 137 HUT78 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 138 IGR37 SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 139 IGR39 SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 140 IGROV1 OVARY c.3790_3792delCAA p.Q1276del CCLE NP NP 141 IM95 STOMACH c.3787_3792delCAGCAA p.QQ1275del CCLE NP NP 142 IMR32 AUTONOMIC GANGLIA c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 143 J82 URINARY TRACT c.3763_3765delCAG p.Q1276del CCLE NP NP 144 JEKO1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 145 JHH2 LIVER c.3790_3792delCAA p.Q1276del CCLE NP NP 146 JHH6 LIVER c.4010C>T p.S1337L CCLE PASSENGER/OTHER Probably Damaging 147 JHOM2B OVARY c.3790_3792delCAA p.Q1276del CCLE NP NP 148 JHUEM1 ENDOMETRIUM c.3790_3792delCAA p.Q1276del CCLE NP NP 149 JK1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.56A>G p.K19R CCLE PASSENGER/OTHER Probably Damaging 150 JL1 PLEURA c.3763_3765delCAG p.Q1276del CCLE NP NP 151 JVM2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 152 K562 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 153 KARPAS299 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 154 KE39 STOMACH c.3763_3765delCAG p.Q1276del CCLE NP NP 155 KG1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 156 KHM1B HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 157 KLE ENDOMETRIUM c.3763_3765delCAG p.Q1276del CCLE NP NP 158 KM12 LARGE INTESTINE c.3763_3765delCAG p.Q1276del CCLE NP NP 159 KMH2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3805_3813delCAGCAACAG p.QQQ1272del CCLE NP NP 160 KMRC2 KIDNEY c.3790_3792delCAA p.Q1276del CCLE NP NP 161 KMRC3 KIDNEY c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 162 KMS27 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 163 KNS60 CENTRAL NERVOUS SYSTEM c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 164 KO52 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3786_3787insCAA p.1276_1277insQ CCLE NP NP 165 KP1NL PANCREAS c.3763_3765delCAG p.Q1276del CCLE NP NP 166 KP1N PANCREAS c.3763_3765delCAG p.Q1276del CCLE NP NP 167 KP2 PANCREAS c.3790_3792delCAA p.Q1276del CCLE NP NP 168 KP3 PANCREAS c.3790_3792delCAA p.Q1276del CCLE NP NP 169 KP4 PANCREAS c.2429C>T p.S810F CCLE CANCER Probably Damaging 170 KPNYN AUTONOMIC GANGLIA c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 171 KU1919 URINARY TRACT c.3790_3792delCAA p.Q1276del CCLE NP NP 172 KYO1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 173 KYSE450 OESOPHAGUS c.3763_3765delCAG p.Q1276del CCLE NP NP 174 KYSE510 OESOPHAGUS c.1970C>T p.S657F CCLE PASSENGER/OTHER Probably Damaging 175 KYSE70 OESOPHAGUS c.3790_3792delCAA p.Q1276del CCLE NP NP 176 L33 PANCREAS c.3790_3792delCAA p.Q1276del CCLE NP NP 177 L428 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 178 LCLC103H LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 179 LN18 CENTRAL NERVOUS SYSTEM c.3784_3792delCAGCAGCAA p.QQQ1274del CCLE NP NP 180 LNCAPCLONEFGC PROSTATE c.1563_1564delCT p.S521fs CCLE NP NP 181 LNCAPCLONEFGC PROSTATE c.3790_3792delCAA p.Q1276del CCLE NP NP 182 LOUCY HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 183 LP1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 184 LS123 LARGE INTESTINE c.3763_3765delCAG p.Q1276del CCLE NP NP 185 LS180 LARGE INTESTINE c.3763_3765delCAG p.Q1276del CCLE NP NP 186 LS411N LARGE INTESTINE c.3784_3792delCAGCAGCAA p.QQQ1274del CCLE NP NP 187 LS513 LARGE INTESTINE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 188 LUDLU1 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 189 M07E HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 190 MCF7 BREAST c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 191 MDAMB231 BREAST c.3763_3765delCAG p.Q1276del CCLE NP NP 192 MDAMB415 BREAST c.3763_3765delCAG p.Q1276del CCLE NP NP 193 MDAMB435S SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 194 MDAMB468 BREAST c.3790_3792delCAA p.Q1276del CCLE NP NP 195 MDAPCA2B PROSTATE c.3790_3792delCAA p.Q1276del CCLE NP NP 196 MDST8 LARGE INTESTINE c.3790_3792delCAA p.Q1276del CCLE NP NP 197 ME1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 198 MELJUSO SKIN c.3790_3792delCAA p.Q1276del CCLE NP NP 199 MEWO SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 200 MFE319 ENDOMETRIUM c.208G>A p.A70T CCLE CANCER Probably Damaging 201 MFE319 ENDOMETRIUM c.3763_3765delCAG p.Q1276del CCLE NP NP 202 MFE319 ENDOMETRIUM c.989_989delC p.T330fs CCLE NP NP 203 MG63 BONE c.3763_3765delCAG p.Q1276del CCLE NP NP 204 MHHCALL2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 205 MHHNB11 AUTONOMIC GANGLIA c.3763_3765delCAG p.Q1276del CCLE NP NP 206 MIAPACA2 PANCREAS c.226G>T p.V76L CCLE CANCER Probably Damaging 207 MIAPACA2 PANCREAS c.234_235GA>AT p.I79L CCLE CANCER Probably Damaging 208 MINO HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 209 MJ HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 210 ML1 THYROID c.3763_3765delCAG p.Q1276del CCLE NP NP 211 MOLM13 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1058G>T p.R353L CCLE PASSENGER/OTHER Possibly Damaging 212 MOLM16 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 213 MOLM6 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 214 MOLP2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 215 MOLP8 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 216 MOLP8 HAEMATOPOIETIC AND LYMPHOID TISSUE c.949C>T p.R317C CCLE PASSENGER/OTHER Possibly Damaging 217 MOLT16 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 218 MONOMAC6 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 219 MPP89 PLEURA c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 220 MUTZ5 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1132C>T p.P378S CCLE PASSENGER/OTHER Benign 221 MV411 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 222 NALM6 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 223 NAMALWA HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 224 NB4 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 225 NCCSTCK140 STOMACH c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 226 NCIH1092 LUNG c.3787_3792delCAGCAA p.QQ1275del CCLE NP NP 227 NCIH1184 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 228 NCIH1299 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 229 NCIH1339 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 230 NCIH1373 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 231 NCIH1385 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 232 NCIH1385 LUNG c.426A>T p.T142T CCLE NP NP 233 NCIH1437 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 234 NCIH1563 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 235 NCIH1581 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 236 NCIH1648 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 237 NCIH1650 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 238 NCIH1694 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 239 NCIH1703 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 240 NCIH1734 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 241 NCIH1755 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 242 NCIH1781 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 243 NCIH1793 LUNG c.1114G>T p.E372* CCLE NP NP 244 NCIH1838 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 245 NCIH1876 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 246 NCIH1915 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 247 NCIH1944 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 248 NCIH1975 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 249 NCIH2009 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 250 NCIH2023 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 251 NCIH2030 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 252 NCIH2073 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 253 NCIH2087 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 254 NCIH2106 LUNG c.1496C>T p.P499L CCLE PASSENGER/OTHER Probably Damaging 255 NCIH211 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 256 NCIH2122 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 257 NCIH2126 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 258 NCIH2170 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 259 NCIH2172 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 260 NCIH2196 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 261 NCIH2227 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 262 NCIH2228 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 263 NCIH2286 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 264 NCIH2291 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 265 NCIH2342 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 266 NCIH23 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 267 NCIH2444 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 268 NCIH2452 PLEURA c.552A>G p.T184T CCLE NP NP 269 NCIH358 LUNG c.3632A>T p.Q1211L CCLE PASSENGER/OTHER Benign 270 NCIH358 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 271 NCIH441 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 272 NCIH446 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 273 NCIH460 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 274 NCIH508 LARGE INTESTINE c.3763_3765delCAG p.Q1276del CCLE NP NP 275 NCIH510 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 276 NCIH522 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 277 NCIH647 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 278 NCIH660 PROSTATE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 279 NCIH661 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 280 NCIH727 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 281 NCIH747 LARGE INTESTINE c.3763_3765delCAG p.Q1276del CCLE NP NP 282 NCIH82 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 283 NCIH838 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 284 NCIH854 LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 285 NH6 AUTONOMIC GANGLIA c.3763_3765delCAG p.Q1276del CCLE NP NP 286 NUDHL1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 287 NUDHL1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.487G>A p.E163K CCLE PASSENGER/OTHER Possibly Damaging 288 OCIAML5 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3784_3792delCAGCAGCAA p.QQQ1274del CCLE NP NP 289 OCILY10 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2677G>C p.D893H CCLE PASSENGER/OTHER Possibly Damaging 290 OCILY10 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 291 OCILY3 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 292 OE19 OESOPHAGUS c.3763_3765delCAG p.Q1276del CCLE NP NP 293 OE21 OESOPHAGUS c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 294 OE33 OESOPHAGUS c.3763_3765delCAG p.Q1276del CCLE NP NP 295 ONS76 CENTRAL NERVOUS SYSTEM c.3790_3792delCAA p.Q1276del CCLE NP NP 296 OUMS23 LARGE INTESTINE c.3763_3765delCAG p.Q1276del CCLE NP NP 297 OV56 OVARY c.3763_3777delCAGCAGCAGCAGCAG p.QQQQQ1270del CCLE NP NP 298 OVCAR4 OVARY c.3763_3765delCAG p.Q1276del CCLE NP NP 299 OVCAR8 OVARY c.3763_3765delCAG p.Q1276del CCLE NP NP 300 OVISE OVARY c.3763_3765delCAG p.Q1276del CCLE NP NP 301 OVK18 OVARY c.1921C>T p.P641S CCLE PASSENGER/OTHER Possibly Damaging 302 OVMANA OVARY c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 303 OVSAHO OVARY c.3763_3765delCAG p.Q1276del CCLE NP NP 304 PANC0213 PANCREAS c.3763_3765delCAG p.Q1276del CCLE NP NP 305 PANC0813 PANCREAS c.3763_3765delCAG p.Q1276del CCLE NP NP 306 PANC1005 PANCREAS c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 307 PATU8902 PANCREAS c.3763_3765delCAG p.Q1276del CCLE NP NP 308 PC14 LUNG c.781C>T p.P261S CCLE PASSENGER/OTHER Benign 309 PFEIFFER HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 310 PK1 PANCREAS c.3790_3792delCAA p.Q1276del CCLE NP NP 311 PL21 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 312 RAJI HAEMATOPOIETIC AND LYMPHOID TISSUE c.3790_3792delCAA p.Q1276del CCLE NP NP 313 RCHACV HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 314 RERFLCKJ LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 315 RERFLCSQ1 LUNG c.4084A>G p.M1362V CCLE PASSENGER/OTHER Benign 316 RI1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 317 RKO LARGE INTESTINE c.3790_3792delCAA p.Q1276del CCLE NP NP 318 RPMI7951 SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 319 RPMI8402 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 320 RT4 URINARY TRACT c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 321 SAOS2 BONE c.3790_3792delCAA p.Q1276del CCLE NP NP 322 SCABER URINARY TRACT c.3790_3792delCAA p.Q1276del CCLE NP NP 323 SCC25 UPPER AERODIGESTIVE TRACT c.3763_3765delCAG p.Q1276del CCLE NP NP 324 SCLC21H LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 325 SF295 CENTRAL NERVOUS SYSTEM c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 326 SHP77 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 327 SKES1 BONE c.3763_3765delCAG p.Q1276del CCLE NP NP 328 SKHEP1 LIVER c.3763_3765delCAG p.Q1276del CCLE NP NP 329 SKLMS1 SOFT TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 330 SKLU1 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 331 SKMEL1 SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 332 SKMEL24 SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 333 SKNDZ AUTONOMIC GANGLIA c.3763_3765delCAG p.Q1276del CCLE NP NP 334 SKNFI AUTONOMIC GANGLIA c.3786_3787insCAA p.1276_1277insQ CCLE NP NP 335 SKOV3 OVARY c.955T>G p.Y319D CCLE PASSENGER/OTHER Possibly Damaging 336 SNGM ENDOMETRIUM c.3676G>A p.V1226I CCLE PASSENGER/OTHER Benign 337 SNGM ENDOMETRIUM c.3790_3792delCAA p.Q1276del CCLE NP NP 338 SNU1077 ENDOMETRIUM c.3790_3792delCAA p.Q1276del CCLE NP NP 339 SNU1079 BILIARY TRACT c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 340 SNU1272 KIDNEY c.3790_3804delCAACAGCAACAGCAA p.QQQQQ1269del CCLE NP NP 341 SNU175 LARGE INTESTINE c.256_splice p.G86_splice CCLE NP NP 342 SNU201 CENTRAL NERVOUS SYSTEM c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 343 SNU216 STOMACH c.3787_3792delCAGCAA p.QQ1275del CCLE NP NP 344 SNU423 LIVER c.3763_3765delCAG p.Q1276del CCLE NP NP 345 SNU475 LIVER c.3790_3792delCAA p.Q1276del CCLE NP NP 346 SNU5 STOMACH c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 347 SNU668 STOMACH c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 348 SNU81 LARGE INTESTINE c.2786G>T p.R929I CCLE PASSENGER/OTHER Probably Damaging 349 SNU869 BILIARY TRACT c.3790_3792delCAA p.Q1276del CCLE NP NP 350 SNU886 LIVER c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 351 SR786 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 352 SUDHL4 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 353 SUPB15 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 354 SUPM2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 355 SW1271 LUNG c.3763_3765delCAG p.Q1276del CCLE NP NP 356 SW1417 LARGE INTESTINE c.3763_3765delCAG p.Q1276del CCLE NP NP 357 SW1990 PANCREAS c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 358 SW403 LARGE INTESTINE c.3763_3765delCAG p.Q1276del CCLE NP NP 359 SW480 LARGE INTESTINE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 360 SW579 THYROID c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 361 SW837 LARGE INTESTINE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 362 T173 BONE c.3763_3765delCAG p.Q1276del CCLE NP NP 363 T3M10 LUNG c.3790_3792delCAA p.Q1276del CCLE NP NP 364 TE159T SOFT TISSUE c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 365 TE1 OESOPHAGUS c.3763_3765delCAG p.Q1276del CCLE NP NP 366 TE9 OESOPHAGUS c.3790_3792delCAA p.Q1276del CCLE NP NP 367 TOLEDO HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 368 TOV21G OVARY c.3763_3765delCAG p.Q1276del CCLE NP NP 369 TT OESOPHAGUS c.3763_3765delCAG p.Q1276del CCLE NP NP 370 TT THYROID c.3763_3765delCAG p.Q1276del CCLE NP NP 371 U266B1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3763_3765delCAG p.Q1276del CCLE NP NP 372 UACC257 SKIN c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 373 UACC62 SKIN c.3763_3765delCAG p.Q1276del CCLE NP NP 374 UACC893 BREAST c.3763_3765delCAG p.Q1276del CCLE NP NP 375 UMUC3 URINARY TRACT c.3763_3765delCAG p.Q1276del CCLE NP NP 376 VMRCLCD LUNG c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 377 VMRCRCW KIDNEY c.3790_3792delCAA p.Q1276del CCLE NP NP 378 VMRCRCZ KIDNEY c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 379 WM793 SKIN c.3741_3749delGCAGCAGCA p.QQQ1272del CCLE NP NP 380 YD10B UPPER AERODIGESTIVE TRACT c.3790_3792delCAA p.Q1276del CCLE NP NP 381 YD15 SALIVARY GLAND c.2338G>C p.E780Q CCLE PASSENGER/OTHER Benign 382 YKG1 CENTRAL NERVOUS SYSTEM c.3763_3765delCAG p.Q1276del CCLE NP NP 383 ZR7530 BREAST c.3790_3792delCAA p.Q1276del CCLE NP NP 384 587278 LARGE INTESTINE c.107G>A p.R36Q COSMIC CANCER Possibly Damaging 385 587378 LARGE INTESTINE c.580A>C p.T194P COSMIC PASSENGER/OTHER Probably Damaging 386 BN17T LIVER c.20A>G p.N7S COSMIC PASSENGER/OTHER Benign 387 ESO-0061 OESOPHAGUS c.3379C>T p.H1127Y COSMIC PASSENGER/OTHER Benign 388 ESO-0590 OESOPHAGUS c.1401A>C p.P467P COSMIC NP NP 389 ESO-152 OESOPHAGUS c.2759G>A p.W920* COSMIC NP NP 390 H1155 LUNG c.637G>A p.A213T COSMIC PASSENGER/OTHER Benign 391 H358 LUNG c.3632A>T p.Q1211L COSMIC PASSENGER/OTHER Benign 392 HCC2998 LARGE INTESTINE c.3148G>A p.E1050K COSMIC PASSENGER/OTHER Probably Damaging 393 HCC38T LIVER c.3212A>C p.E1071A COSMIC PASSENGER/OTHER Probably Damaging 394 HCC98T LIVER c.996A>G p.V332V COSMIC NP NP 395 HN_62469 UPPER AERODIGESTIVE TRACT c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 396 HN_63080 UPPER AERODIGESTIVE TRACT c.1711C>T p.L571L COSMIC NP NP 397 LC_C6 LUNG c.1778T>A p.L593H COSMIC PASSENGER/OTHER Benign 398 LC_C6 LUNG c.3889G>C p.A1297P COSMIC PASSENGER/OTHER Probably Damaging 399 LUAD-E01014 LUNG c.52C>T p.R18C COSMIC PASSENGER/OTHER Probably Damaging 400 LUAD-NYU252 LUNG c.864C>T p.S288S COSMIC NP NP 401 LUAD-S00484 LUNG c.1813G>T p.G605W COSMIC PASSENGER/OTHER Probably Damaging 402 ME016T SKIN c.1453C>T p.R485C COSMIC PASSENGER/OTHER Probably Damaging 403 MEL-JWCI-WGS-34 SKIN c.212delT p.L72fs*1 COSMIC NP NP 404 MZ7-mel SKIN c.2673G>A p.M891I COSMIC PASSENGER/OTHER Benign 405 NB07C AUTONOMIC GANGLIA c.3100C>A p.L1034M COSMIC PASSENGER/OTHER Probably Damaging 406 NCI-H1770 LUNG c.1496C>T p.P499L COSMIC PASSENGER/OTHER Probably Damaging 407 PA107 PANCREAS c.3313G>A p.D1105N COSMIC PASSENGER/OTHER Possibly Damaging 408 PACA48 PANCREAS c.981T>C p.H327H COSMIC NP NP 409 PD3998a BREAST c.2222T>C p.L741P COSMIC PASSENGER/OTHER Probably Damaging 410 PD4093a BREAST c.2178G>T p.Q726H COSMIC PASSENGER/OTHER Probably Damaging 411 PR-04-3222 PROSTATE c.4213A>G p.M1405V COSMIC PASSENGER/OTHER Benign 412 PR-2762 PROSTATE c.3756G>A p.Q1252Q COSMIC NP NP 413 RK050_C01 LIVER c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 414 SK-OV-3 OVARY c.955T>G p.Y319D COSMIC PASSENGER/OTHER Possibly Damaging 415 SWE-6 PROSTATE c.3938C>A p.P1313Q COSMIC PASSENGER/OTHER Possibly Damaging 416 TARGET-30-PAPZFW AUTONOMIC GANGLIA c.2517G>A p.L839L COSMIC NP NP 417 TCGA-04-1365-01 OVARY c.3595_3596insCTG p.A1200_G1201insA COSMIC NP NP 418 TCGA-05-4395-01 LUNG c.279T>C p.D93D COSMIC NP NP 419 TCGA-05-4396-01 LUNG c.2023G>T p.G675W COSMIC PASSENGER/OTHER Probably Damaging 420 TCGA-05-4397-01 LUNG c.3492A>T p.T1164T COSMIC NP NP 421 TCGA-05-4410-01 LUNG c.4057G>T p.A1353S COSMIC PASSENGER/OTHER Benign 422 TCGA-13-0890-01 OVARY c.3593C>G p.P1198R COSMIC PASSENGER/OTHER Benign 423 TCGA-13-0904-01 OVARY c.1696G>T p.D566Y COSMIC PASSENGER/OTHER Probably Damaging 424 TCGA-18-3414-01 LUNG c.347T>G p.L116R COSMIC PASSENGER/OTHER Probably Damaging 425 TCGA-23-1118-01 OVARY c.1076A>T p.D359V COSMIC PASSENGER/OTHER Benign 426 TCGA-24-1845-01 OVARY c.3389_3413del25 p.Q1131fs*1 COSMIC NP NP 427 TCGA-44-6779-01 LUNG c.3786G>A p.Q1262Q COSMIC NP NP 428 TCGA-49-4514-01 LUNG c.3756G>A p.Q1252Q COSMIC NP NP 429 TCGA-55-7281-01 LUNG c.3786G>A p.Q1262Q COSMIC NP NP 430 TCGA-56-6545-01 LUNG c.4140G>T p.Q1380H COSMIC PASSENGER/OTHER Probably Damaging 431 TCGA-61-1895-01 OVARY c.2154C>T p.D718D COSMIC NP NP 432 TCGA-64-1676-01 LUNG c.2872A>G p.I958V COSMIC PASSENGER/OTHER Benign 433 TCGA-66-2773-01 LUNG c.2410C>T p.L804F COSMIC CANCER Probably Damaging 434 TCGA-69-7765-01 LUNG c.3759G>A p.Q1253Q COSMIC NP NP 435 TCGA-78-7153-01 LUNG c.1323A>G p.S441S COSMIC NP NP 436 TCGA-85-6561-01 LUNG c.2768C>A p.P923Q COSMIC CANCER Benign 437 TCGA-91-6829-01 LUNG c.3335G>T p.G1112V COSMIC PASSENGER/OTHER Possibly Damaging 438 TCGA-99-8025-01 LUNG c.436C>T p.Q146* COSMIC NP NP 439 TCGA-A1-A0SD-01 BREAST c.3760_3762delCAA p.Q1254delQ COSMIC NP NP 440 TCGA-A2-A1FV-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 441 TCGA-A3-3373-01 KIDNEY c.774A>T p.R258S COSMIC PASSENGER/OTHER Possibly Damaging 442 TCGA-A5-A0GA-01 ENDOMETRIUM c.3786G>A p.Q1262Q COSMIC NP NP 443 TCGA-A6-5656-01 LARGE INTESTINE c.3783G>A p.Q1261Q COSMIC NP NP 444 TCGA-A6-5666-01 LARGE INTESTINE c.2110G>A p.E704K COSMIC PASSENGER/OTHER Probably Damaging 445 TCGA-A7-A26H-01 BREAST c.3178C>T p.L1060F COSMIC PASSENGER/OTHER Benign 446 TCGA-A8-A08T-01 BREAST c.1643T>G p.L548W COSMIC PASSENGER/OTHER Probably Damaging 447 TCGA-A8-A0A7-01 BREAST c.241C>A p.Q81K COSMIC CANCER Possibly Damaging 448 TCGA-AA-3697-01 LARGE INTESTINE c.3789G>A p.Q1263Q COSMIC NP NP 449 TCGA-AA-3821-01 LARGE INTESTINE c.977G>A p.G326D COSMIC PASSENGER/OTHER Probably Damaging 450 TCGA-AA-3864-01 LARGE INTESTINE c.3910G>A p.A1304T COSMIC PASSENGER/OTHER Benign 451 TCGA-AA-3956-01 LARGE INTESTINE c.3799C>G p.Q1267E COSMIC PASSENGER/OTHER Possibly Damaging 452 TCGA-AA-A00N-01 LARGE INTESTINE c.3272A>C p.K1091T COSMIC PASSENGER/OTHER Possibly Damaging 453 TCGA-AA-A00O-01 LARGE INTESTINE c.2983G>A p.A995T COSMIC PASSENGER/OTHER Benign 454 TCGA-AA-A022-01 LARGE INTESTINE c.1835C>A p.P612H COSMIC PASSENGER/OTHER Benign 455 TCGA-AB-2949-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1385delA p.N462fs*2 COSMIC NP NP 456 TCGA-AD-6889-01 LARGE INTESTINE c.3786G>A p.Q1262Q COSMIC NP NP 457 TCGA-AF-2687-01 LARGE INTESTINE c.1560C>A p.S520R COSMIC PASSENGER/OTHER Probably Damaging 458 TCGA-AG-3600-01 LARGE INTESTINE c.438A>G p.Q146Q COSMIC NP NP 459 TCGA-AG-3742-01 LARGE INTESTINE c.3765G>A p.Q1255Q COSMIC NP NP 460 TCGA-AG-A002-01 LARGE INTESTINE c.221A>C p.E74A COSMIC CANCER Probably Damaging 461 TCGA-AG-A002-01 LARGE INTESTINE c.3370G>T p.G1124* COSMIC NP NP 462 TCGA-AG-A002-01 LARGE INTESTINE c.493G>T p.D165Y COSMIC PASSENGER/OTHER Probably Damaging 463 TCGA-AG-A002-01 LARGE INTESTINE c.625G>A p.E209K COSMIC PASSENGER/OTHER Possibly Damaging 464 TCGA-AG-A002-01 LARGE INTESTINE c.857G>A p.R286K COSMIC PASSENGER/OTHER Possibly Damaging 465 TCGA-AO-A0J5-01 BREAST c.3741_3749delGCAGCAGCA p.Q1274_Q1276delQQQ COSMIC NP NP 466 TCGA-AO-A1KO-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 467 TCGA-AP-A054-01 ENDOMETRIUM c.3771G>A p.Q1257Q COSMIC NP NP 468 TCGA-AP-A056-01 ENDOMETRIUM c.2561G>A p.R854Q COSMIC CANCER Probably Damaging 469 TCGA-AP-A056-01 ENDOMETRIUM c.4016G>T p.R1339I COSMIC PASSENGER/OTHER Probably Damaging 470 TCGA-AP-A059-01 ENDOMETRIUM c.3568G>T p.A1190S COSMIC PASSENGER/OTHER Benign 471 TCGA-AP-A0LM-01 ENDOMETRIUM c.4172G>A p.S1391N COSMIC PASSENGER/OTHER Benign 472 TCGA-AR-A0TQ-01 BREAST c.1625C>T p.S542L COSMIC PASSENGER/OTHER Possibly Damaging 473 TCGA-AR-A24V-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 474 TCGA-AR-A252-01 BREAST c.3741_3749delGCAGCAGCA p.Q1274_Q1276delQQQ COSMIC NP NP 475 TCGA-AR-A252-01 BREAST c.3760_3762delCAA p.Q1254delQ COSMIC NP NP 476 TCGA-AX-A0J0-01 ENDOMETRIUM c.1373A>C p.N458T COSMIC PASSENGER/OTHER Benign 477 TCGA-AZ-4315-01 LARGE INTESTINE c.210G>A p.A70A COSMIC NP NP 478 TCGA-AZ-5407-01 LARGE INTESTINE c.1698T>C p.D566D COSMIC NP NP 479 TCGA-AZ-6598-01 LARGE INTESTINE c.3594T>A p.P1198P COSMIC NP NP 480 TCGA-B0-5095-01 KIDNEY c.3565C>G p.Q1189E COSMIC PASSENGER/OTHER Possibly Damaging 481 TCGA-B5-A0JY-01 ENDOMETRIUM c.3512G>T p.R1171I COSMIC PASSENGER/OTHER Probably Damaging 482 TCGA-B5-A11E-01 ENDOMETRIUM c.3801G>T p.Q1267H COSMIC PASSENGER/OTHER Possibly Damaging 483 TCGA-B5-A11R-01 ENDOMETRIUM c.1110G>C p.Q370H COSMIC PASSENGER/OTHER Benign 484 TCGA-BG-A0VX-01 ENDOMETRIUM c.3357G>A p.G1119G COSMIC NP NP 485 TCGA-BH-A0H9-01 BREAST c.3762A>G p.Q1254Q COSMIC NP NP 486 TCGA-BH-A0WA-01 BREAST c.1234C>G p.P412A COSMIC PASSENGER/OTHER Benign 487 TCGA-BH-A1F6-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 488 TCGA-BP-5183-01 KIDNEY c.2808C>G p.N936K COSMIC PASSENGER/OTHER Benign 489 TCGA-BS-A0UF-01 ENDOMETRIUM c.1285A>C p.S429R COSMIC PASSENGER/OTHER Benign 490 TCGA-BS-A0UJ-01 ENDOMETRIUM c.1616C>T p.S539F COSMIC PASSENGER/OTHER Possibly Damaging 491 TCGA-BT-A20T-01 URINARY TRACT c.1931C>G p.S644* COSMIC NP NP 492 TCGA-C8-A274-01 BREAST c.526T>C p.S176P COSMIC PASSENGER/OTHER Benign 493 TCGA-CA-5254-01 LARGE INTESTINE c.857_858insA p.S287fs*8 COSMIC NP NP 494 TCGA-CA-6717-01 LARGE INTESTINE c.122A>G p.E41G COSMIC CANCER Probably Damaging 495 TCGA-CM-6162-01 LARGE INTESTINE c.4140G>A p.Q1380Q COSMIC NP NP 496 TCGA-CM-6171-01 LARGE INTESTINE c.930G>A p.G310G COSMIC NP NP 497 TCGA-D1-A17Q-01 ENDOMETRIUM c.993A>G p.P331P COSMIC NP NP 498 TCGA-D5-6540-01 LARGE INTESTINE c.2673G>A p.M891I COSMIC PASSENGER/OTHER Benign 499 TCGA-D5-6927-01 LARGE INTESTINE c.3611C>T p.A1204V COSMIC PASSENGER/OTHER Benign 500 TCGA-D5-6930-01 LARGE INTESTINE c.3792A>G p.Q1264Q COSMIC NP NP 501 TCGA-D8-A140-01 BREAST c.4010C>T p.S1337L COSMIC PASSENGER/OTHER Probably Damaging 502 TCGA-D8-A1JB-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 503 TCGA-D8-A1JH-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 504 TCGA-D8-A1JJ-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 505 TCGA-D8-A1XC-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 506 TCGA-D8-A1XR-01 BREAST c.3760_3762delCAA p.Q1254delQ COSMIC NP NP 507 TCGA-D8-A1XT-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 508 TCGA-D8-A1Y0-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 509 TCGA-D8-A27H-01 BREAST c.3047C>G p.S1016C COSMIC PASSENGER/OTHER Probably Damaging 510 TCGA-DM-A1DB-01 LARGE INTESTINE c.1496C>A p.P499H COSMIC PASSENGER/OTHER Probably Damaging 511 TCGA-DM-A1DB-01 LARGE INTESTINE c.1497T>C p.P499P COSMIC NP NP 512 TCGA-DM-A28E-01 LARGE INTESTINE c.1496C>T p.P499L COSMIC PASSENGER/OTHER Probably Damaging 513 TCGA-E2-A1IE-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 514 TCGA-E9-A1N9-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 515 TCGA-E9-A1RA-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 516 TCGA-E9-A1RF-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 517 TCGA-EF-5830-01 LARGE INTESTINE c.1496C>A p.P499H COSMIC PASSENGER/OTHER Probably Damaging 518 TCGA-EF-5830-01 LARGE INTESTINE c.1497T>C p.P499P COSMIC NP NP 519 TCGA-EJ-7315-01 PROSTATE c.3756G>A p.Q1252Q COSMIC NP NP 520 TCGA-EJ-7328-01 PROSTATE c.3756G>A p.Q1252Q COSMIC NP NP 521 TCGA-EW-A1J1-01 BREAST c.3763_3765delCAG p.Q1255delQ COSMIC NP NP 522 TCGA-EW-A1OZ-01 BREAST c.3733_3735delATG p.M1247delM COSMIC NP NP 523 TCGA-EW-A1PG-01 BREAST c.3760_3762delCAA p.Q1254delQ COSMIC NP NP 524 TCGA-F4-6856-01 LARGE INTESTINE c.1395delC p.P467fs*15 COSMIC NP NP 525 TCGA-G2-A2ES-01 URINARY TRACT c.3786G>A p.Q1262Q COSMIC NP NP 526 TCGA-G4-6626-01 LARGE INTESTINE c.3759G>A p.Q1253Q COSMIC NP NP 527 TCGA-GD-A3OP-01 URINARY TRACT c.487G>A p.E163K COSMIC PASSENGER/OTHER Possibly Damaging 528 TCGA-GD-A3OP-01 URINARY TRACT c.493G>A p.D165N COSMIC PASSENGER/OTHER Probably Damaging 529 TCGA-H4-A2HQ-01 URINARY TRACT c.3840C>T p.F1280F COSMIC NP NP 530 TCGA-HI-7171-01 PROSTATE c.3759G>A p.Q1253Q COSMIC NP NP 531 TCGA-J2-8194-01 LUNG c.1816G>T p.A606S COSMIC PASSENGER/OTHER Benign 532 YUDUTY SKIN c.1160T>C p.I387T COSMIC PASSENGER/OTHER Benign 533 YUPAT SKIN c.2828G>A p.G943E COSMIC PASSENGER/OTHER Benign 534 YURIF SKIN c.3881G>A p.G1294E COSMIC PASSENGER/OTHER Probably Damaging 535 YURTHE SKIN c.1655C>T p.P552L COSMIC PASSENGER/OTHER Possibly Damaging 536 pfg008T STOMACH c.2066T>C p.L689P COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
1. PFAM Domains:Domain ID Domain Name Start Site End Site E-value PF00989 PAS 116 173 2.2e-08 PF14598 PAS_11 265 375 7.8e-32 PB009106 Pfam-B_9106 420 592 4.3e-15 PF08832 SRC-1 616 704 6e-24 PB014009 Pfam-B_14009 794 924 6.9e-39 PF08815 Nuc_rec_co-act 1045 1095 2.5e-25 PB010879 Pfam-B_10879 1096 1195 3.5e-58 2. Superfamily Domains:Domain ID Start Site End Site E-value 0053766 1042 1090 2.16e-17 0048579 265 370 5.52e-17 0048579 121 186 3.93e-13 0035101 34 90 3.34e-06 -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 101 S Phosphorylation 2 102 S Phosphorylation 3 1033 S Phosphorylation 4 1042 S Phosphorylation 5 1048 S Phosphorylation 6 1059 T Phosphorylation 7 1062 S Phosphorylation 8 1064 T Phosphorylation 9 1067 T Phosphorylation 10 1091 K Methylation 11 1114 T Phosphorylation 12 1194 K Sumoylation 13 1329 S Phosphorylation 14 1330 S Phosphorylation 15 1357 Y Phosphorylation 16 214 S Phosphorylation 17 214 S Phosphorylation 18 24 T Phosphorylation 19 251 R Methylation 20 274 S Phosphorylation 21 282 T Phosphorylation 22 284 S Phosphorylation 23 287 S Phosphorylation 24 288 S Phosphorylation 25 429 S Phosphorylation 26 505 S Phosphorylation 27 505 S Phosphorylation (MAPK14) 28 509 S Phosphorylation 29 543 S Phosphorylation 30 543 S Phosphorylation (MAPK14) 31 551 S Phosphorylation 32 551 S Phosphorylation 33 601 S Phosphorylation 34 601 S Phosphorylation 35 616 K Acetylation 36 616 K Acetylation 37 619 K Acetylation 38 619 K Acetylation 39 620 K Acetylation 40 620 K Acetylation 41 687 K Acetylation 42 687 K Acetylation 43 694 S Phosphorylation 44 723 K Sumoylation 45 728 S Phosphorylation 46 728 S Phosphorylation 47 786 K Sumoylation 48 840 K Methylation 49 857 S Phosphorylation 50 857 S Phosphorylation (CHUK) 51 857 S Phosphorylation (IKBKB) 52 857 S Phosphorylation 53 860 S Phosphorylation 54 860 S Phosphorylation (MAPK14) 55 863 S Phosphorylation 56 866 S Phosphorylation 57 867 S Phosphorylation 58 867 S Phosphorylation (MAPK14) 59 867 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR NCOA3 NCOA3 NCOA3 ENSP00000361065 Q9Y6Q9 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9Y6Q9 NCOA3 ENSP00000361065 NCOA3 Q9Y6Q9 Expression Atlas Protein Atlas OMIM IntAct PharmGKB NCOA3 ENSP00000361065 601937 Q9Y6Q9 PA31472
