dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: NFRKB |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 1 OVARY c.3220A>C p.K1074Q COSMIC NP Probably Damaging 2 587228 LARGE INTESTINE c.3512C>A p.S1171Y COSMIC NP NP 3 587284 LARGE INTESTINE c.1831G>A p.A611T COSMIC NP Probably Damaging 4 587332 LARGE INTESTINE c.109C>T p.R37C COSMIC NP NP 5 587376 LARGE INTESTINE c.3244G>T p.A1082S COSMIC NP Benign 6 8012424 PANCREAS c.908T>G p.L303W COSMIC NP NP 7 BN24T LIVER c.1105G>A p.A369T COSMIC NP NP 8 ESO-0292 OESOPHAGUS c.1835C>T p.A612V COSMIC NP NP 9 ESO-0292 OESOPHAGUS c.817G>T p.D273Y COSMIC NP Probably Damaging 10 ESO-081 OESOPHAGUS c.2005C>T p.R669* COSMIC NP NP 11 ESO-1059 OESOPHAGUS c.2630_2631insCAGT p.M878fs*40 COSMIC NP NP 12 ESO-2143 OESOPHAGUS c.2910C>T p.F970F COSMIC NP NP 13 ESO-717 OESOPHAGUS c.1607G>A p.R536H COSMIC NP NP 14 ESO-859 OESOPHAGUS c.3163A>G p.S1055G COSMIC NP Benign 15 ESO-859 OESOPHAGUS c.3335C>T p.T1112M COSMIC NP NP 16 ESO-859 OESOPHAGUS c.3823C>T p.L1275F COSMIC NP NP 17 H1155 LUNG c.1804G>A p.V602I COSMIC NP NP 18 HX4T LIVER c.1224A>G p.L408L COSMIC NP NP 19 ICGC_0016 PANCREAS c.908T>G p.L303W COSMIC NP NP 20 LUAD-CHTN-MAD04-00674 LUNG c.3853C>T p.R1285C COSMIC NP NP 21 LUAD-F00257 LUNG c.3558C>T p.T1186T COSMIC NP NP 22 LUAD-S01315 LUNG c.2774C>T p.S925F COSMIC NP NP 23 LUAD-S01357 LUNG c.2112delA p.K704fs*8 COSMIC NP NP 24 LUAD-YINHD LUNG c.2037G>A p.R679R COSMIC NP NP 25 ME029T SKIN c.3908C>T p.S1303F COSMIC NP NP 26 OV207 OVARY c.599G>A p.R200Q COSMIC NP NP 27 PA285 PANCREAS c.2440G>A p.A814T COSMIC NP NP 28 S00827 LUNG c.524G>T p.R175L COSMIC NP NP 29 S00837 LUNG c.776G>T p.R259L COSMIC NP NP 30 S00936 LUNG c.1299G>A p.S433S COSMIC NP NP 31 SJMB031 CENTRAL NERVOUS SYSTEM c.2557C>T p.P853S COSMIC NP NP 32 T155 ENDOMETRIUM c.1515G>A p.E505E COSMIC NP NP 33 TARGET-30-PARACS AUTONOMIC GANGLIA c.3546A>T p.T1182T COSMIC NP NP 34 TCGA-13-0727-01 OVARY c.1804G>A p.V602I COSMIC NP NP 35 TCGA-13-1488-01 OVARY c.3439G>C p.G1147R COSMIC NP Probably Damaging 36 TCGA-24-2290-01 OVARY c.3168C>T p.A1056A COSMIC NP NP 37 TCGA-44-7670-01 LUNG c.1912G>C p.D638H COSMIC NP NP 38 TCGA-55-5899-01 LUNG c.1391G>C p.R464P COSMIC NP NP 39 TCGA-66-2778-01 LUNG c.321T>G p.S107R COSMIC NP NP 40 TCGA-66-2791-01 LUNG c.169G>T p.E57* COSMIC NP NP 41 TCGA-69-7980-01 LUNG c.43G>A p.D15N COSMIC NP NP 42 TCGA-75-5126-01 LUNG c.1766G>T p.R589L COSMIC NP Probably Damaging 43 TCGA-78-7147-01 LUNG c.1730G>A p.G577D COSMIC NP NP 44 TCGA-91-6830-01 LUNG c.2180C>G p.P727R COSMIC NP NP 45 TCGA-95-7039-01 LUNG c.900G>A p.P300P COSMIC NP NP 46 TCGA-99-8025-01 LUNG c.372C>A p.F124L COSMIC NP NP 47 TCGA-A2-A0CP-01 BREAST c.1153G>A p.E385K COSMIC NP Probably Damaging 48 TCGA-A6-6781-01 LARGE INTESTINE c.1007delA p.K336fs*13 COSMIC NP NP 49 TCGA-AA-3815-01 LARGE INTESTINE c.109C>T p.R37C COSMIC NP NP 50 TCGA-AA-3815-01 LARGE INTESTINE c.1582C>T p.R528W COSMIC NP Probably Damaging 51 TCGA-AA-3864-01 LARGE INTESTINE c.1632G>A p.R544R COSMIC NP NP 52 TCGA-AA-3864-01 LARGE INTESTINE c.3346G>A p.V1116M COSMIC NP NP 53 TCGA-AH-6549-01 LARGE INTESTINE c.3641_3642delCT p.S1214fs*42 COSMIC NP NP 54 TCGA-AN-A0FY-01 BREAST c.748C>T p.R250C COSMIC NP NP 55 TCGA-AO-A1KO-01 BREAST c.1302A>T p.P434P COSMIC NP NP 56 TCGA-AP-A051-01 ENDOMETRIUM c.749G>A p.R250H COSMIC NP NP 57 TCGA-AP-A054-01 ENDOMETRIUM c.2142T>C p.S714S COSMIC NP NP 58 TCGA-AP-A059-01 ENDOMETRIUM c.144A>C p.R48S COSMIC NP NP 59 TCGA-AX-A064-01 ENDOMETRIUM c.735G>A p.P245P COSMIC NP NP 60 TCGA-AX-A0J0-01 ENDOMETRIUM c.3665G>A p.G1222D COSMIC NP NP 61 TCGA-AX-A0J1-01 ENDOMETRIUM c.3440G>A p.G1147E COSMIC NP Probably Damaging 62 TCGA-AZ-6601-01 LARGE INTESTINE c.3547G>T p.G1183* COSMIC NP NP 63 TCGA-B0-5400-01 KIDNEY c.2932T>C p.L978L COSMIC NP NP 64 TCGA-B5-A0JY-01 ENDOMETRIUM c.180G>T p.E60D COSMIC NP Benign 65 TCGA-B5-A0JY-01 ENDOMETRIUM c.2297C>T p.S766L COSMIC NP Possibly Damaging 66 TCGA-B5-A11N-01 ENDOMETRIUM c.1922G>A p.S641N COSMIC NP NP 67 TCGA-B6-A0IO-01 BREAST c.135A>G p.G45G COSMIC NP NP 68 TCGA-BG-A18B-01 ENDOMETRIUM c.2373A>G p.S791S COSMIC NP NP 69 TCGA-BG-A18B-01 ENDOMETRIUM c.2724T>C p.P908P COSMIC NP NP 70 TCGA-BP-4163-01 KIDNEY c.817G>A p.D273N COSMIC NP Probably Damaging 71 TCGA-CA-6717-01 LARGE INTESTINE c.2028T>C p.H676H COSMIC NP NP 72 TCGA-CA-6718-01 LARGE INTESTINE c.1577T>C p.V526A COSMIC NP NP 73 TCGA-CK-5913-01 LARGE INTESTINE c.1007delA p.K336fs*13 COSMIC NP NP 74 TCGA-D1-A103-01 ENDOMETRIUM c.104G>A p.G35D COSMIC NP NP 75 TCGA-D1-A103-01 ENDOMETRIUM c.1626G>T p.E542D COSMIC NP NP 76 TCGA-D1-A163-01 ENDOMETRIUM c.2313C>T p.S771S COSMIC NP NP 77 TCGA-D1-A165-01 ENDOMETRIUM c.3714C>A p.N1238K COSMIC NP NP 78 TCGA-D1-A167-01 ENDOMETRIUM c.3270C>T p.G1090G COSMIC NP NP 79 TCGA-D1-A167-01 ENDOMETRIUM c.610C>T p.R204C COSMIC NP NP 80 TCGA-D1-A17Q-01 ENDOMETRIUM c.1428C>A p.F476L COSMIC NP NP 81 TCGA-D1-A17Q-01 ENDOMETRIUM c.1770G>T p.E590D COSMIC NP NP 82 TCGA-D1-A17Q-01 ENDOMETRIUM c.1825C>T p.R609W COSMIC NP NP 83 TCGA-D5-6539-01 LARGE INTESTINE c.1805T>C p.V602A COSMIC NP NP 84 TCGA-DK-A3IT-01 URINARY TRACT c.76G>C p.E26Q COSMIC NP NP 85 TCGA-EW-A1IZ-01 BREAST c.3487G>A p.V1163M COSMIC NP NP 86 TCGA-F4-6856-01 LARGE INTESTINE c.1007delA p.K336fs*13 COSMIC NP NP 87 TCGA-G4-6625-01 LARGE INTESTINE c.800C>T p.T267M COSMIC NP NP 88 TCGA-G4-6628-01 LARGE INTESTINE c.1940T>A p.V647E COSMIC NP NP 89 TCGA-GV-A3QI-01 URINARY TRACT c.355A>T p.I119F COSMIC NP NP 90 YUDEXA SKIN c.1081_1082CC>TT p.P361L COSMIC NP NP 91 YUZINO SKIN c.3448C>T p.H1150Y COSMIC NP NP 92 cSCCP4 SKIN c.1982C>T p.P661L COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 1022 S Phosphorylation 2 1027 S Phosphorylation 3 1035 T Phosphorylation 4 1199 S Phosphorylation 5 1202 T Phosphorylation 6 1230 T Phosphorylation 7 1237 K Acetylation 8 1237 K Acetylation 9 1273 T O-linked Glycosylation 10 1291 S Phosphorylation 11 1291 S Phosphorylation 12 148 K Ubiquitylation 13 148 K Acetylation 14 176 S Phosphorylation 15 176 S Phosphorylation 16 178 S Phosphorylation 17 226 S Phosphorylation 18 226 S Phosphorylation 19 228 S Phosphorylation 20 228 S Phosphorylation 21 298 S Phosphorylation 22 298 S Phosphorylation 23 351 S Phosphorylation 24 351 S Phosphorylation 25 376 S Phosphorylation 26 376 S Phosphorylation 27 499 T Phosphorylation 28 750 T O-linked Glycosylation 29 768 T Phosphorylation 30 777 S Phosphorylation 31 780 S Phosphorylation 32 799 S Phosphorylation 33 799 S Phosphorylation 34 803 S Phosphorylation 35 803 S Phosphorylation 36 841 T O-linked Glycosylation 37 866 T O-linked Glycosylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR NFRKB NFRKB NFRKB ENSP00000400476 Q6P4R8 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q6P4R8 NFRKB ENSP00000400476 NFRKB Q6P4R8 Expression Atlas Protein Atlas OMIM IntAct PharmGKB NFRKB ENSP00000400476 164013 Q6P4R8 PA31606
