dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: PHF2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 09-125 CENTRAL NERVOUS SYSTEM c.2961_2962ins15 p.T987_P988insPASTT COSMIC NP NP 2 148632 SALIVARY GLAND c.443A>G p.D148G COSMIC PASSENGER/OTHER Probably Damaging 3 1946219 LUNG c.2963_2964ins15 p.T996_S997insTPAST COSMIC NP NP 4 585208 LUNG c.3161G>A p.R1054Q COSMIC PASSENGER/OTHER Possibly Damaging 5 587220 LARGE INTESTINE c.2099C>T p.P700L COSMIC PASSENGER/OTHER Benign 6 587222 LARGE INTESTINE c.136G>A p.D46N COSMIC PASSENGER/OTHER Probably Damaging 7 587222 LARGE INTESTINE c.1559C>T p.T520M COSMIC PASSENGER/OTHER Benign 8 587224 LARGE INTESTINE c.386T>C p.V129A COSMIC PASSENGER/OTHER Benign 9 587228 LARGE INTESTINE c.854G>A p.R285Q COSMIC PASSENGER/OTHER Benign 10 587284 LARGE INTESTINE c.1196C>A p.A399D COSMIC PASSENGER/OTHER Probably Damaging 11 587316 LARGE INTESTINE c.1477A>G p.T493A COSMIC PASSENGER/OTHER Benign 12 587316 LARGE INTESTINE c.1498C>A p.P500T COSMIC PASSENGER/OTHER Benign 13 587342 LARGE INTESTINE c.2099C>T p.P700L COSMIC PASSENGER/OTHER Benign 14 587376 LARGE INTESTINE c.1204C>A p.L402I COSMIC PASSENGER/OTHER Benign 15 BN05T LIVER c.2961C>A p.T987T COSMIC NP NP 16 BN40T LIVER c.170A>G p.H57R COSMIC PASSENGER/OTHER Possibly Damaging 17 CCRF-CEM HAEMATOPOIETIC AND LYMPHOID TISSUE c.281G>A p.R94Q COSMIC PASSENGER/OTHER Benign 18 ESO-0013 OESOPHAGUS c.2488G>A p.A830T COSMIC PASSENGER/OTHER Possibly Damaging 19 ESO-0292 OESOPHAGUS c.159T>C p.C53C COSMIC NP NP 20 ESO15T OESOPHAGUS c.1724C>T p.P575L COSMIC PASSENGER/OTHER Possibly Damaging 21 ESOSCC164T OESOPHAGUS c.209A>G p.K70R COSMIC PASSENGER/OTHER Benign 22 G18 STOMACH c.1613C>A p.A538D COSMIC PASSENGER/OTHER Benign 23 HCC143T LIVER c.2401A>G p.M801V COSMIC PASSENGER/OTHER Possibly Damaging 24 HCC38T LIVER c.2899T>G p.S967A COSMIC PASSENGER/OTHER Benign 25 HN_63021 UPPER AERODIGESTIVE TRACT c.2736A>G p.P912P COSMIC NP NP 26 LAU165 SKIN c.296C>T p.P99L COSMIC CANCER Probably Damaging 27 LC_S11 LUNG c.2436G>T p.Q812H COSMIC PASSENGER/OTHER Probably Damaging 28 LC_S27 LUNG c.2986A>T p.T996S COSMIC PASSENGER/OTHER Benign 29 LUAD-B01811 LUNG c.2700C>T p.D900D COSMIC NP NP 30 LUAD-B01811 LUNG c.3162G>T p.R1054R COSMIC NP NP 31 LUAD-F00162 LUNG c.141A>T p.I47I COSMIC NP NP 32 LUAD-RT-S01477 LUNG c.2088G>C p.K696N COSMIC PASSENGER/OTHER Probably Damaging 33 LUAD-S01302 LUNG c.2676G>T p.R892R COSMIC NP NP 34 LUAD-S01346 LUNG c.110T>C p.V37A COSMIC PASSENGER/OTHER Probably Damaging 35 PR-09-3566 PROSTATE c.2620G>A p.D874N COSMIC PASSENGER/OTHER Probably Damaging 36 S00501 LUNG c.2683delA p.R896fs*64 COSMIC NP NP 37 SJMB020 CENTRAL NERVOUS SYSTEM c.1261G>C p.E421Q COSMIC PASSENGER/OTHER Probably Damaging 38 TCGA-13-2057-01 OVARY c.3038C>T p.P1013L COSMIC PASSENGER/OTHER Benign 39 TCGA-22-1011-01 LUNG c.304G>A p.E102K COSMIC PASSENGER/OTHER Possibly Damaging 40 TCGA-24-0979-01 OVARY c.936C>T p.T312T COSMIC NP NP 41 TCGA-24-2254-01 OVARY c.2610C>T p.F870F COSMIC NP NP 42 TCGA-37-5819-01 LUNG c.310G>C p.V104L COSMIC PASSENGER/OTHER Possibly Damaging 43 TCGA-49-4514-01 LUNG c.1950C>G p.L650L COSMIC NP NP 44 TCGA-55-1596-01 LUNG c.837C>G p.S279S COSMIC NP NP 45 TCGA-55-6970-01 LUNG c.849C>A p.R283R COSMIC NP NP 46 TCGA-55-7283-01 LUNG c.1327G>T p.E443* COSMIC NP NP 47 TCGA-66-2727-01 LUNG c.2730C>T p.V910V COSMIC NP NP 48 TCGA-66-2727-01 LUNG c.851G>T p.W284L COSMIC PASSENGER/OTHER Probably Damaging 49 TCGA-66-2787-01 LUNG c.1084C>G p.Q362E COSMIC PASSENGER/OTHER Possibly Damaging 50 TCGA-78-7539-01 LUNG c.3240G>A p.Q1080Q COSMIC NP NP 51 TCGA-95-7043-01 LUNG c.2303T>G p.L768R COSMIC PASSENGER/OTHER Probably Damaging 52 TCGA-A1-A0SO-01 BREAST c.1726delA p.N576fs*39 COSMIC NP NP 53 TCGA-A2-A0T0-01 BREAST c.372C>T p.T124T COSMIC NP NP 54 TCGA-A6-5662-01 LARGE INTESTINE c.573C>T p.N191N COSMIC NP NP 55 TCGA-A6-6780-01 LARGE INTESTINE c.1353G>A p.P451P COSMIC NP NP 56 TCGA-A6-6781-01 LARGE INTESTINE c.1345G>A p.V449I COSMIC PASSENGER/OTHER Benign 57 TCGA-AA-3516-01 LARGE INTESTINE c.2764C>T p.R922C COSMIC PASSENGER/OTHER Probably Damaging 58 TCGA-AA-3663-01 LARGE INTESTINE c.2850_2851insA p.S954fs*9 COSMIC NP NP 59 TCGA-AA-3837-01 LARGE INTESTINE c.720C>T p.C240C COSMIC NP NP 60 TCGA-AA-3955-01 LARGE INTESTINE c.2961C>A p.T987T COSMIC NP NP 61 TCGA-AA-3977-01 LARGE INTESTINE c.2281G>A p.A761T COSMIC PASSENGER/OTHER Probably Damaging 62 TCGA-AA-A00J-01 LARGE INTESTINE c.281G>A p.R94Q COSMIC PASSENGER/OTHER Benign 63 TCGA-AA-A00N-01 LARGE INTESTINE c.1901A>C p.K634T COSMIC PASSENGER/OTHER Probably Damaging 64 TCGA-AA-A01R-01 LARGE INTESTINE c.1468delA p.K492fs*6 COSMIC NP NP 65 TCGA-AA-A01R-01 LARGE INTESTINE c.1699G>A p.A567T COSMIC PASSENGER/OTHER Possibly Damaging 66 TCGA-AA-A022-01 LARGE INTESTINE c.1524C>A p.P508P COSMIC NP NP 67 TCGA-AB-2854-03 HAEMATOPOIETIC AND LYMPHOID TISSUE c.324G>A p.V108V COSMIC NP NP 68 TCGA-AD-6889-01 LARGE INTESTINE c.2850_2851insAA p.S954fs*7 COSMIC NP NP 69 TCGA-AD-6895-01 LARGE INTESTINE c.996C>T p.F332F COSMIC NP NP 70 TCGA-AD-6964-01 LARGE INTESTINE c.3118A>G p.T1040A COSMIC PASSENGER/OTHER Benign 71 TCGA-AP-A056-01 ENDOMETRIUM c.2563G>A p.D855N COSMIC PASSENGER/OTHER Probably Damaging 72 TCGA-AP-A059-01 ENDOMETRIUM c.720C>T p.C240C COSMIC NP NP 73 TCGA-AP-A0LT-01 ENDOMETRIUM c.2193T>C p.D731D COSMIC NP NP 74 TCGA-AY-6197-01 LARGE INTESTINE c.1087T>C p.F363L COSMIC PASSENGER/OTHER Probably Damaging 75 TCGA-AY-6386-01 LARGE INTESTINE c.2949A>T p.P983P COSMIC NP NP 76 TCGA-AZ-4315-01 LARGE INTESTINE c.1774C>T p.R592* COSMIC NP NP 77 TCGA-AZ-4315-01 LARGE INTESTINE c.1883C>T p.A628V COSMIC PASSENGER/OTHER Possibly Damaging 78 TCGA-AZ-4315-01 LARGE INTESTINE c.824C>T p.S275L COSMIC PASSENGER/OTHER Benign 79 TCGA-AZ-6598-01 LARGE INTESTINE c.548G>A p.S183N COSMIC PASSENGER/OTHER Possibly Damaging 80 TCGA-AZ-6601-01 LARGE INTESTINE c.2459C>T p.A820V COSMIC PASSENGER/OTHER Possibly Damaging 81 TCGA-B5-A11E-01 ENDOMETRIUM c.1981G>A p.A661T COSMIC PASSENGER/OTHER Possibly Damaging 82 TCGA-B5-A11E-01 ENDOMETRIUM c.549C>T p.S183S COSMIC NP NP 83 TCGA-BG-A2AE-01 ENDOMETRIUM c.3089G>A p.G1030D COSMIC PASSENGER/OTHER Possibly Damaging 84 TCGA-BS-A0TA-01 ENDOMETRIUM c.1977C>T p.F659F COSMIC NP NP 85 TCGA-BS-A0TA-01 ENDOMETRIUM c.848G>A p.R283H COSMIC PASSENGER/OTHER Probably Damaging 86 TCGA-BS-A0UA-01 ENDOMETRIUM c.2614G>A p.D872N COSMIC PASSENGER/OTHER Probably Damaging 87 TCGA-BS-A0UF-01 ENDOMETRIUM c.639G>T p.K213N COSMIC PASSENGER/OTHER Probably Damaging 88 TCGA-BS-A0UJ-01 ENDOMETRIUM c.2667T>C p.F889F COSMIC NP NP 89 TCGA-BS-A0UV-01 ENDOMETRIUM c.2682G>T p.K894N COSMIC PASSENGER/OTHER Probably Damaging 90 TCGA-CF-A1HR-01 URINARY TRACT c.615C>T p.F205F COSMIC NP NP 91 TCGA-CM-4743-01 LARGE INTESTINE c.185T>C p.L62S COSMIC PASSENGER/OTHER Probably Damaging 92 TCGA-D1-A103-01 ENDOMETRIUM c.1368C>T p.V456V COSMIC NP NP 93 TCGA-D1-A103-01 ENDOMETRIUM c.2800C>T p.L934L COSMIC NP NP 94 TCGA-D1-A16E-01 ENDOMETRIUM c.2080A>T p.R694W COSMIC PASSENGER/OTHER Probably Damaging 95 TCGA-D1-A16X-01 ENDOMETRIUM c.1645G>A p.E549K COSMIC PASSENGER/OTHER Probably Damaging 96 TCGA-D1-A17Q-01 ENDOMETRIUM c.448G>A p.E150K COSMIC PASSENGER/OTHER Probably Damaging 97 TCGA-D1-A17U-01 ENDOMETRIUM c.1740T>G p.V580V COSMIC NP NP 98 TCGA-D5-6930-01 LARGE INTESTINE c.1559C>T p.T520M COSMIC PASSENGER/OTHER Benign 99 TCGA-EI-6507-01 LARGE INTESTINE c.2545G>A p.A849T COSMIC PASSENGER/OTHER Benign 100 TCGA-EI-6507-01 LARGE INTESTINE c.2562C>T p.V854V COSMIC NP NP 101 TCGA-G4-6309-01 LARGE INTESTINE c.1419G>A p.P473P COSMIC NP NP 102 YUDIALE SKIN c.1000G>A p.G334R COSMIC PASSENGER/OTHER Probably Damaging 103 YUKIL SKIN c.325C>T p.P109S COSMIC PASSENGER/OTHER Benign 104 YUKLAB SKIN c.296C>T p.P99L COSMIC CANCER Probably Damaging 105 YUZEST SKIN c.1616C>T p.S539L COSMIC PASSENGER/OTHER Benign 106 cSCCP4 SKIN c.1415C>T p.P472L COSMIC PASSENGER/OTHER Benign 107 pfg008T STOMACH c.833T>C p.I278T COSMIC PASSENGER/OTHER Possibly Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 1056 S Phosphorylation 2 1056 S Phosphorylation 3 1058 S Phosphorylation 4 1059 S Phosphorylation 5 162 T Phosphorylation 6 175 K Ubiquitylation 7 427 K Ubiquitylation 8 458 S Phosphorylation 9 459 S Phosphorylation 10 474 S Phosphorylation 11 479 T Phosphorylation 12 537 S Phosphorylation 13 539 S Phosphorylation 14 539 S Phosphorylation 15 541 T Phosphorylation 16 625 S Phosphorylation 17 640 S Phosphorylation 18 654 T Phosphorylation 19 655 S Phosphorylation 20 677 Y Phosphorylation 21 681 S Phosphorylation 22 705 S Phosphorylation 23 730 S Phosphorylation 24 733 S Phosphorylation 25 734 S Phosphorylation 26 738 S Phosphorylation 27 757 S Phosphorylation 28 879 S Phosphorylation 29 882 S Phosphorylation 30 882 S Phosphorylation 31 899 S Phosphorylation 32 899 S Phosphorylation 33 904 Y Phosphorylation 34 905 S Phosphorylation 35 954 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR PHF2 PHF2 PHF2 ENSP00000352185 O75151 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O75151 PHF2 ENSP00000352185 PHF2 O75151 Expression Atlas Protein Atlas OMIM IntAct PharmGKB PHF2 ENSP00000352185 604351 O75151 PA33260
