dbEM

Protein: PRMT1

Mutation Data (+)

#	Cell Line/Tumor sample	Tissue of Origin	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	CLL033	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.621C>T	p.A207A	COSMIC	NP	NP
2	ESO-837	OESOPHAGUS	c.255C>T	p.A85A	COSMIC	NP	NP
3	H838	LUNG	c.775G>T	p.A259S	COSMIC	NP	Benign
4	LPJ023	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.19G>T	p.V7L	COSMIC	NP	NP
5	LUAD-F00282	LUNG	c.903G>A	p.V301V	COSMIC	NP	NP
6	MI2	LARGE INTESTINE	c.987G>C	p.L329L	COSMIC	NP	NP
7	PA285	PANCREAS	c.182A>G	p.H61R	COSMIC	NP	NP
8	TCGA-13-0730-01	OVARY	c.448C>T	p.L150F	COSMIC	NP	NP
9	TCGA-23-1116-01	OVARY	c.873G>A	p.T291T	COSMIC	NP	NP
10	TCGA-34-5928-01	LUNG	c.189C>T	p.F63F	COSMIC	NP	NP
11	TCGA-44-2668-01	LUNG	c.630G>A	p.E210E	COSMIC	NP	NP
12	TCGA-49-6767-01	LUNG	c.858G>T	p.T286T	COSMIC	NP	NP
13	TCGA-A6-6781-01	LARGE INTESTINE	c.450C>A	p.L150L	COSMIC	NP	NP
14	TCGA-AA-A00J-01	LARGE INTESTINE	c.975_977delCAC	p.T326delT	COSMIC	NP	NP
15	TCGA-AP-A0LM-01	ENDOMETRIUM	c.594C>T	p.F198F	COSMIC	NP	NP
16	TCGA-AP-A0LM-01	ENDOMETRIUM	c.913G>A	p.E305K	COSMIC	NP	NP
17	TCGA-AX-A0J1-01	ENDOMETRIUM	c.858G>A	p.T286T	COSMIC	NP	NP
18	TCGA-AX-A0J1-01	ENDOMETRIUM	c.949G>A	p.A317T	COSMIC	NP	Benign
19	TCGA-AY-6386-01	LARGE INTESTINE	c.449T>C	p.L150P	COSMIC	NP	NP
20	TCGA-AZ-6601-01	LARGE INTESTINE	c.213C>T	p.V71V	COSMIC	NP	NP
21	TCGA-BH-A0BO-01	BREAST	c.693G>A	p.V231V	COSMIC	NP	NP
22	TCGA-BH-A204-01	BREAST	c.95C>G	p.S32C	COSMIC	NP	NP
23	TCGA-BP-4995-01	KIDNEY	c.273C>T	p.I91I	COSMIC	NP	NP
24	TCGA-BS-A0T9-01	ENDOMETRIUM	c.1040G>A	p.R347H	COSMIC	NP	NP
25	TCGA-BS-A0UA-01	ENDOMETRIUM	c.948C>T	p.N316N	COSMIC	NP	NP
26	TCGA-CK-4952-01	LARGE INTESTINE	c.449T>C	p.L150P	COSMIC	NP	NP
27	TCGA-CM-4744-01	LARGE INTESTINE	c.243T>C	p.F81F	COSMIC	NP	NP
28	TCGA-D1-A17L-01	ENDOMETRIUM	c.699C>G	p.I233M	COSMIC	NP	NP
29	TCGA-D5-6541-01	LARGE INTESTINE	c.464A>G	p.Y155C	COSMIC	NP	NP
30	TCGA-DS-A0VM-01	CERVIX	c.490G>A	p.D164N	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Expression and CNV data is not present for PRMT1!!
Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.

test
Tertiary structure (+)

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Modelled Structure Structures available in PDB

Structure is not available in PDB
Structure Domains (+)

1. PFAM Domains:

Domain ID Domain Name Start Site End Site E-value
PF13847 Methyltransf_31 78 152 1.4e-08
PB009220 Pfam-B_9220 184 342 1.4e-29
PB001639 Pfam-B_1639 235 351 3.7e-08

2. Superfamily Domains:

Domain ID Start Site End Site E-value
0048629 46 360 1.05e-101

Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

Click on button to get Sequence alignment with Coverage, Consensus and Quality

4. Sequence alignment with homologus proteins:

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  Sequence Profiles (+)

HMM
  With Uniprot database     With Mutants      With 1000 Genome Variants
PSSM
  With Uniprot database     With Mutants      With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type
1	121	K	Ubiquitylation
2	124	K	Ubiquitylation
3	133	K	Ubiquitylation
4	173	K	Ubiquitylation
5	223	K	Ubiquitylation
6	233	K	Ubiquitylation
7	262	C	S-nitrosylation
8	299	Y	Phosphorylation
9	299	Y	Phosphorylation
10	303	K	Ubiquitylation
11	332	K	Ubiquitylation

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
PRMT1	PRMT1	PRMT1	ENSP00000375724	Q99873
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
Q99873	PRMT1	ENSP00000375724	PRMT1	Q99873
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
PRMT1	ENSP00000375724	602950	Q99873	PA142672526

Modelled Structure	Structures available in PDB
	Structure is not available in PDB

Domain ID	Domain Name	Start Site	End Site	E-value
PF13847	Methyltransf_31	78	152	1.4e-08
PB009220	Pfam-B_9220	184	342	1.4e-29
PB001639	Pfam-B_1639	235	351	3.7e-08

dbEM

Protein: PRMT1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)