dbEM

Protein: PRMT1

Mutation Data (+)

#	Cell Line/Tumor sample	Tissue of Origin	cDNA change	Protein change	Source	FATHMM Prediction	PolyPhen2 Prediction
1	CLL033	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.621C>T	p.A207A	COSMIC	NP	NP
2	ESO-837	OESOPHAGUS	c.255C>T	p.A85A	COSMIC	NP	NP
3	H838	LUNG	c.775G>T	p.A259S	COSMIC	NP	Benign
4	LPJ023	HAEMATOPOIETIC AND LYMPHOID TISSUE	c.19G>T	p.V7L	COSMIC	NP	NP
5	LUAD-F00282	LUNG	c.903G>A	p.V301V	COSMIC	NP	NP
6	MI2	LARGE INTESTINE	c.987G>C	p.L329L	COSMIC	NP	NP
7	PA285	PANCREAS	c.182A>G	p.H61R	COSMIC	NP	NP
8	TCGA-13-0730-01	OVARY	c.448C>T	p.L150F	COSMIC	NP	NP
9	TCGA-23-1116-01	OVARY	c.873G>A	p.T291T	COSMIC	NP	NP
10	TCGA-34-5928-01	LUNG	c.189C>T	p.F63F	COSMIC	NP	NP
11	TCGA-44-2668-01	LUNG	c.630G>A	p.E210E	COSMIC	NP	NP
12	TCGA-49-6767-01	LUNG	c.858G>T	p.T286T	COSMIC	NP	NP
13	TCGA-A6-6781-01	LARGE INTESTINE	c.450C>A	p.L150L	COSMIC	NP	NP
14	TCGA-AA-A00J-01	LARGE INTESTINE	c.975_977delCAC	p.T326delT	COSMIC	NP	NP
15	TCGA-AP-A0LM-01	ENDOMETRIUM	c.594C>T	p.F198F	COSMIC	NP	NP
16	TCGA-AP-A0LM-01	ENDOMETRIUM	c.913G>A	p.E305K	COSMIC	NP	NP
17	TCGA-AX-A0J1-01	ENDOMETRIUM	c.858G>A	p.T286T	COSMIC	NP	NP
18	TCGA-AX-A0J1-01	ENDOMETRIUM	c.949G>A	p.A317T	COSMIC	NP	Benign
19	TCGA-AY-6386-01	LARGE INTESTINE	c.449T>C	p.L150P	COSMIC	NP	NP
20	TCGA-AZ-6601-01	LARGE INTESTINE	c.213C>T	p.V71V	COSMIC	NP	NP
21	TCGA-BH-A0BO-01	BREAST	c.693G>A	p.V231V	COSMIC	NP	NP
22	TCGA-BH-A204-01	BREAST	c.95C>G	p.S32C	COSMIC	NP	NP
23	TCGA-BP-4995-01	KIDNEY	c.273C>T	p.I91I	COSMIC	NP	NP
24	TCGA-BS-A0T9-01	ENDOMETRIUM	c.1040G>A	p.R347H	COSMIC	NP	NP
25	TCGA-BS-A0UA-01	ENDOMETRIUM	c.948C>T	p.N316N	COSMIC	NP	NP
26	TCGA-CK-4952-01	LARGE INTESTINE	c.449T>C	p.L150P	COSMIC	NP	NP
27	TCGA-CM-4744-01	LARGE INTESTINE	c.243T>C	p.F81F	COSMIC	NP	NP
28	TCGA-D1-A17L-01	ENDOMETRIUM	c.699C>G	p.I233M	COSMIC	NP	NP
29	TCGA-D5-6541-01	LARGE INTESTINE	c.464A>G	p.Y155C	COSMIC	NP	NP
30	TCGA-DS-A0VM-01	CERVIX	c.490G>A	p.D164N	COSMIC	NP	NP

*NP: Not Predicted

Copy number variation and expression profile (+)

Expression and CNV data is not present for PRMT1!!
Gene Essentiality Data (+)

Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.
Tertiary structure (+)

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Modelled Structure Structures available in PDB
Structure Domains (+)

1. PFAM Domains:

2. Superfaimly domains are not present!!
Sequence Alignment (+)

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1. Variants are not present in 1000 Genomes!!

2. Mutants are not present in CCLE!!

3. Sequence alignment with COSMIC mutants:

4. Sequence alignment with homologus proteins:
  Sequence Profiles (+)

HMM
  With Uniprot database     With Mutants      With 1000 Genome Variants
PSSM
  With Uniprot database     With Mutants      With 1000 Genome Variant

Post Translational Modifications (+)

S. No.	Position	Amino acid	Type
1	121	K	Ubiquitylation
2	124	K	Ubiquitylation
3	133	K	Ubiquitylation
4	173	K	Ubiquitylation
5	223	K	Ubiquitylation
6	233	K	Ubiquitylation
7	262	C	S-nitrosylation
8	299	Y	Phosphorylation
9	299	Y	Phosphorylation
10	303	K	Ubiquitylation
11	332	K	Ubiquitylation

Other Databases Link (+)

Proteomics DB COSMIC Gene Atlas STRING PIR

PRMT1 PRMT1 PRMT1

QuickGO HGNC Ensembl Genome Browser TreeFam UniProt

PRMT1 PRMT1

Expression Atlas Protein Atlas OMIM IntAct PharmGKB

PRMT1

CSIR-IMTECH

Raghava's Group

Proteomics DB	COSMIC	Gene Atlas	STRING	PIR
PRMT1	PRMT1	PRMT1
QuickGO	HGNC	Ensembl Genome Browser	TreeFam	UniProt
	PRMT1		PRMT1
Expression Atlas	Protein Atlas	OMIM	IntAct	PharmGKB
PRMT1

Modelled Structure	Structures available in PDB

dbEM

Protein: PRMT1

Mutation Data (+)

Copy number variation and expression profile (+)

Gene Essentiality Data (+)

Tertiary structure (+)

Structure Domains (+)

Sequence Alignment (+)

Sequence Profiles (+)

Post Translational Modifications (+)

Other Databases Link (+)