dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: PRMT2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587234 LARGE INTESTINE c.262G>A p.V88M COSMIC PASSENGER/OTHER Benign 2 587376 LARGE INTESTINE c.1214T>C p.M405T COSMIC PASSENGER/OTHER Possibly Damaging 3 ESO-143 OESOPHAGUS c.48G>A p.E16E COSMIC NP NP 4 H292 LUNG c.29G>T p.S10I COSMIC PASSENGER/OTHER Benign 5 HCC106T LIVER c.833C>A p.S278Y COSMIC PASSENGER/OTHER Probably Damaging 6 HCT-15 LARGE INTESTINE c.301G>T p.E101* COSMIC NP NP 7 HN_62814 UPPER AERODIGESTIVE TRACT c.712G>A p.G238R COSMIC PASSENGER/OTHER Probably Damaging 8 LUAD-5V8LT LUNG c.1170G>T p.T390T COSMIC NP NP 9 LUAD-RT-S01813 LUNG c.1128G>T p.M376I COSMIC PASSENGER/OTHER Probably Damaging 10 LUAD-RT-S01831 LUNG c.902C>G p.S301C COSMIC PASSENGER/OTHER Probably Damaging 11 PD4844a NS c.476C>T p.A159V COSMIC PASSENGER/OTHER Probably Damaging 12 SA067 BREAST c.813C>G p.F271L COSMIC PASSENGER/OTHER Benign 13 TCGA-13-2057-01 OVARY c.842T>G p.V281G COSMIC PASSENGER/OTHER Benign 14 TCGA-23-2645-01 OVARY c.801C>T p.N267N COSMIC NP NP 15 TCGA-24-1604-01 OVARY c.222C>T p.G74G COSMIC NP NP 16 TCGA-60-2722-01 LUNG c.479G>T p.R160L COSMIC PASSENGER/OTHER Possibly Damaging 17 TCGA-A1-A0SO-01 BREAST c.1017C>T p.F339F COSMIC NP NP 18 TCGA-A5-A0GA-01 ENDOMETRIUM c.280G>A p.E94K COSMIC PASSENGER/OTHER Probably Damaging 19 TCGA-A6-6781-01 LARGE INTESTINE c.980G>A p.R327H COSMIC PASSENGER/OTHER Benign 20 TCGA-AA-3672-01 LARGE INTESTINE c.287C>T p.T96M COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-AA-A01P-01 LARGE INTESTINE c.576C>T p.Y192Y COSMIC NP NP 22 TCGA-AN-A0XW-01 BREAST c.857C>G p.S286* COSMIC NP NP 23 TCGA-AP-A051-01 ENDOMETRIUM c.1209G>A p.R403R COSMIC NP NP 24 TCGA-AP-A059-01 ENDOMETRIUM c.435C>A p.G145G COSMIC NP NP 25 TCGA-AZ-4315-01 LARGE INTESTINE c.400G>A p.E134K COSMIC PASSENGER/OTHER Benign 26 TCGA-AZ-6598-01 LARGE INTESTINE c.850delT p.S286fs*9 COSMIC NP NP 27 TCGA-BS-A0UM-01 ENDOMETRIUM c.1287C>T p.F429F COSMIC NP NP 28 TCGA-BS-A0UV-01 ENDOMETRIUM c.1119G>A p.T373T COSMIC NP NP 29 TCGA-CA-6718-01 LARGE INTESTINE c.868T>C p.Y290H COSMIC PASSENGER/OTHER Benign 30 TCGA-DM-A28H-01 LARGE INTESTINE c.27A>C p.R9S COSMIC PASSENGER/OTHER Benign 31 TCGA-E2-A10C-01 BREAST c.1293C>T p.I431I COSMIC NP NP 32 TCGA-F5-6464-01 LARGE INTESTINE c.1138C>T p.P380S COSMIC PASSENGER/OTHER Probably Damaging 33 WA16 PROSTATE c.570C>T p.T190T COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score. -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 125 Y Phosphorylation 2 41 Y Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR PRMT2 PRMT2 PRMT2 ENSP00000291705 P55345 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt P55345 PRMT2 ENSP00000291705 PRMT2 P55345 Expression Atlas Protein Atlas OMIM IntAct PharmGKB PRMT2 ENSP00000291705 601961 P55345 PA29460
