dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: PRMT3 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 2334191 LUNG c.244C>T p.H82Y COSMIC PASSENGER/OTHER Benign 2 CRC-3 LARGE INTESTINE c.1217T>G p.V406G COSMIC PASSENGER/OTHER Benign 3 HCC89T LIVER c.1151A>C p.D384A COSMIC PASSENGER/OTHER Probably Damaging 4 HCT-15 LARGE INTESTINE c.275T>C p.L92P COSMIC CANCER Probably Damaging 5 HX12T LIVER c.1388G>C p.C463S COSMIC PASSENGER/OTHER Probably Damaging 6 LC_S8 LUNG c.1033delC p.L345fs*24 COSMIC NP NP 7 LC_S8 LUNG c.1035delT p.Y346fs*23 COSMIC NP NP 8 LUAD-RT-S01487 LUNG c.794G>T p.G265V COSMIC PASSENGER/OTHER Probably Damaging 9 LUAD-S01315 LUNG c.1414G>T p.G472C COSMIC PASSENGER/OTHER Probably Damaging 10 LUAD-S01478 LUNG c.739A>T p.I247L COSMIC PASSENGER/OTHER Benign 11 LUAD_E00522 LUNG c.118G>A p.D40N COSMIC PASSENGER/OTHER Benign 12 PA285 PANCREAS c.1092T>C p.T364T COSMIC NP NP 13 PACA86 PANCREAS c.570T>A p.A190A COSMIC NP NP 14 PACA86 PANCREAS c.571C>T p.Q191* COSMIC NP NP 15 S00935 LUNG c.916A>T p.I306F COSMIC PASSENGER/OTHER Probably Damaging 16 TCGA-33-4566-01 LUNG c.1477G>C p.V493L COSMIC PASSENGER/OTHER Benign 17 TCGA-38-4625-01 LUNG c.346G>T p.E116* COSMIC NP NP 18 TCGA-44-5644-01 LUNG c.76G>T p.D26Y COSMIC PASSENGER/OTHER Probably Damaging 19 TCGA-50-6590-01 LUNG c.1347G>T p.T449T COSMIC NP NP 20 TCGA-66-2785-01 LUNG c.1105G>A p.A369T COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-66-2785-01 LUNG c.1366G>T p.D456Y COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-95-7947-01 LUNG c.1139T>C p.I380T COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-A6-5665-01 LARGE INTESTINE c.1149G>T p.W383C COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-A6-5665-01 LARGE INTESTINE c.1438T>G p.W480G COSMIC PASSENGER/OTHER Probably Damaging 25 TCGA-A8-A097-01 BREAST c.1537C>T p.R513C COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-AA-3973-01 LARGE INTESTINE c.745C>T p.Q249* COSMIC NP NP 27 TCGA-AA-3977-01 LARGE INTESTINE c.1024G>T p.D342Y COSMIC PASSENGER/OTHER Benign 28 TCGA-AG-A002-01 LARGE INTESTINE c.974T>C p.V325A COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-AP-A051-01 ENDOMETRIUM c.1277C>T p.T426M COSMIC PASSENGER/OTHER Possibly Damaging 30 TCGA-AP-A051-01 ENDOMETRIUM c.833C>T p.A278V COSMIC PASSENGER/OTHER Probably Damaging 31 TCGA-AP-A056-01 ENDOMETRIUM c.195A>G p.S65S COSMIC NP NP 32 TCGA-AP-A059-01 ENDOMETRIUM c.1556T>C p.L519P COSMIC PASSENGER/OTHER Probably Damaging 33 TCGA-AP-A0LM-01 ENDOMETRIUM c.1136G>T p.R379I COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-AP-A0LM-01 ENDOMETRIUM c.609G>A p.S203S COSMIC NP NP 35 TCGA-AX-A05Z-01 ENDOMETRIUM c.834G>A p.A278A COSMIC NP NP 36 TCGA-AX-A0J0-01 ENDOMETRIUM c.716G>A p.R239Q COSMIC PASSENGER/OTHER Probably Damaging 37 TCGA-AX-A0J1-01 ENDOMETRIUM c.1277C>T p.T426M COSMIC PASSENGER/OTHER Possibly Damaging 38 TCGA-B5-A0K2-01 ENDOMETRIUM c.862G>T p.E288* COSMIC NP NP 39 TCGA-BH-A18H-01 BREAST c.1271G>A p.C424Y COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-BP-5187-01 KIDNEY c.1299A>C p.E433D COSMIC PASSENGER/OTHER Benign 41 TCGA-BP-5187-01 KIDNEY c.1304C>T p.S435L COSMIC PASSENGER/OTHER Benign 42 TCGA-BS-A0UF-01 ENDOMETRIUM c.952C>A p.L318I COSMIC PASSENGER/OTHER Probably Damaging 43 TCGA-C8-A134-01 BREAST c.435C>T p.P145P COSMIC NP NP 44 TCGA-CA-6717-01 LARGE INTESTINE c.772G>A p.V258I COSMIC PASSENGER/OTHER Benign 45 TCGA-CM-6168-01 LARGE INTESTINE c.715C>T p.R239* COSMIC NP NP 46 TCGA-D1-A17H-01 ENDOMETRIUM c.949C>T p.H317Y COSMIC PASSENGER/OTHER Benign 47 TCGA-FI-A2D2-01 ENDOMETRIUM c.1245_1246insC p.C417fs*4 COSMIC NP NP 48 WA16 PROSTATE c.204G>A p.K68K COSMIC NP NP 49 YUDATE SKIN c.335C>T p.P112L COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 187 K Ubiquitylation 2 25 S Phosphorylation 3 25 S Phosphorylation 4 27 S Phosphorylation 5 27 S Phosphorylation 6 87 Y Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR PRMT3 PRMT3 PRMT3 ENSP00000331879 O60678 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O60678 PRMT3 ENSP00000331879 PRMT3 O60678 Expression Atlas Protein Atlas OMIM IntAct PharmGKB PRMT3 ENSP00000331879 603190 O60678 PA29462
