dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: PRMT5 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587234 LARGE INTESTINE c.1150C>T p.R384W COSMIC NP Probably Damaging 2 587278 LARGE INTESTINE c.239C>T p.T80M COSMIC NP Probably Damaging 3 631060 LUNG c.858C>A p.Y286* COSMIC NP NP 4 B9 URINARY TRACT c.955C>G p.L319V COSMIC NP Probably Damaging 5 H1155 LUNG c.1895C>T p.S632L COSMIC PASSENGER/OTHER Probably Damaging 6 HCC107T LIVER c.1042C>T p.R348* COSMIC NP NP 7 HN_0-064 UPPER AERODIGESTIVE TRACT c.206C>G p.S69* COSMIC NP NP 8 HN_62755 UPPER AERODIGESTIVE TRACT c.496G>A p.D166N COSMIC NP Benign 9 HN_62810 UPPER AERODIGESTIVE TRACT c.736C>T p.L246F COSMIC NP Probably Damaging 10 MOLT-4 HAEMATOPOIETIC AND LYMPHOID TISSUE c.567G>A p.W189* COSMIC NP NP 11 PD6746a NS c.23delG p.G8fs*13 COSMIC NP NP 12 S00050 LUNG c.993C>A p.P331P COSMIC NP NP 13 TCGA-13-1407-01 OVARY c.1006C>G p.Q336E COSMIC PASSENGER/OTHER Benign 14 TCGA-23-2641-01 OVARY c.659G>A p.R220H COSMIC NP Probably Damaging 15 TCGA-50-5946-01 LUNG c.145C>T p.R49C COSMIC NP Probably Damaging 16 TCGA-50-5946-02 LUNG c.145C>T p.R49C COSMIC NP Probably Damaging 17 TCGA-50-6590-01 LUNG c.15G>T p.A5A COSMIC NP NP 18 TCGA-55-5899-01 LUNG c.190G>T p.G64C COSMIC NP Probably Damaging 19 TCGA-55-6968-01 LUNG c.1443C>A p.Y481* COSMIC NP NP 20 TCGA-78-7166-01 LUNG c.1132G>C p.A378P COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-78-7536-01 LUNG c.1842G>T p.E614D COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-A8-A09X-01 BREAST c.646C>T p.H216Y COSMIC NP Possibly Damaging 23 TCGA-AA-3710-01 LARGE INTESTINE c.888C>A p.A296A COSMIC NP NP 24 TCGA-AA-3864-01 LARGE INTESTINE c.1396G>A p.G466R COSMIC PASSENGER/OTHER Benign 25 TCGA-AA-3950-01 LARGE INTESTINE c.366C>A p.F122L COSMIC NP Benign 26 TCGA-AA-A010-01 LARGE INTESTINE c.897C>A p.L299L COSMIC NP NP 27 TCGA-AP-A051-01 ENDOMETRIUM c.1909C>A p.L637I COSMIC NP Probably Damaging 28 TCGA-AP-A0LG-01 ENDOMETRIUM c.1096G>A p.A366T COSMIC PASSENGER/OTHER Probably Damaging 29 TCGA-AP-A0LM-01 ENDOMETRIUM c.298C>T p.R100C COSMIC NP Benign 30 TCGA-AP-A0LM-01 ENDOMETRIUM c.309C>T p.S103S COSMIC NP NP 31 TCGA-B0-4810-01 KIDNEY c.143C>T p.P48L COSMIC NP Probably Damaging 32 TCGA-B5-A0K3-01 ENDOMETRIUM c.1204G>C p.E402Q COSMIC PASSENGER/OTHER Benign 33 TCGA-B5-A11E-01 ENDOMETRIUM c.272G>A p.R91H COSMIC NP Benign 34 TCGA-BH-A0HX-01 BREAST c.1582C>T p.P528S COSMIC PASSENGER/OTHER Benign 35 TCGA-BP-5176-01 KIDNEY c.1223A>T p.E408V COSMIC PASSENGER/OTHER Possibly Damaging 36 TCGA-BS-A0UV-01 ENDOMETRIUM c.260C>A p.S87Y COSMIC NP Probably Damaging 37 TCGA-C8-A12Q-01 BREAST c.759C>T p.L253L COSMIC NP NP 38 TCGA-CF-A27C-01 URINARY TRACT c.73G>A p.E25K COSMIC NP Possibly Damaging 39 TCGA-CH-5771-01 PROSTATE c.111G>T p.G37G COSMIC NP NP 40 TCGA-D1-A103-01 ENDOMETRIUM c.734T>C p.V245A COSMIC NP Probably Damaging 41 TCGA-D5-6534-01 LARGE INTESTINE c.1007A>G p.Q336R COSMIC PASSENGER/OTHER Benign 42 TCGA-DI-A0WH-01 ENDOMETRIUM c.1407T>C p.T469T COSMIC NP NP 43 TCGA-E2-A14P-01 BREAST c.115G>C p.D39H COSMIC NP Possibly Damaging 44 TCGA-G4-6309-01 LARGE INTESTINE c.1600C>T p.R534C COSMIC PASSENGER/OTHER Probably Damaging 45 TCGA-G4-6586-01 LARGE INTESTINE c.1A>G p.M1V COSMIC NP Benign 46 TCGA-G4-6586-01 LARGE INTESTINE c.856T>C p.Y286H COSMIC NP Benign 47 YUKLAB SKIN c.1543C>T p.P515S COSMIC PASSENGER/OTHER Probably Damaging 48 YUZINO SKIN c.1621C>T p.P541S COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 12 S Phosphorylation 2 2 A Acetylation 3 200 K Acetylation 4 200 K Acetylation 5 22 C S-nitrosylation 6 227 K Ubiquitylation 7 240 K Ubiquitylation 8 280 Y Phosphorylation 9 283 Y Phosphorylation 10 286 Y Phosphorylation 11 297 Y Phosphorylation 12 304 Y Phosphorylation 13 307 Y Phosphorylation 14 333 K Ubiquitylation 15 387 K Ubiquitylation 16 479 K Ubiquitylation 17 490 K Ubiquitylation 18 60 K Ubiquitylation 19 85 K Ubiquitylation 20 95 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR PRMT5 PRMT5 PRMT5 ENSP00000216350 O14744 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt O14744 PRMT5 ENSP00000216350 PRMT5 O14744 Expression Atlas Protein Atlas OMIM IntAct PharmGKB PRMT5 ENSP00000216350 604045 O14744 PA143485403
