dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: PRMT6 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 B085 BILIARY TRACT c.299A>G p.Y100C COSMIC NP Probably Damaging 2 BN20T LIVER c.823G>C p.D275H COSMIC NP NP 3 ESO-721 OESOPHAGUS c.495C>A p.G165G COSMIC NP NP 4 ESO-859 OESOPHAGUS c.316T>C p.S106P COSMIC NP NP 5 KM12 LARGE INTESTINE c.566C>T p.A189V COSMIC PASSENGER/OTHER Probably Damaging 6 LUAD-CHTN-MAD06-00668 LUNG c.299A>G p.Y100C COSMIC NP Probably Damaging 7 PA285 PANCREAS c.384C>A p.A128A COSMIC NP NP 8 TCGA-18-3416-01 LUNG c.569G>A p.R190Q COSMIC NP NP 9 TCGA-60-2720-01 LUNG c.752C>T p.S251L COSMIC NP NP 10 TCGA-64-5775-01 LUNG c.875G>C p.R292P COSMIC NP NP 11 TCGA-69-7980-01 LUNG c.49C>T p.R17W COSMIC NP NP 12 TCGA-73-4668-01 LUNG c.602G>T p.R201L COSMIC NP Benign 13 TCGA-78-7147-01 LUNG c.531C>G p.I177M COSMIC NP NP 14 TCGA-A8-A095-01 BREAST c.253G>C p.E85Q COSMIC NP NP 15 TCGA-AA-3947-01 LARGE INTESTINE c.264A>G p.E88E COSMIC NP NP 16 TCGA-AA-3947-01 LARGE INTESTINE c.384C>A p.A128A COSMIC NP NP 17 TCGA-AA-A010-01 LARGE INTESTINE c.366C>T p.G122G COSMIC NP NP 18 TCGA-AA-A01R-01 LARGE INTESTINE c.820C>T p.Q274* COSMIC NP NP 19 TCGA-AD-6895-01 LARGE INTESTINE c.843G>A p.E281E COSMIC NP NP 20 TCGA-AP-A056-01 ENDOMETRIUM c.428A>C p.E143A COSMIC NP NP 21 TCGA-AR-A0U2-01 BREAST c.763C>T p.P255S COSMIC NP NP 22 TCGA-AX-A05Z-01 ENDOMETRIUM c.900C>A p.Y300* COSMIC NP NP 23 TCGA-AX-A0J0-01 ENDOMETRIUM c.931G>T p.D311Y COSMIC NP NP 24 TCGA-B0-5110-01 KIDNEY c.46C>A p.L16I COSMIC NP NP 25 TCGA-B5-A11H-01 ENDOMETRIUM c.441_442insT p.W149fs*>169 COSMIC NP NP 26 TCGA-BT-A20T-01 URINARY TRACT c.286G>C p.E96Q COSMIC NP NP 27 TCGA-CA-5254-01 LARGE INTESTINE c.786G>A p.A262A COSMIC NP NP 28 TCGA-CI-6622-01 LARGE INTESTINE c.21C>T p.R7R COSMIC NP NP 29 TCGA-CM-4743-01 LARGE INTESTINE c.903A>C p.K301N COSMIC NP NP 30 TCGA-D1-A15X-01 ENDOMETRIUM c.787C>T p.L263F COSMIC PASSENGER/OTHER Benign 31 TCGA-DK-A1AC-01 URINARY TRACT c.705G>A p.V235V COSMIC NP NP 32 TCGA-EJ-7115-01 PROSTATE c.513C>T p.L171L COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
