dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: PRMT8 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 134417 LUNG c.319A>C p.K107Q COSMIC PASSENGER/OTHER Benign 2 18T SKIN c.104A>G p.Q35R COSMIC PASSENGER/OTHER Benign 3 585272 LUNG c.299G>A p.R100Q COSMIC PASSENGER/OTHER Possibly Damaging 4 587284 LARGE INTESTINE c.854C>T p.T285M COSMIC PASSENGER/OTHER Possibly Damaging 5 587288 LARGE INTESTINE c.1015G>A p.V339I COSMIC PASSENGER/OTHER Possibly Damaging 6 587376 LARGE INTESTINE c.286A>G p.T96A COSMIC PASSENGER/OTHER Probably Damaging 7 587376 LARGE INTESTINE c.743C>T p.T248I COSMIC PASSENGER/OTHER Benign 8 631076 LUNG c.127G>T p.V43L COSMIC PASSENGER/OTHER Benign 9 CRC-8 LARGE INTESTINE c.127G>A p.V43M COSMIC PASSENGER/OTHER Benign 10 HCC4T LIVER c.855G>A p.T285T COSMIC NP NP 11 HCC8T LIVER c.161G>A p.S54N COSMIC PASSENGER/OTHER Benign 12 HN_62421 UPPER AERODIGESTIVE TRACT c.713G>A p.W238* COSMIC NP NP 13 HX13T LIVER c.855G>A p.T285T COSMIC NP NP 14 HX14T LIVER c.161G>A p.S54N COSMIC PASSENGER/OTHER Benign 15 ICGC_MB6 CENTRAL NERVOUS SYSTEM c.597G>A p.T199T COSMIC NP NP 16 LAU50_1 SKIN c.903C>A p.N301K COSMIC PASSENGER/OTHER Possibly Damaging 17 LAU50_2 SKIN c.903C>A p.N301K COSMIC PASSENGER/OTHER Possibly Damaging 18 LUAD-CHTN-MAD08-00104 LUNG c.753G>T p.R251R COSMIC NP NP 19 LUAD-RT-S01709 LUNG c.914A>G p.H305R COSMIC PASSENGER/OTHER Probably Damaging 20 LUAD-S01467 LUNG c.762C>A p.A254A COSMIC NP NP 21 LUAD-TLLGS LUNG c.420C>T p.I140I COSMIC NP NP 22 LUAD-YINHD LUNG c.377C>T p.S126F COSMIC PASSENGER/OTHER Probably Damaging 23 MB108C CENTRAL NERVOUS SYSTEM c.707T>C p.I236T COSMIC PASSENGER/OTHER Probably Damaging 24 PD4070a BREAST c.166C>T p.P56S COSMIC PASSENGER/OTHER Benign 25 TARGET-30-PAPREJ AUTONOMIC GANGLIA c.1180C>T p.R394C COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-05-4395-01 LUNG c.716G>T p.W239L COSMIC PASSENGER/OTHER Probably Damaging 27 TCGA-18-3411-01 LUNG c.1011G>T p.Q337H COSMIC PASSENGER/OTHER Probably Damaging 28 TCGA-24-1103-01 OVARY c.740T>G p.M247R COSMIC PASSENGER/OTHER Benign 29 TCGA-29-2427-01 OVARY c.750C>G p.I250M COSMIC PASSENGER/OTHER Benign 30 TCGA-35-4123-01 LUNG c.489C>A p.T163T COSMIC NP NP 31 TCGA-44-6144-01 LUNG c.1046G>A p.R349Q COSMIC PASSENGER/OTHER Benign 32 TCGA-44-7672-01 LUNG c.462G>A p.K154K COSMIC NP NP 33 TCGA-49-4507-01 LUNG c.172C>T p.R58W COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-50-5936-01 LUNG c.578A>G p.Y193C COSMIC PASSENGER/OTHER Probably Damaging 35 TCGA-55-7283-01 LUNG c.1066G>T p.G356W COSMIC CANCER Probably Damaging 36 TCGA-61-2111-01 OVARY c.1107C>T p.D369D COSMIC NP NP 37 TCGA-64-5779-01 LUNG c.751C>A p.R251R COSMIC NP NP 38 TCGA-66-2768-01 LUNG c.448G>C p.E150Q COSMIC PASSENGER/OTHER Benign 39 TCGA-86-6851-01 LUNG c.1146G>C p.L382L COSMIC NP NP 40 TCGA-95-7039-01 LUNG c.600G>C p.V200V COSMIC NP NP 41 TCGA-A6-3809-01 LARGE INTESTINE c.756C>T p.D252D COSMIC NP NP 42 TCGA-A6-6653-01 LARGE INTESTINE c.51G>A p.A17A COSMIC NP NP 43 TCGA-A6-6781-01 LARGE INTESTINE c.84delC p.S31fs*35 COSMIC NP NP 44 TCGA-AA-3516-01 LARGE INTESTINE c.711C>T p.H237H COSMIC NP NP 45 TCGA-AA-3663-01 LARGE INTESTINE c.356G>T p.G119V COSMIC PASSENGER/OTHER Probably Damaging 46 TCGA-AA-3666-01 LARGE INTESTINE c.1079T>C p.M360T COSMIC PASSENGER/OTHER Benign 47 TCGA-AA-3710-01 LARGE INTESTINE c.386C>A p.A129D COSMIC PASSENGER/OTHER Probably Damaging 48 TCGA-AA-3846-01 LARGE INTESTINE c.385G>A p.A129T COSMIC PASSENGER/OTHER Probably Damaging 49 TCGA-AA-3977-01 LARGE INTESTINE c.420C>T p.I140I COSMIC NP NP 50 TCGA-AG-A002-01 LARGE INTESTINE c.420C>T p.I140I COSMIC NP NP 51 TCGA-AG-A016-01 LARGE INTESTINE c.1102C>T p.R368* COSMIC NP NP 52 TCGA-AG-A02N-01 LARGE INTESTINE c.916G>A p.A306T COSMIC PASSENGER/OTHER Probably Damaging 53 TCGA-AP-A059-01 ENDOMETRIUM c.1144C>A p.L382M COSMIC PASSENGER/OTHER Possibly Damaging 54 TCGA-AX-A0J0-01 ENDOMETRIUM c.600G>T p.V200V COSMIC NP NP 55 TCGA-AX-A0J0-01 ENDOMETRIUM c.696G>T p.K232N COSMIC PASSENGER/OTHER Probably Damaging 56 TCGA-AX-A0J0-01 ENDOMETRIUM c.757G>A p.V253M COSMIC PASSENGER/OTHER Benign 57 TCGA-AZ-4315-01 LARGE INTESTINE c.1059A>C p.E353D COSMIC PASSENGER/OTHER Benign 58 TCGA-AZ-4315-01 LARGE INTESTINE c.898C>T p.R300C COSMIC PASSENGER/OTHER Probably Damaging 59 TCGA-BH-A0DI-01 BREAST c.1180C>T p.R394C COSMIC PASSENGER/OTHER Probably Damaging 60 TCGA-BP-4801-01 KIDNEY c.415G>A p.G139R COSMIC PASSENGER/OTHER Probably Damaging 61 TCGA-BS-A0UF-01 ENDOMETRIUM c.394G>A p.A132T COSMIC PASSENGER/OTHER Probably Damaging 62 TCGA-CM-6680-01 LARGE INTESTINE c.749T>C p.I250T COSMIC PASSENGER/OTHER Benign 63 TCGA-D1-A103-01 ENDOMETRIUM c.38G>T p.R13M COSMIC PASSENGER/OTHER Possibly Damaging 64 TCGA-D1-A103-01 ENDOMETRIUM c.709C>T p.H237Y COSMIC PASSENGER/OTHER Benign 65 TCGA-D1-A103-01 ENDOMETRIUM c.751C>T p.R251W COSMIC PASSENGER/OTHER Probably Damaging 66 TCGA-D1-A16B-01 ENDOMETRIUM c.1014C>T p.T338T COSMIC NP NP 67 TCGA-D5-6538-01 LARGE INTESTINE c.867G>A p.S289S COSMIC NP NP 68 TCGA-D5-6539-01 LARGE INTESTINE c.749T>C p.I250T COSMIC PASSENGER/OTHER Benign 69 TCGA-F4-6570-01 LARGE INTESTINE c.667G>A p.V223M COSMIC PASSENGER/OTHER Possibly Damaging 70 TCGA-G4-6588-01 LARGE INTESTINE c.740T>C p.M247T COSMIC PASSENGER/OTHER Benign 71 TCGA-G5-6641-01 LARGE INTESTINE c.739A>G p.M247V COSMIC PASSENGER/OTHER Benign 72 TCGA-GD-A3OP-01 URINARY TRACT c.937A>G p.I313V COSMIC PASSENGER/OTHER Benign 73 TCGA-H4-A2HQ-01 URINARY TRACT c.154C>G p.Q52E COSMIC PASSENGER/OTHER Benign 74 YULAN SKIN c.125C>T p.P42L COSMIC PASSENGER/OTHER Possibly Damaging 75 YUPAT SKIN c.1067G>A p.G356E COSMIC CANCER Probably Damaging 76 cSCCP4 SKIN c.686G>A p.R229K COSMIC PASSENGER/OTHER Benign 77 cSCCP7 SKIN c.1037T>C p.L346P COSMIC PASSENGER/OTHER Probably Damaging 78 pfg016T STOMACH c.597G>A p.T199T COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 122 T Phosphorylation 2 126 S Phosphorylation 3 2 G Myristoylation 4 58 R Methylation 5 58 R Methylation 6 73 R Methylation 7 73 R Methylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR PRMT8 PRMT8 PRMT8 ENSP00000372067 Q9NR22 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9NR22 PRMT8 ENSP00000372067 PRMT8 Q9NR22 Expression Atlas Protein Atlas OMIM IntAct PharmGKB PRMT8 ENSP00000372067 610086 Q9NR22 PA134903406
