dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: PRMT8 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 134417 LUNG c.319A>C p.K107Q COSMIC PASSENGER/OTHER Benign 2 18T SKIN c.104A>G p.Q35R COSMIC PASSENGER/OTHER Benign 3 585272 LUNG c.299G>A p.R100Q COSMIC PASSENGER/OTHER Possibly Damaging 4 587284 LARGE INTESTINE c.854C>T p.T285M COSMIC PASSENGER/OTHER Possibly Damaging 5 587288 LARGE INTESTINE c.1015G>A p.V339I COSMIC PASSENGER/OTHER Possibly Damaging 6 587376 LARGE INTESTINE c.286A>G p.T96A COSMIC PASSENGER/OTHER Probably Damaging 7 587376 LARGE INTESTINE c.743C>T p.T248I COSMIC PASSENGER/OTHER Benign 8 631076 LUNG c.127G>T p.V43L COSMIC PASSENGER/OTHER Benign 9 CRC-8 LARGE INTESTINE c.127G>A p.V43M COSMIC PASSENGER/OTHER Benign 10 HCC4T LIVER c.855G>A p.T285T COSMIC NP NP 11 HCC8T LIVER c.161G>A p.S54N COSMIC PASSENGER/OTHER Benign 12 HN_62421 UPPER AERODIGESTIVE TRACT c.713G>A p.W238* COSMIC NP NP 13 HX13T LIVER c.855G>A p.T285T COSMIC NP NP 14 HX14T LIVER c.161G>A p.S54N COSMIC PASSENGER/OTHER Benign 15 ICGC_MB6 CENTRAL NERVOUS SYSTEM c.597G>A p.T199T COSMIC NP NP 16 LAU50_1 SKIN c.903C>A p.N301K COSMIC PASSENGER/OTHER Possibly Damaging 17 LAU50_2 SKIN c.903C>A p.N301K COSMIC PASSENGER/OTHER Possibly Damaging 18 LUAD-CHTN-MAD08-00104 LUNG c.753G>T p.R251R COSMIC NP NP 19 LUAD-RT-S01709 LUNG c.914A>G p.H305R COSMIC PASSENGER/OTHER Probably Damaging 20 LUAD-S01467 LUNG c.762C>A p.A254A COSMIC NP NP 21 LUAD-TLLGS LUNG c.420C>T p.I140I COSMIC NP NP 22 LUAD-YINHD LUNG c.377C>T p.S126F COSMIC PASSENGER/OTHER Probably Damaging 23 MB108C CENTRAL NERVOUS SYSTEM c.707T>C p.I236T COSMIC PASSENGER/OTHER Probably Damaging 24 PD4070a BREAST c.166C>T p.P56S COSMIC PASSENGER/OTHER Benign 25 TARGET-30-PAPREJ AUTONOMIC GANGLIA c.1180C>T p.R394C COSMIC PASSENGER/OTHER Probably Damaging 26 TCGA-05-4395-01 LUNG c.716G>T p.W239L COSMIC PASSENGER/OTHER Probably Damaging 27 TCGA-18-3411-01 LUNG c.1011G>T p.Q337H COSMIC PASSENGER/OTHER Probably Damaging 28 TCGA-24-1103-01 OVARY c.740T>G p.M247R COSMIC PASSENGER/OTHER Benign 29 TCGA-29-2427-01 OVARY c.750C>G p.I250M COSMIC PASSENGER/OTHER Benign 30 TCGA-35-4123-01 LUNG c.489C>A p.T163T COSMIC NP NP 31 TCGA-44-6144-01 LUNG c.1046G>A p.R349Q COSMIC PASSENGER/OTHER Benign 32 TCGA-44-7672-01 LUNG c.462G>A p.K154K COSMIC NP NP 33 TCGA-49-4507-01 LUNG c.172C>T p.R58W COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-50-5936-01 LUNG c.578A>G p.Y193C COSMIC PASSENGER/OTHER Probably Damaging 35 TCGA-55-7283-01 LUNG c.1066G>T p.G356W COSMIC CANCER Probably Damaging 36 TCGA-61-2111-01 OVARY c.1107C>T p.D369D COSMIC NP NP 37 TCGA-64-5779-01 LUNG c.751C>A p.R251R COSMIC NP NP 38 TCGA-66-2768-01 LUNG c.448G>C p.E150Q COSMIC PASSENGER/OTHER Benign 39 TCGA-86-6851-01 LUNG c.1146G>C p.L382L COSMIC NP NP 40 TCGA-95-7039-01 LUNG c.600G>C p.V200V COSMIC NP NP 41 TCGA-A6-3809-01 LARGE INTESTINE c.756C>T p.D252D COSMIC NP NP 42 TCGA-A6-6653-01 LARGE INTESTINE c.51G>A p.A17A COSMIC NP NP 43 TCGA-A6-6781-01 LARGE INTESTINE c.84delC p.S31fs*35 COSMIC NP NP 44 TCGA-AA-3516-01 LARGE INTESTINE c.711C>T p.H237H COSMIC NP NP 45 TCGA-AA-3663-01 LARGE INTESTINE c.356G>T p.G119V COSMIC PASSENGER/OTHER Probably Damaging 46 TCGA-AA-3666-01 LARGE INTESTINE c.1079T>C p.M360T COSMIC PASSENGER/OTHER Benign 47 TCGA-AA-3710-01 LARGE INTESTINE c.386C>A p.A129D COSMIC PASSENGER/OTHER Probably Damaging 48 TCGA-AA-3846-01 LARGE INTESTINE c.385G>A p.A129T COSMIC PASSENGER/OTHER Probably Damaging 49 TCGA-AA-3977-01 LARGE INTESTINE c.420C>T p.I140I COSMIC NP NP 50 TCGA-AG-A002-01 LARGE INTESTINE c.420C>T p.I140I COSMIC NP NP 51 TCGA-AG-A016-01 LARGE INTESTINE c.1102C>T p.R368* COSMIC NP NP 52 TCGA-AG-A02N-01 LARGE INTESTINE c.916G>A p.A306T COSMIC PASSENGER/OTHER Probably Damaging 53 TCGA-AP-A059-01 ENDOMETRIUM c.1144C>A p.L382M COSMIC PASSENGER/OTHER Possibly Damaging 54 TCGA-AX-A0J0-01 ENDOMETRIUM c.600G>T p.V200V COSMIC NP NP 55 TCGA-AX-A0J0-01 ENDOMETRIUM c.696G>T p.K232N COSMIC PASSENGER/OTHER Probably Damaging 56 TCGA-AX-A0J0-01 ENDOMETRIUM c.757G>A p.V253M COSMIC PASSENGER/OTHER Benign 57 TCGA-AZ-4315-01 LARGE INTESTINE c.1059A>C p.E353D COSMIC PASSENGER/OTHER Benign 58 TCGA-AZ-4315-01 LARGE INTESTINE c.898C>T p.R300C COSMIC PASSENGER/OTHER Probably Damaging 59 TCGA-BH-A0DI-01 BREAST c.1180C>T p.R394C COSMIC PASSENGER/OTHER Probably Damaging 60 TCGA-BP-4801-01 KIDNEY c.415G>A p.G139R COSMIC PASSENGER/OTHER Probably Damaging 61 TCGA-BS-A0UF-01 ENDOMETRIUM c.394G>A p.A132T COSMIC PASSENGER/OTHER Probably Damaging 62 TCGA-CM-6680-01 LARGE INTESTINE c.749T>C p.I250T COSMIC PASSENGER/OTHER Benign 63 TCGA-D1-A103-01 ENDOMETRIUM c.38G>T p.R13M COSMIC PASSENGER/OTHER Possibly Damaging 64 TCGA-D1-A103-01 ENDOMETRIUM c.709C>T p.H237Y COSMIC PASSENGER/OTHER Benign 65 TCGA-D1-A103-01 ENDOMETRIUM c.751C>T p.R251W COSMIC PASSENGER/OTHER Probably Damaging 66 TCGA-D1-A16B-01 ENDOMETRIUM c.1014C>T p.T338T COSMIC NP NP 67 TCGA-D5-6538-01 LARGE INTESTINE c.867G>A p.S289S COSMIC NP NP 68 TCGA-D5-6539-01 LARGE INTESTINE c.749T>C p.I250T COSMIC PASSENGER/OTHER Benign 69 TCGA-F4-6570-01 LARGE INTESTINE c.667G>A p.V223M COSMIC PASSENGER/OTHER Possibly Damaging 70 TCGA-G4-6588-01 LARGE INTESTINE c.740T>C p.M247T COSMIC PASSENGER/OTHER Benign 71 TCGA-G5-6641-01 LARGE INTESTINE c.739A>G p.M247V COSMIC PASSENGER/OTHER Benign 72 TCGA-GD-A3OP-01 URINARY TRACT c.937A>G p.I313V COSMIC PASSENGER/OTHER Benign 73 TCGA-H4-A2HQ-01 URINARY TRACT c.154C>G p.Q52E COSMIC PASSENGER/OTHER Benign 74 YULAN SKIN c.125C>T p.P42L COSMIC PASSENGER/OTHER Possibly Damaging 75 YUPAT SKIN c.1067G>A p.G356E COSMIC CANCER Probably Damaging 76 cSCCP4 SKIN c.686G>A p.R229K COSMIC PASSENGER/OTHER Benign 77 cSCCP7 SKIN c.1037T>C p.L346P COSMIC PASSENGER/OTHER Probably Damaging 78 pfg016T STOMACH c.597G>A p.T199T COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score. -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
