dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: RING1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 107T THYROID c.293G>A p.R98Q COSMIC PASSENGER/OTHER Probably Damaging 2 ESO-075 OESOPHAGUS c.263G>T p.R88L COSMIC PASSENGER/OTHER Probably Damaging 3 H2171 LUNG c.512G>T p.G171V COSMIC PASSENGER/OTHER Probably Damaging 4 ME011T SKIN c.641G>A p.G214E COSMIC CANCER Benign 5 MZ7-mel SKIN c.933G>A p.Q311Q COSMIC NP NP 6 NB-1613 AUTONOMIC GANGLIA c.1166G>A p.W389* COSMIC NP NP 7 P03-1334 PROSTATE c.777T>G p.G259G COSMIC NP NP 8 PR-00-1165 PROSTATE c.313G>A p.A105T COSMIC PASSENGER/OTHER Possibly Damaging 9 RK126_C01 LIVER c.1169A>C p.K390T COSMIC PASSENGER/OTHER Probably Damaging 10 TCGA-04-1347-01 OVARY c.329T>G p.I110S COSMIC PASSENGER/OTHER Probably Damaging 11 TCGA-13-0751-01 OVARY c.593C>T p.P198L COSMIC PASSENGER/OTHER Possibly Damaging 12 TCGA-39-5031-01 LUNG c.795G>C p.V265V COSMIC NP NP 13 TCGA-55-7570-01 LUNG c.969C>T p.A323A COSMIC NP NP 14 TCGA-66-2782-01 LUNG c.899C>G p.A300G COSMIC CANCER Probably Damaging 15 TCGA-95-7039-01 LUNG c.775G>T p.G259C COSMIC PASSENGER/OTHER Probably Damaging 16 TCGA-A6-6141-01 LARGE INTESTINE c.221T>C p.V74A COSMIC PASSENGER/OTHER Possibly Damaging 17 TCGA-AA-3713-01 LARGE INTESTINE c.735delC p.P247fs*38 COSMIC NP NP 18 TCGA-AA-3984-01 LARGE INTESTINE c.1112C>T p.A371V COSMIC PASSENGER/OTHER Possibly Damaging 19 TCGA-AP-A05A-01 ENDOMETRIUM c.501A>C p.T167T COSMIC NP NP 20 TCGA-AP-A0LP-01 ENDOMETRIUM c.238G>T p.G80W COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-AX-A0J1-01 ENDOMETRIUM c.898G>A p.A300T COSMIC CANCER Probably Damaging 22 TCGA-AZ-4315-01 LARGE INTESTINE c.53T>G p.L18R COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-BG-A0M0-01 ENDOMETRIUM c.284G>A p.R95Q COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-BH-A0DQ-01 BREAST c.1004A>G p.E335G COSMIC PASSENGER/OTHER Benign 25 TCGA-CK-6746-01 LARGE INTESTINE c.511delG p.E173fs*14 COSMIC NP NP 26 TCGA-CM-4743-01 LARGE INTESTINE c.511delG p.E173fs*14 COSMIC NP NP 27 TCGA-CM-6171-01 LARGE INTESTINE c.511delG p.E173fs*14 COSMIC NP NP 28 TCGA-CM-6171-01 LARGE INTESTINE c.735delC p.P247fs*38 COSMIC NP NP 29 TCGA-D1-A103-01 ENDOMETRIUM c.1017C>T p.A339A COSMIC NP NP 30 TCGA-D1-A174-01 ENDOMETRIUM c.1055G>A p.S352N COSMIC PASSENGER/OTHER Benign 31 TCGA-D1-A176-01 ENDOMETRIUM c.436C>T p.R146C COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-D1-A17Q-01 ENDOMETRIUM c.234G>A p.R78R COSMIC NP NP 33 TCGA-D5-6930-01 LARGE INTESTINE c.646delG p.G217fs*68 COSMIC NP NP 34 TCGA-DC-5337-01 LARGE INTESTINE c.368G>A p.R123Q COSMIC PASSENGER/OTHER Possibly Damaging 35 TCGA-DM-A1HA-01 LARGE INTESTINE c.743G>T p.S248I COSMIC PASSENGER/OTHER Possibly Damaging 36 TCGA-G4-6586-01 LARGE INTESTINE c.1121C>T p.T374M COSMIC PASSENGER/OTHER Probably Damaging 37 cSCCP4 SKIN c.301C>T p.P101S COSMIC PASSENGER/OTHER Benign 38 cSCCP4 SKIN c.406G>A p.A136T COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
