dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: RUVBL1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 CP66-MEL SKIN c.306C>T p.Y102Y COSMIC NP NP 2 HN_62421 UPPER AERODIGESTIVE TRACT c.948C>A p.H316Q COSMIC PASSENGER/OTHER Benign 3 LUAD-5V8LT LUNG c.1099A>T p.T367S COSMIC PASSENGER/OTHER Benign 4 LUAD-S01315 LUNG c.405C>T p.V135V COSMIC NP NP 5 LUAD-S01315 LUNG c.556G>T p.E186* COSMIC NP NP 6 ME050T SKIN c.1361A>T p.Y454F COSMIC PASSENGER/OTHER Benign 7 T155 ENDOMETRIUM c.634G>T p.E212* COSMIC NP NP 8 TCGA-33-6737-01 LUNG c.1026G>T p.E342D COSMIC PASSENGER/OTHER Benign 9 TCGA-34-5239-01 LUNG c.51C>T p.S17S COSMIC NP NP 10 TCGA-43-5668-01 LUNG c.368G>T p.R123L COSMIC PASSENGER/OTHER Possibly Damaging 11 TCGA-44-2656-01 LUNG c.141G>T p.E47D COSMIC PASSENGER/OTHER Probably Damaging 12 TCGA-53-7624-01 LUNG c.114G>A p.G38G COSMIC NP NP 13 TCGA-55-7574-01 LUNG c.813C>G p.I271M COSMIC PASSENGER/OTHER Possibly Damaging 14 TCGA-66-2792-01 LUNG c.532G>T p.E178* COSMIC NP NP 15 TCGA-78-7162-01 LUNG c.979G>A p.V327I COSMIC PASSENGER/OTHER Benign 16 TCGA-78-7166-01 LUNG c.476T>G p.I159R COSMIC PASSENGER/OTHER Probably Damaging 17 TCGA-78-7167-01 LUNG c.72G>A p.L24L COSMIC NP NP 18 TCGA-A6-2672-01 LARGE INTESTINE c.490G>A p.A164T COSMIC PASSENGER/OTHER Benign 19 TCGA-AA-3560-01 LARGE INTESTINE c.1249G>C p.A417P COSMIC PASSENGER/OTHER Possibly Damaging 20 TCGA-AA-3715-01 LARGE INTESTINE c.349C>T p.R117C COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-AA-3864-01 LARGE INTESTINE c.349C>T p.R117C COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-AA-A00N-01 LARGE INTESTINE c.1291G>A p.E431K COSMIC PASSENGER/OTHER Benign 23 TCGA-AA-A022-01 LARGE INTESTINE c.551G>A p.R184Q COSMIC PASSENGER/OTHER Benign 24 TCGA-AG-3598-01 LARGE INTESTINE c.746G>A p.R249Q COSMIC PASSENGER/OTHER Benign 25 TCGA-AG-A002-01 LARGE INTESTINE c.1122C>T p.I374I COSMIC NP NP 26 TCGA-AG-A002-01 LARGE INTESTINE c.1291G>A p.E431K COSMIC PASSENGER/OTHER Benign 27 TCGA-B5-A11E-01 ENDOMETRIUM c.1107G>T p.Q369H COSMIC PASSENGER/OTHER Benign 28 TCGA-B8-4151-01 KIDNEY c.794A>G p.K265R COSMIC PASSENGER/OTHER Benign 29 TCGA-BH-A0DX-01 BREAST c.928G>A p.E310K COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-BS-A0UV-01 ENDOMETRIUM c.697G>T p.E233* COSMIC NP NP 31 TCGA-BT-A20J-01 URINARY TRACT c.241C>T p.L81L COSMIC NP NP 32 TCGA-CM-4746-01 LARGE INTESTINE c.743C>T p.A248V COSMIC PASSENGER/OTHER Possibly Damaging 33 TCGA-D1-A165-01 ENDOMETRIUM c.744G>A p.A248A COSMIC NP NP 34 TCGA-DK-A3IS-01 URINARY TRACT c.110C>T p.S37L COSMIC PASSENGER/OTHER Benign 35 TCGA-E2-A155-01 BREAST c.1272C>T p.S424S COSMIC NP NP 36 TCGA-G2-A3IE-01 URINARY TRACT c.1235C>T p.P412L COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
