dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: RUVBL2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 HN_63021 UPPER AERODIGESTIVE TRACT c.1235G>A p.G412D COSMIC NP NP 2 TCGA-AA-3864-01 LARGE INTESTINE c.871C>T p.R291W COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 164 K Ubiquitylation 2 184 K Ubiquitylation 3 186 K Ubiquitylation 4 197 K Ubiquitylation 5 2 A Acetylation 6 215 Y Phosphorylation 7 220 S Phosphorylation 8 220 S Phosphorylation 9 234 K Ubiquitylation 10 26 S Phosphorylation 11 262 S Phosphorylation 12 265 T Phosphorylation 13 269 K Ubiquitylation 14 279 K Ubiquitylation 15 3 T Phosphorylation 16 338 T Phosphorylation 17 339 S Phosphorylation 18 340 Y Phosphorylation 19 365 K Ubiquitylation 20 368 K Ubiquitylation 21 417 K Ubiquitylation 22 427 K Ubiquitylation 23 430 Y Phosphorylation 24 431 S Phosphorylation 25 444 K Ubiquitylation 26 456 K Sumoylation 27 456 K Ubiquitylation 28 81 T Phosphorylation 29 9 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR RUVBL2 RUVBL2 RUVBL2 ENSP00000473172 Q9Y230 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9Y230 RUVBL2 ENSP00000473172 RUVBL2 Q9Y230 Expression Atlas Protein Atlas OMIM IntAct PharmGKB RUVBL2 ENSP00000473172 604788 Q9Y230 PA34888
