dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SETD4 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587222 LARGE INTESTINE c.269G>A p.R90Q COSMIC PASSENGER/OTHER Benign 2 ESO-131 OESOPHAGUS c.890A>G p.Y297C COSMIC PASSENGER/OTHER Probably Damaging 3 Mx32 LARGE INTESTINE c.1259A>G p.E420G COSMIC PASSENGER/OTHER Probably Damaging 4 N492T AUTONOMIC GANGLIA c.721G>T p.V241F COSMIC PASSENGER/OTHER Probably Damaging 5 PD7301a BONE c.487A>G p.R163G COSMIC PASSENGER/OTHER Possibly Damaging 6 PR-09-5700 PROSTATE c.1243G>T p.E415* COSMIC NP NP 7 TCGA-04-1530-01 OVARY c.269G>A p.R90Q COSMIC PASSENGER/OTHER Benign 8 TCGA-18-3415-01 LUNG c.1255A>T p.T419S COSMIC PASSENGER/OTHER Benign 9 TCGA-22-4613-01 LUNG c.53G>C p.G18A COSMIC PASSENGER/OTHER Benign 10 TCGA-39-5024-01 LUNG c.373C>G p.L125V COSMIC PASSENGER/OTHER Benign 11 TCGA-44-2657-01 LUNG c.79G>T p.E27* COSMIC NP NP 12 TCGA-49-4486-01 LUNG c.210G>C p.E70D COSMIC PASSENGER/OTHER Possibly Damaging 13 TCGA-A5-A0VP-01 ENDOMETRIUM c.625G>A p.V209M COSMIC PASSENGER/OTHER Probably Damaging 14 TCGA-A6-6142-01 LARGE INTESTINE c.772A>G p.T258A COSMIC PASSENGER/OTHER Benign 15 TCGA-A6-6780-01 LARGE INTESTINE c.610G>A p.V204I COSMIC PASSENGER/OTHER Possibly Damaging 16 TCGA-AA-3510-01 LARGE INTESTINE c.1288G>A p.E430K COSMIC PASSENGER/OTHER Benign 17 TCGA-AA-3552-01 LARGE INTESTINE c.30G>A p.R10R COSMIC NP NP 18 TCGA-AA-3984-01 LARGE INTESTINE c.696G>A p.L232L COSMIC NP NP 19 TCGA-AG-A002-01 LARGE INTESTINE c.269G>A p.R90Q COSMIC PASSENGER/OTHER Benign 20 TCGA-AP-A056-01 ENDOMETRIUM c.763G>A p.E255K COSMIC PASSENGER/OTHER Probably Damaging 21 TCGA-AX-A05Z-01 ENDOMETRIUM c.629A>G p.Y210C COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-AZ-6598-01 LARGE INTESTINE c.172A>G p.T58A COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-B5-A0JY-01 ENDOMETRIUM c.763G>A p.E255K COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-B5-A0JY-01 ENDOMETRIUM c.997G>A p.G333R COSMIC PASSENGER/OTHER Probably Damaging 25 TCGA-B5-A11E-01 ENDOMETRIUM c.6G>A p.Q2Q COSMIC NP NP 26 TCGA-B5-A11E-01 ENDOMETRIUM c.739T>C p.F247L COSMIC PASSENGER/OTHER Probably Damaging 27 TCGA-BP-5168-01 KIDNEY c.552T>A p.F184L COSMIC PASSENGER/OTHER Benign 28 TCGA-BS-A0UF-01 ENDOMETRIUM c.148T>C p.L50L COSMIC NP NP 29 TCGA-BS-A0UV-01 ENDOMETRIUM c.269G>A p.R90Q COSMIC PASSENGER/OTHER Benign 30 TCGA-CZ-4866-01 KIDNEY c.419C>T p.P140L COSMIC PASSENGER/OTHER Probably Damaging 31 TCGA-D1-A17Q-01 ENDOMETRIUM c.41G>A p.R14Q COSMIC PASSENGER/OTHER Possibly Damaging 32 TCGA-D5-6539-01 LARGE INTESTINE c.1259A>T p.E420V COSMIC PASSENGER/OTHER Probably Damaging 33 TCGA-DK-A1A6-01 URINARY TRACT c.94G>C p.E32Q COSMIC PASSENGER/OTHER Benign 34 TCGA-DK-A3IK-01 URINARY TRACT c.1269G>C p.K423N COSMIC PASSENGER/OTHER Benign 35 YUKIL SKIN c.251_252CC>TT p.T84I COSMIC PASSENGER/OTHER Probably Damaging 36 YUVAIL SKIN c.143C>T p.S48L COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
-
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
-
Post Translational Modifications (+)
S. No. Position Amino acid Type 1 127 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SETD4 SETD4 SETD4 ENSP00000329189 Q9NVD3 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9NVD3 SETD4 ENSP00000329189 SETD4 Q9NVD3 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SETD4 ENSP00000329189 NA Q9NVD3 PA25814
