dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SETD5 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587220 LARGE INTESTINE c.1465A>G p.T489A COSMIC NP NP 2 587224 LARGE INTESTINE c.1042C>T p.R348W COSMIC PASSENGER/OTHER Probably Damaging 3 587278 LARGE INTESTINE c.746C>A p.A249D COSMIC NP NP 4 587282 LARGE INTESTINE c.3095T>G p.F1032C COSMIC NP NP 5 587376 LARGE INTESTINE c.1186G>T p.E396* COSMIC NP NP 6 587376 LARGE INTESTINE c.2035T>C p.F679L COSMIC NP NP 7 587376 LARGE INTESTINE c.948A>C p.Q316H COSMIC NP Probably Damaging 8 BN06T LIVER c.2800G>A p.G934S COSMIC NP NP 9 BN36T LIVER c.3288G>C p.K1096N COSMIC NP NP 10 ESO-1096 OESOPHAGUS c.754A>C p.I252L COSMIC NP NP 11 ESO-111 OESOPHAGUS c.1684A>T p.T562S COSMIC NP NP 12 ESO-859 OESOPHAGUS c.3041C>T p.A1014V COSMIC NP NP 13 H1155 LUNG c.1300C>T p.R434W COSMIC NP NP 14 H2122 LUNG c.2633C>G p.A878G COSMIC NP NP 15 HCC101T LIVER c.26T>C p.L9P COSMIC NP NP 16 HCC63T LIVER c.84G>A p.W28* COSMIC NP NP 17 HCC77T LIVER c.3115A>G p.M1039V COSMIC NP NP 18 HN_63021 UPPER AERODIGESTIVE TRACT c.3432G>A p.L1144L COSMIC NP NP 19 LC_C6 LUNG c.172C>G p.P58A COSMIC NP NP 20 LUAD-CHTN-MAD06-00678 LUNG c.3867G>T p.R1289R COSMIC NP NP 21 LUAD_E01166 LUNG c.3068G>C p.R1023P COSMIC NP NP 22 ME049T NS c.487A>G p.N163D COSMIC NP NP 23 OLID10 CENTRAL NERVOUS SYSTEM c.787C>T p.R263* COSMIC NP NP 24 PD3995a BREAST c.1559G>T p.R520L COSMIC NP NP 25 PD4123a BREAST c.2594_2617del24 p.D866_R873delDGHQTLVR COSMIC NP NP 26 PD4202a NS c.3292G>C p.E1098Q COSMIC NP NP 27 PR-09-5094 PROSTATE c.910T>G p.C304G COSMIC NP NP 28 TCGA-13-0791-01 OVARY c.2880G>A p.Q960Q COSMIC NP NP 29 TCGA-18-3409-01 LUNG c.3605C>T p.S1202F COSMIC NP NP 30 TCGA-21-1071-01 LUNG c.2398G>A p.A800T COSMIC NP NP 31 TCGA-22-4613-01 LUNG c.457G>A p.D153N COSMIC NP NP 32 TCGA-25-2392-01 OVARY c.3687T>C p.S1229S COSMIC NP NP 33 TCGA-37-4135-01 LUNG c.3977A>T p.Q1326L COSMIC NP NP 34 TCGA-37-5819-01 LUNG c.2009G>T p.R670L COSMIC NP NP 35 TCGA-39-5016-01 LUNG c.1943C>T p.P648L COSMIC NP Benign 36 TCGA-44-7667-01 LUNG c.3486C>T p.S1162S COSMIC NP NP 37 TCGA-55-6642-01 LUNG c.1299G>A p.R433R COSMIC NP NP 38 TCGA-55-6970-01 LUNG c.59G>T p.G20V COSMIC NP NP 39 TCGA-55-6978-01 LUNG c.68G>C p.S23T COSMIC PASSENGER/OTHER Probably Damaging 40 TCGA-59-2352-01 OVARY c.2778A>G p.G926G COSMIC NP NP 41 TCGA-86-6851-01 LUNG c.3129G>T p.E1043D COSMIC NP NP 42 TCGA-95-7043-01 LUNG c.4024G>C p.G1342R COSMIC NP NP 43 TCGA-A6-3809-01 LARGE INTESTINE c.606G>A p.E202E COSMIC NP NP 44 TCGA-A6-6781-01 LARGE INTESTINE c.3559C>A p.P1187T COSMIC NP NP 45 TCGA-AA-3662-01 LARGE INTESTINE c.3685T>C p.S1229P COSMIC NP NP 46 TCGA-AA-3710-01 LARGE INTESTINE c.2404C>T p.R802C COSMIC NP NP 47 TCGA-AA-3821-01 LARGE INTESTINE c.331C>T p.R111W COSMIC NP NP 48 TCGA-AA-3855-01 LARGE INTESTINE c.2639G>A p.R880Q COSMIC NP NP 49 TCGA-AA-3975-01 LARGE INTESTINE c.1011T>G p.I337M COSMIC NP NP 50 TCGA-AA-A01D-01 LARGE INTESTINE c.756C>T p.I252I COSMIC NP NP 51 TCGA-AA-A022-01 LARGE INTESTINE c.3803delC p.T1268fs*4 COSMIC NP NP 52 TCGA-AD-5900-01 LARGE INTESTINE c.1548G>A p.R516R COSMIC NP NP 53 TCGA-AG-3893-01 LARGE INTESTINE c.3422A>G p.Y1141C COSMIC NP NP 54 TCGA-AG-A002-01 LARGE INTESTINE c.2096C>A p.S699* COSMIC NP NP 55 TCGA-AG-A002-01 LARGE INTESTINE c.3092A>C p.K1031T COSMIC NP NP 56 TCGA-AG-A002-01 LARGE INTESTINE c.500T>G p.I167S COSMIC NP NP 57 TCGA-AO-A0J5-01 BREAST c.785T>A p.V262E COSMIC NP NP 58 TCGA-AP-A051-01 ENDOMETRIUM c.1360A>G p.T454A COSMIC NP NP 59 TCGA-AP-A056-01 ENDOMETRIUM c.2054G>A p.R685H COSMIC NP NP 60 TCGA-AP-A056-01 ENDOMETRIUM c.227A>G p.K76R COSMIC NP NP 61 TCGA-AP-A059-01 ENDOMETRIUM c.1072G>A p.E358K COSMIC NP NP 62 TCGA-AP-A059-01 ENDOMETRIUM c.3926C>T p.A1309V COSMIC NP NP 63 TCGA-AP-A0LT-01 ENDOMETRIUM c.786G>A p.V262V COSMIC NP NP 64 TCGA-AR-A1AV-01 BREAST c.1904C>A p.A635E COSMIC NP NP 65 TCGA-AY-6197-01 LARGE INTESTINE c.443A>G p.K148R COSMIC NP NP 66 TCGA-AY-6386-01 LARGE INTESTINE c.3865C>T p.R1289W COSMIC NP NP 67 TCGA-AZ-4315-01 LARGE INTESTINE c.1040G>A p.R347Q COSMIC NP NP 68 TCGA-AZ-4315-01 LARGE INTESTINE c.1503A>C p.E501D COSMIC PASSENGER/OTHER Benign 69 TCGA-AZ-4315-01 LARGE INTESTINE c.294G>A p.Q98Q COSMIC NP NP 70 TCGA-B5-A0JY-01 ENDOMETRIUM c.217A>C p.K73Q COSMIC NP NP 71 TCGA-B5-A0JY-01 ENDOMETRIUM c.3363G>A p.E1121E COSMIC NP NP 72 TCGA-B5-A11E-01 ENDOMETRIUM c.2192G>A p.S731N COSMIC NP NP 73 TCGA-BG-A0LX-01 ENDOMETRIUM c.3891G>A p.G1297G COSMIC NP NP 74 TCGA-BH-A0W7-01 BREAST c.3686C>G p.S1229C COSMIC NP NP 75 TCGA-BH-A1FL-01 BREAST c.2083A>G p.M695V COSMIC NP NP 76 TCGA-BS-A0TE-01 ENDOMETRIUM c.1094A>G p.D365G COSMIC NP NP 77 TCGA-BS-A0UM-01 ENDOMETRIUM c.2558G>T p.G853V COSMIC NP NP 78 TCGA-BS-A0UV-01 ENDOMETRIUM c.1028G>A p.R343H COSMIC NP NP 79 TCGA-BS-A0UV-01 ENDOMETRIUM c.294G>T p.Q98H COSMIC NP NP 80 TCGA-BS-A0UV-01 ENDOMETRIUM c.3063A>G p.S1021S COSMIC NP NP 81 TCGA-BS-A0UV-01 ENDOMETRIUM c.610C>T p.R204C COSMIC NP NP 82 TCGA-BT-A20U-01 URINARY TRACT c.628C>T p.R210* COSMIC NP NP 83 TCGA-CA-6717-01 LARGE INTESTINE c.2173G>T p.D725Y COSMIC NP NP 84 TCGA-CA-6717-01 LARGE INTESTINE c.651G>T p.G217G COSMIC NP NP 85 TCGA-CH-5761-01 PROSTATE c.304G>A p.E102K COSMIC NP NP 86 TCGA-CH-5761-01 PROSTATE c.333G>A p.R111R COSMIC NP NP 87 TCGA-CH-5761-01 PROSTATE c.388G>A p.D130N COSMIC NP NP 88 TCGA-CH-5761-01 PROSTATE c.396G>C p.Q132H COSMIC NP NP 89 TCGA-CH-5761-01 PROSTATE c.440G>A p.G147D COSMIC NP NP 90 TCGA-CH-5769-01 PROSTATE c.2350C>T p.R784* COSMIC NP NP 91 TCGA-CK-6746-01 LARGE INTESTINE c.3088delA p.K1031fs*15 COSMIC NP NP 92 TCGA-CW-6090-01 KIDNEY c.2104C>A p.P702T COSMIC NP NP 93 TCGA-CZ-5462-01 KIDNEY c.732T>C p.T244T COSMIC NP NP 94 TCGA-D1-A101-01 ENDOMETRIUM c.834G>A p.V278V COSMIC NP NP 95 TCGA-D1-A103-01 ENDOMETRIUM c.1434C>A p.I478I COSMIC NP NP 96 TCGA-D1-A167-01 ENDOMETRIUM c.2313C>A p.A771A COSMIC NP NP 97 TCGA-D1-A16J-01 ENDOMETRIUM c.764C>A p.S255* COSMIC NP NP 98 TCGA-D1-A17Q-01 ENDOMETRIUM c.2351G>A p.R784Q COSMIC NP NP 99 TCGA-DK-A3IQ-01 URINARY TRACT c.304G>A p.E102K COSMIC NP NP 100 TCGA-EY-A212-01 ENDOMETRIUM c.2970_2971delCT p.S991fs*16 COSMIC NP NP 101 TCGA-F4-6570-01 LARGE INTESTINE c.787C>T p.R263* COSMIC NP NP 102 TCGA-G4-6310-01 LARGE INTESTINE c.2778A>G p.G926G COSMIC NP NP 103 TCGA-G4-6628-01 LARGE INTESTINE c.2927G>A p.R976Q COSMIC NP NP 104 TCGA-GD-A2C5-01 URINARY TRACT c.3609C>A p.S1203R COSMIC PASSENGER/OTHER Benign 105 WA33 PROSTATE c.3831T>C p.P1277P COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 1020 S Phosphorylation 2 1020 S Phosphorylation 3 1026 S Phosphorylation 4 1027 S Phosphorylation 5 1094 S Phosphorylation 6 1096 S Phosphorylation 7 1103 S Phosphorylation 8 1104 S Phosphorylation 9 1106 S Phosphorylation 10 1108 S Phosphorylation 11 1118 S Phosphorylation 12 1119 S Phosphorylation 13 1124 S Phosphorylation 14 1125 S Phosphorylation 15 1125 S Phosphorylation 16 1198 S Phosphorylation 17 1198 S Phosphorylation 18 1203 S Phosphorylation 19 1269 S Phosphorylation 20 1269 S Phosphorylation 21 1299 Y Phosphorylation 22 1301 S Phosphorylation 23 474 T Phosphorylation 24 72 S Phosphorylation 25 72 S Phosphorylation 26 829 S Phosphorylation 27 838 Y Phosphorylation 28 852 S Phosphorylation 29 855 T Phosphorylation 30 890 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SETD5 SETD5 SETD5 ENSP00000302028 Q9C0A6 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9C0A6 SETD5 ENSP00000302028 SETD5 Q9C0A6 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SETD5 ENSP00000302028 615743 Q9C0A6 PA143485613
