dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SETD8 |
| Expand All | Collapse All |
-
Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587220 LARGE INTESTINE c.943G>A p.V315I COSMIC NP NP 2 587376 LARGE INTESTINE c.219G>T p.E73D COSMIC NP NP 3 ESO-1748 OESOPHAGUS c.963C>A p.I321I COSMIC NP NP 4 H1155 LUNG c.677A>C p.K226T COSMIC NP NP 5 HCC123T LIVER c.874C>A p.R292S COSMIC NP NP 6 ICGC_MB16 CENTRAL NERVOUS SYSTEM c.267C>T p.A89A COSMIC NP NP 7 LUAD-RT-S01721 LUNG c.609G>A p.R203R COSMIC NP NP 8 MOLT-4 HAEMATOPOIETIC AND LYMPHOID TISSUE c.524C>T p.T175M COSMIC NP NP 9 SWE-47 PROSTATE c.267C>T p.A89A COSMIC NP NP 10 TARGET-30-PAPTAN AUTONOMIC GANGLIA c.1044G>A p.P348P COSMIC NP NP 11 TCGA-22-4591-01 LUNG c.712C>T p.R238W COSMIC NP NP 12 TCGA-49-4514-01 LUNG c.865G>C p.E289Q COSMIC NP NP 13 TCGA-59-2372-01 OVARY c.930C>T p.H310H COSMIC NP NP 14 TCGA-61-2613-01 OVARY c.428C>T p.S143L COSMIC NP NP 15 TCGA-91-6840-01 LUNG c.970C>A p.R324R COSMIC NP NP 16 TCGA-AA-3864-01 LARGE INTESTINE c.759C>T p.T253T COSMIC NP NP 17 TCGA-AA-A01R-01 LARGE INTESTINE c.199C>T p.R67C COSMIC NP NP 18 TCGA-AA-A01R-01 LARGE INTESTINE c.698C>T p.T233I COSMIC NP NP 19 TCGA-AF-2693-01 LARGE INTESTINE c.849C>T p.C283C COSMIC NP NP 20 TCGA-AP-A051-01 ENDOMETRIUM c.738C>T p.H246H COSMIC NP NP 21 TCGA-AP-A051-01 ENDOMETRIUM c.981G>A p.A327A COSMIC NP NP 22 TCGA-AP-A056-01 ENDOMETRIUM c.931G>T p.D311Y COSMIC NP NP 23 TCGA-AZ-4315-01 LARGE INTESTINE c.958C>A p.L320I COSMIC NP NP 24 TCGA-B5-A11J-01 ENDOMETRIUM c.403G>A p.A135T COSMIC NP NP 25 TCGA-BH-A0C7-01 BREAST c.1041C>A p.H347Q COSMIC NP Benign 26 TCGA-BT-A0YX-01 URINARY TRACT c.217G>A p.E73K COSMIC NP NP 27 TCGA-CH-5738-01 PROSTATE c.267C>T p.A89A COSMIC NP NP 28 TCGA-CH-5750-01 PROSTATE c.267C>T p.A89A COSMIC NP NP 29 TCGA-CM-5868-01 LARGE INTESTINE c.267C>T p.A89A COSMIC NP NP 30 TCGA-CM-6162-01 LARGE INTESTINE c.322G>A p.A108T COSMIC NP NP 31 TCGA-D1-A17H-01 ENDOMETRIUM c.283C>T p.R95* COSMIC NP NP 32 TCGA-DK-A1AC-01 URINARY TRACT c.8G>A p.R3K COSMIC NP NP 33 TCGA-EJ-5519-01 PROSTATE c.267C>T p.A89A COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
-
Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
-
Structure Domains (+)
-
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
-
Post Translational Modifications (+)
S. No. Position Amino acid Type 1 100 S Phosphorylation 2 100 S Phosphorylation 3 151 K Sumoylation 4 172 K Sumoylation 5 236 K Ubiquitylation 6 245 K Ubiquitylation 7 255 K Ubiquitylation 8 267 K Ubiquitylation 9 382 K Ubiquitylation 10 96 Y Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SETD8 SETD8 SETD8 ENSP00000332995 Q9NQR1 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q9NQR1 SETD8 ENSP00000332995 SETD8 Q9NQR1 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SETD8 ENSP00000332995 607240 Q9NQR1 PA143485616
