dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SETDB1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 ACCMESO1 PLEURA c.395_399delTCCTC p.V132fs CCLE NP NP 2 AN3CA ENDOMETRIUM c.3659G>A p.R1220H CCLE PASSENGER/OTHER Probably Damaging 3 BT483 BREAST c.302C>G p.S101C CCLE PASSENGER/OTHER Probably Damaging 4 CMLT1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1402_1403insC p.S468fs CCLE NP NP 5 COLO201 LARGE INTESTINE c.796G>A p.A266T CCLE PASSENGER/OTHER Probably Damaging 6 COLO205 LARGE INTESTINE c.796G>A p.A266T CCLE PASSENGER/OTHER Probably Damaging 7 DND41 HAEMATOPOIETIC AND LYMPHOID TISSUE c.541C>T p.H181Y CCLE PASSENGER/OTHER Benign 8 EN ENDOMETRIUM c.1141_splice p.D381_splice CCLE NP NP 9 GP2D LARGE INTESTINE c.1574C>T p.T525I CCLE PASSENGER/OTHER Benign 10 GP2D LARGE INTESTINE c.2844_2844delC p.H948fs CCLE NP NP 11 HEC151 ENDOMETRIUM c.232G>A p.V78I CCLE PASSENGER/OTHER Benign 12 HEC6 ENDOMETRIUM c.216A>T p.E72D CCLE PASSENGER/OTHER Probably Damaging 13 IGROV1 OVARY c.3709G>A p.V1237M CCLE PASSENGER/OTHER Probably Damaging 14 ISHIKAWAHERAKLIO02ER ENDOMETRIUM c.2315A>C p.E772A CCLE PASSENGER/OTHER Probably Damaging 15 KMS26 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3236_3237AG>TA p.K1079I CCLE PASSENGER/OTHER Probably Damaging 16 KMS34 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3829C>A p.L1277I CCLE PASSENGER/OTHER Probably Damaging 17 KYO1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.707A>G p.N236S CCLE PASSENGER/OTHER Benign 18 KYSE30 OESOPHAGUS c.2086G>C p.E696Q CCLE PASSENGER/OTHER Probably Damaging 19 LNCAPCLONEFGC PROSTATE c.2920G>A p.E974K CCLE PASSENGER/OTHER Probably Damaging 20 LS180 LARGE INTESTINE c.3059A>C p.E1020A CCLE PASSENGER/OTHER Benign 21 MDAMB361 BREAST c.3053G>A p.R1018Q CCLE PASSENGER/OTHER Benign 22 MFE319 ENDOMETRIUM c.950_splice p.L317_splice CCLE NP NP 23 MKN74 STOMACH c.2740G>A p.E914K CCLE PASSENGER/OTHER Possibly Damaging 24 NCIH1092 LUNG c.3269C>A p.A1090D CCLE PASSENGER/OTHER Benign 25 NCIH1341 LUNG c.3484_3507delAAATCAACCCGAGGCTTTGCTCTT p.KSTRGFAL1162del CCLE NP NP 26 NCIH1734 LUNG c.3672C>A p.H1224Q CCLE PASSENGER/OTHER Probably Damaging 27 NCIH196 LUNG c.1280G>T p.S427I CCLE PASSENGER/OTHER Probably Damaging 28 NCIH510 LUNG c.3347G>A p.R1116Q CCLE PASSENGER/OTHER Benign 29 NCIH510 LUNG c.3765C>G p.I1255M CCLE PASSENGER/OTHER Probably Damaging 30 OAW28 OVARY c.1232A>G p.K411R CCLE PASSENGER/OTHER Benign 31 OCIAML2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.13C>T p.P5S CCLE PASSENGER/OTHER Benign 32 ONS76 CENTRAL NERVOUS SYSTEM c.2603A>C p.E868A CCLE PASSENGER/OTHER Probably Damaging 33 OVISE OVARY c.3562G>A p.G1188R CCLE PASSENGER/OTHER Probably Damaging 34 PANC0327 PANCREAS c.1619C>T p.S540L CCLE PASSENGER/OTHER Benign 35 PANC0327 PANCREAS c.1646C>G p.P549R CCLE PASSENGER/OTHER Benign 36 PANC0327 PANCREAS c.1933C>G p.L645V CCLE PASSENGER/OTHER Probably Damaging 37 PF382 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2207G>A p.R736Q CCLE CANCER Probably Damaging 38 RKN SOFT TISSUE c.707A>G p.N236S CCLE PASSENGER/OTHER Benign 39 RKO LARGE INTESTINE c.2621_2621delC p.A874fs CCLE NP NP 40 SNGM ENDOMETRIUM c.3380C>T p.A1127V CCLE PASSENGER/OTHER Probably Damaging 41 SNU349 KIDNEY c.2453G>A p.R818H CCLE PASSENGER/OTHER Probably Damaging 42 SNU620 STOMACH c.707A>G p.N236S CCLE PASSENGER/OTHER Benign 43 SNU878 LIVER c.2183G>T p.G728V CCLE CANCER Probably Damaging 44 SW1573 LUNG c.2086G>A p.E696K CCLE PASSENGER/OTHER Probably Damaging 45 TGBC11TKB STOMACH c.764C>T p.A255V CCLE PASSENGER/OTHER Benign 46 BB30-HNC UPPER AERODIGESTIVE TRACT c.370G>C p.E124Q COSMIC PASSENGER/OTHER Probably Damaging 47 BN17T LIVER c.2503A>G p.K835E COSMIC PASSENGER/OTHER Probably Damaging 48 CLL064 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2143A>G p.K715E COSMIC CANCER Benign 49 CLL109 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3080C>G p.S1027* COSMIC NP NP 50 COLO-205 LARGE INTESTINE c.796G>A p.A266T COSMIC PASSENGER/OTHER Probably Damaging 51 Case4 NS c.3820G>A p.G1274S COSMIC PASSENGER/OTHER Probably Damaging 52 ESO-0023 OESOPHAGUS c.2149G>A p.V717I COSMIC CANCER Probably Damaging 53 ESO-0292 OESOPHAGUS c.3281C>G p.S1094C COSMIC PASSENGER/OTHER Possibly Damaging 54 ESO-077 OESOPHAGUS c.1069G>C p.E357Q COSMIC PASSENGER/OTHER Probably Damaging 55 ESO-682 OESOPHAGUS c.2782C>T p.R928W COSMIC PASSENGER/OTHER Probably Damaging 56 ESO-859 OESOPHAGUS c.284T>C p.L95S COSMIC PASSENGER/OTHER Probably Damaging 57 HCC109T LIVER c.3028delG p.E1011fs*19 COSMIC NP NP 58 HCC48T LIVER c.297C>T p.F99F COSMIC NP NP 59 HCC70T LIVER c.2560T>G p.F854V COSMIC PASSENGER/OTHER Probably Damaging 60 HX17T LIVER c.2779A>C p.T927P COSMIC PASSENGER/OTHER Probably Damaging 61 IGROV-1 OVARY c.3709G>A p.V1237M COSMIC PASSENGER/OTHER Probably Damaging 62 PD4203a NS c.1458G>A p.Q486Q COSMIC NP NP 63 RK044_C01 LIVER c.3447G>C p.K1149N COSMIC PASSENGER/OTHER Probably Damaging 64 RK056_C01 LIVER c.3632A>T p.D1211V COSMIC PASSENGER/OTHER Probably Damaging 65 RK056_C01 LIVER c.3638A>T p.K1213M COSMIC PASSENGER/OTHER Probably Damaging 66 RK056_C01 LIVER c.3642T>G p.L1214L COSMIC NP NP 67 RK126_C01 LIVER c.1180C>T p.R394W COSMIC PASSENGER/OTHER Probably Damaging 68 RK167_C01 LIVER c.1493C>G p.S498C COSMIC PASSENGER/OTHER Probably Damaging 69 TCGA-04-1525-01 OVARY c.911A>G p.Y304C COSMIC PASSENGER/OTHER Probably Damaging 70 TCGA-13-1507-01 OVARY c.1511C>G p.S504C COSMIC PASSENGER/OTHER Probably Damaging 71 TCGA-21-1070-01 LUNG c.3565G>C p.E1189Q COSMIC PASSENGER/OTHER Benign 72 TCGA-21-1081-01 LUNG c.1226T>C p.L409P COSMIC PASSENGER/OTHER Benign 73 TCGA-23-1029-01 OVARY c.615G>C p.L205L COSMIC NP NP 74 TCGA-34-2600-01 LUNG c.2462A>G p.D821G COSMIC PASSENGER/OTHER Probably Damaging 75 TCGA-35-5375-01 LUNG c.2913T>G p.P971P COSMIC NP NP 76 TCGA-60-2725-01 LUNG c.942C>T p.C314C COSMIC NP NP 77 TCGA-61-1919-01 OVARY c.2090T>C p.I697T COSMIC PASSENGER/OTHER Benign 78 TCGA-66-2763-01 LUNG c.99G>T p.L33L COSMIC NP NP 79 TCGA-67-3771-01 LUNG c.3364C>G p.Q1122E COSMIC PASSENGER/OTHER Benign 80 TCGA-73-4666-01 LUNG c.3175C>G p.R1059G COSMIC PASSENGER/OTHER Benign 81 TCGA-86-6562-01 LUNG c.920A>T p.Q307L COSMIC PASSENGER/OTHER Benign 82 TCGA-A2-A04P-01 BREAST c.2536G>T p.G846C COSMIC PASSENGER/OTHER Probably Damaging 83 TCGA-A3-3374-01 KIDNEY c.945G>A p.R315R COSMIC NP NP 84 TCGA-A5-A0GI-01 ENDOMETRIUM c.2193C>T p.C731C COSMIC NP NP 85 TCGA-A6-5657-01 LARGE INTESTINE c.371A>G p.E124G COSMIC PASSENGER/OTHER Probably Damaging 86 TCGA-AA-3510-01 LARGE INTESTINE c.214G>T p.E72* COSMIC NP NP 87 TCGA-AA-3554-01 LARGE INTESTINE c.2812G>A p.G938R COSMIC PASSENGER/OTHER Possibly Damaging 88 TCGA-AA-3663-01 LARGE INTESTINE c.2046C>T p.I682I COSMIC NP NP 89 TCGA-AA-3663-01 LARGE INTESTINE c.3581G>A p.R1194H COSMIC PASSENGER/OTHER Benign 90 TCGA-AA-3947-01 LARGE INTESTINE c.769A>G p.K257E COSMIC PASSENGER/OTHER Benign 91 TCGA-AA-A00D-01 LARGE INTESTINE c.1753C>T p.R585* COSMIC NP NP 92 TCGA-AA-A00E-01 LARGE INTESTINE c.1407C>A p.P469P COSMIC NP NP 93 TCGA-AA-A00F-01 LARGE INTESTINE c.1826G>A p.R609Q COSMIC PASSENGER/OTHER Probably Damaging 94 TCGA-AN-A04C-01 BREAST c.3176G>A p.R1059Q COSMIC PASSENGER/OTHER Benign 95 TCGA-AP-A051-01 ENDOMETRIUM c.268A>G p.T90A COSMIC PASSENGER/OTHER Benign 96 TCGA-AP-A051-01 ENDOMETRIUM c.3801C>T p.Y1267Y COSMIC NP NP 97 TCGA-AP-A054-01 ENDOMETRIUM c.2604A>T p.E868D COSMIC PASSENGER/OTHER Probably Damaging 98 TCGA-AP-A059-01 ENDOMETRIUM c.2901C>A p.G967G COSMIC NP NP 99 TCGA-AP-A059-01 ENDOMETRIUM c.3214G>T p.G1072* COSMIC NP NP 100 TCGA-AP-A0LM-01 ENDOMETRIUM c.243C>A p.L81L COSMIC NP NP 101 TCGA-AP-A0LN-01 ENDOMETRIUM c.3695T>G p.V1232G COSMIC PASSENGER/OTHER Probably Damaging 102 TCGA-AX-A05Z-01 ENDOMETRIUM c.3727C>T p.R1243C COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-AX-A0J1-01 ENDOMETRIUM c.3609C>T p.G1203G COSMIC NP NP 104 TCGA-AZ-6598-01 LARGE INTESTINE c.3766C>T p.R1256W COSMIC PASSENGER/OTHER Probably Damaging 105 TCGA-B5-A0JY-01 ENDOMETRIUM c.80A>G p.Q27R COSMIC PASSENGER/OTHER Benign 106 TCGA-B5-A11E-01 ENDOMETRIUM c.607C>T p.R203* COSMIC NP NP 107 TCGA-B5-A11N-01 ENDOMETRIUM c.2471C>T p.A824V COSMIC PASSENGER/OTHER Probably Damaging 108 TCGA-BG-A0M4-01 ENDOMETRIUM c.2549G>A p.G850D COSMIC PASSENGER/OTHER Probably Damaging 109 TCGA-BG-A0VZ-01 ENDOMETRIUM c.1483C>T p.R495* COSMIC NP NP 110 TCGA-BH-A1F8-01 BREAST c.2343_2344insA p.N782fs*7 COSMIC NP NP 111 TCGA-BS-A0UF-01 ENDOMETRIUM c.1938C>T p.F646F COSMIC NP NP 112 TCGA-BS-A0UF-01 ENDOMETRIUM c.3176G>A p.R1059Q COSMIC PASSENGER/OTHER Benign 113 TCGA-BS-A0UJ-01 ENDOMETRIUM c.1842G>A p.R614R COSMIC NP NP 114 TCGA-BS-A0UM-01 ENDOMETRIUM c.3138C>T p.D1046D COSMIC NP NP 115 TCGA-BS-A0UV-01 ENDOMETRIUM c.3580C>T p.R1194C COSMIC PASSENGER/OTHER Benign 116 TCGA-C8-A12L-01 BREAST c.2288C>G p.S763C COSMIC PASSENGER/OTHER Probably Damaging 117 TCGA-C8-A12Q-01 BREAST c.2288C>T p.S763F COSMIC PASSENGER/OTHER Probably Damaging 118 TCGA-CA-5796-01 LARGE INTESTINE c.912T>C p.Y304Y COSMIC NP NP 119 TCGA-CK-4950-01 LARGE INTESTINE c.371A>G p.E124G COSMIC PASSENGER/OTHER Probably Damaging 120 TCGA-D1-A103-01 ENDOMETRIUM c.1493C>A p.S498Y COSMIC PASSENGER/OTHER Probably Damaging 121 TCGA-D1-A103-01 ENDOMETRIUM c.3536C>T p.S1179L COSMIC PASSENGER/OTHER Probably Damaging 122 TCGA-D1-A103-01 ENDOMETRIUM c.56C>T p.S19F COSMIC PASSENGER/OTHER Possibly Damaging 123 TCGA-D5-6930-01 LARGE INTESTINE c.1028G>A p.R343H COSMIC PASSENGER/OTHER Probably Damaging 124 TCGA-DK-A3IT-01 URINARY TRACT c.2086G>C p.E696Q COSMIC PASSENGER/OTHER Probably Damaging 125 TCGA-E5-A2PC-01 URINARY TRACT c.1675C>T p.P559S COSMIC PASSENGER/OTHER Probably Damaging 126 TCGA-F4-6855-01 LARGE INTESTINE c.1511C>A p.S504Y COSMIC PASSENGER/OTHER Probably Damaging 127 TCGA-F4-6856-01 LARGE INTESTINE c.2767C>T p.R923W COSMIC PASSENGER/OTHER Probably Damaging 128 TCGA-G4-6588-01 LARGE INTESTINE c.3767G>A p.R1256Q COSMIC PASSENGER/OTHER Probably Damaging 129 TCGA-G4-6588-01 LARGE INTESTINE c.989G>A p.R330H COSMIC PASSENGER/OTHER Probably Damaging 130 cSCCP7 SKIN c.3706T>C p.F1236L COSMIC PASSENGER/OTHER Probably Damaging 131 cSCCP8 SKIN c.1606G>T p.A536S COSMIC PASSENGER/OTHER Benign 132 ccRCC-1 KIDNEY c.2881delC p.S962fs*4 COSMIC NP NP 133 pfg011T STOMACH c.1315A>G p.T439A COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Sequence alignment with CCLE mutants:3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
