dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SETDB1 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 ACCMESO1 PLEURA c.395_399delTCCTC p.V132fs CCLE NP NP 2 AN3CA ENDOMETRIUM c.3659G>A p.R1220H CCLE PASSENGER/OTHER Probably Damaging 3 BT483 BREAST c.302C>G p.S101C CCLE PASSENGER/OTHER Probably Damaging 4 CMLT1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1402_1403insC p.S468fs CCLE NP NP 5 COLO201 LARGE INTESTINE c.796G>A p.A266T CCLE PASSENGER/OTHER Probably Damaging 6 COLO205 LARGE INTESTINE c.796G>A p.A266T CCLE PASSENGER/OTHER Probably Damaging 7 DND41 HAEMATOPOIETIC AND LYMPHOID TISSUE c.541C>T p.H181Y CCLE PASSENGER/OTHER Benign 8 EN ENDOMETRIUM c.1141_splice p.D381_splice CCLE NP NP 9 GP2D LARGE INTESTINE c.1574C>T p.T525I CCLE PASSENGER/OTHER Benign 10 GP2D LARGE INTESTINE c.2844_2844delC p.H948fs CCLE NP NP 11 HEC151 ENDOMETRIUM c.232G>A p.V78I CCLE PASSENGER/OTHER Benign 12 HEC6 ENDOMETRIUM c.216A>T p.E72D CCLE PASSENGER/OTHER Probably Damaging 13 IGROV1 OVARY c.3709G>A p.V1237M CCLE PASSENGER/OTHER Probably Damaging 14 ISHIKAWAHERAKLIO02ER ENDOMETRIUM c.2315A>C p.E772A CCLE PASSENGER/OTHER Probably Damaging 15 KMS26 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3236_3237AG>TA p.K1079I CCLE PASSENGER/OTHER Probably Damaging 16 KMS34 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3829C>A p.L1277I CCLE PASSENGER/OTHER Probably Damaging 17 KYO1 HAEMATOPOIETIC AND LYMPHOID TISSUE c.707A>G p.N236S CCLE PASSENGER/OTHER Benign 18 KYSE30 OESOPHAGUS c.2086G>C p.E696Q CCLE PASSENGER/OTHER Probably Damaging 19 LNCAPCLONEFGC PROSTATE c.2920G>A p.E974K CCLE PASSENGER/OTHER Probably Damaging 20 LS180 LARGE INTESTINE c.3059A>C p.E1020A CCLE PASSENGER/OTHER Benign 21 MDAMB361 BREAST c.3053G>A p.R1018Q CCLE PASSENGER/OTHER Benign 22 MFE319 ENDOMETRIUM c.950_splice p.L317_splice CCLE NP NP 23 MKN74 STOMACH c.2740G>A p.E914K CCLE PASSENGER/OTHER Possibly Damaging 24 NCIH1092 LUNG c.3269C>A p.A1090D CCLE PASSENGER/OTHER Benign 25 NCIH1341 LUNG c.3484_3507delAAATCAACCCGAGGCTTTGCTCTT p.KSTRGFAL1162del CCLE NP NP 26 NCIH1734 LUNG c.3672C>A p.H1224Q CCLE PASSENGER/OTHER Probably Damaging 27 NCIH196 LUNG c.1280G>T p.S427I CCLE PASSENGER/OTHER Probably Damaging 28 NCIH510 LUNG c.3347G>A p.R1116Q CCLE PASSENGER/OTHER Benign 29 NCIH510 LUNG c.3765C>G p.I1255M CCLE PASSENGER/OTHER Probably Damaging 30 OAW28 OVARY c.1232A>G p.K411R CCLE PASSENGER/OTHER Benign 31 OCIAML2 HAEMATOPOIETIC AND LYMPHOID TISSUE c.13C>T p.P5S CCLE PASSENGER/OTHER Benign 32 ONS76 CENTRAL NERVOUS SYSTEM c.2603A>C p.E868A CCLE PASSENGER/OTHER Probably Damaging 33 OVISE OVARY c.3562G>A p.G1188R CCLE PASSENGER/OTHER Probably Damaging 34 PANC0327 PANCREAS c.1619C>T p.S540L CCLE PASSENGER/OTHER Benign 35 PANC0327 PANCREAS c.1646C>G p.P549R CCLE PASSENGER/OTHER Benign 36 PANC0327 PANCREAS c.1933C>G p.L645V CCLE PASSENGER/OTHER Probably Damaging 37 PF382 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2207G>A p.R736Q CCLE CANCER Probably Damaging 38 RKN SOFT TISSUE c.707A>G p.N236S CCLE PASSENGER/OTHER Benign 39 RKO LARGE INTESTINE c.2621_2621delC p.A874fs CCLE NP NP 40 SNGM ENDOMETRIUM c.3380C>T p.A1127V CCLE PASSENGER/OTHER Probably Damaging 41 SNU349 KIDNEY c.2453G>A p.R818H CCLE PASSENGER/OTHER Probably Damaging 42 SNU620 STOMACH c.707A>G p.N236S CCLE PASSENGER/OTHER Benign 43 SNU878 LIVER c.2183G>T p.G728V CCLE CANCER Probably Damaging 44 SW1573 LUNG c.2086G>A p.E696K CCLE PASSENGER/OTHER Probably Damaging 45 TGBC11TKB STOMACH c.764C>T p.A255V CCLE PASSENGER/OTHER Benign 46 BB30-HNC UPPER AERODIGESTIVE TRACT c.370G>C p.E124Q COSMIC PASSENGER/OTHER Probably Damaging 47 BN17T LIVER c.2503A>G p.K835E COSMIC PASSENGER/OTHER Probably Damaging 48 CLL064 HAEMATOPOIETIC AND LYMPHOID TISSUE c.2143A>G p.K715E COSMIC CANCER Benign 49 CLL109 HAEMATOPOIETIC AND LYMPHOID TISSUE c.3080C>G p.S1027* COSMIC NP NP 50 COLO-205 LARGE INTESTINE c.796G>A p.A266T COSMIC PASSENGER/OTHER Probably Damaging 51 Case4 NS c.3820G>A p.G1274S COSMIC PASSENGER/OTHER Probably Damaging 52 ESO-0023 OESOPHAGUS c.2149G>A p.V717I COSMIC CANCER Probably Damaging 53 ESO-0292 OESOPHAGUS c.3281C>G p.S1094C COSMIC PASSENGER/OTHER Possibly Damaging 54 ESO-077 OESOPHAGUS c.1069G>C p.E357Q COSMIC PASSENGER/OTHER Probably Damaging 55 ESO-682 OESOPHAGUS c.2782C>T p.R928W COSMIC PASSENGER/OTHER Probably Damaging 56 ESO-859 OESOPHAGUS c.284T>C p.L95S COSMIC PASSENGER/OTHER Probably Damaging 57 HCC109T LIVER c.3028delG p.E1011fs*19 COSMIC NP NP 58 HCC48T LIVER c.297C>T p.F99F COSMIC NP NP 59 HCC70T LIVER c.2560T>G p.F854V COSMIC PASSENGER/OTHER Probably Damaging 60 HX17T LIVER c.2779A>C p.T927P COSMIC PASSENGER/OTHER Probably Damaging 61 IGROV-1 OVARY c.3709G>A p.V1237M COSMIC PASSENGER/OTHER Probably Damaging 62 PD4203a NS c.1458G>A p.Q486Q COSMIC NP NP 63 RK044_C01 LIVER c.3447G>C p.K1149N COSMIC PASSENGER/OTHER Probably Damaging 64 RK056_C01 LIVER c.3632A>T p.D1211V COSMIC PASSENGER/OTHER Probably Damaging 65 RK056_C01 LIVER c.3638A>T p.K1213M COSMIC PASSENGER/OTHER Probably Damaging 66 RK056_C01 LIVER c.3642T>G p.L1214L COSMIC NP NP 67 RK126_C01 LIVER c.1180C>T p.R394W COSMIC PASSENGER/OTHER Probably Damaging 68 RK167_C01 LIVER c.1493C>G p.S498C COSMIC PASSENGER/OTHER Probably Damaging 69 TCGA-04-1525-01 OVARY c.911A>G p.Y304C COSMIC PASSENGER/OTHER Probably Damaging 70 TCGA-13-1507-01 OVARY c.1511C>G p.S504C COSMIC PASSENGER/OTHER Probably Damaging 71 TCGA-21-1070-01 LUNG c.3565G>C p.E1189Q COSMIC PASSENGER/OTHER Benign 72 TCGA-21-1081-01 LUNG c.1226T>C p.L409P COSMIC PASSENGER/OTHER Benign 73 TCGA-23-1029-01 OVARY c.615G>C p.L205L COSMIC NP NP 74 TCGA-34-2600-01 LUNG c.2462A>G p.D821G COSMIC PASSENGER/OTHER Probably Damaging 75 TCGA-35-5375-01 LUNG c.2913T>G p.P971P COSMIC NP NP 76 TCGA-60-2725-01 LUNG c.942C>T p.C314C COSMIC NP NP 77 TCGA-61-1919-01 OVARY c.2090T>C p.I697T COSMIC PASSENGER/OTHER Benign 78 TCGA-66-2763-01 LUNG c.99G>T p.L33L COSMIC NP NP 79 TCGA-67-3771-01 LUNG c.3364C>G p.Q1122E COSMIC PASSENGER/OTHER Benign 80 TCGA-73-4666-01 LUNG c.3175C>G p.R1059G COSMIC PASSENGER/OTHER Benign 81 TCGA-86-6562-01 LUNG c.920A>T p.Q307L COSMIC PASSENGER/OTHER Benign 82 TCGA-A2-A04P-01 BREAST c.2536G>T p.G846C COSMIC PASSENGER/OTHER Probably Damaging 83 TCGA-A3-3374-01 KIDNEY c.945G>A p.R315R COSMIC NP NP 84 TCGA-A5-A0GI-01 ENDOMETRIUM c.2193C>T p.C731C COSMIC NP NP 85 TCGA-A6-5657-01 LARGE INTESTINE c.371A>G p.E124G COSMIC PASSENGER/OTHER Probably Damaging 86 TCGA-AA-3510-01 LARGE INTESTINE c.214G>T p.E72* COSMIC NP NP 87 TCGA-AA-3554-01 LARGE INTESTINE c.2812G>A p.G938R COSMIC PASSENGER/OTHER Possibly Damaging 88 TCGA-AA-3663-01 LARGE INTESTINE c.2046C>T p.I682I COSMIC NP NP 89 TCGA-AA-3663-01 LARGE INTESTINE c.3581G>A p.R1194H COSMIC PASSENGER/OTHER Benign 90 TCGA-AA-3947-01 LARGE INTESTINE c.769A>G p.K257E COSMIC PASSENGER/OTHER Benign 91 TCGA-AA-A00D-01 LARGE INTESTINE c.1753C>T p.R585* COSMIC NP NP 92 TCGA-AA-A00E-01 LARGE INTESTINE c.1407C>A p.P469P COSMIC NP NP 93 TCGA-AA-A00F-01 LARGE INTESTINE c.1826G>A p.R609Q COSMIC PASSENGER/OTHER Probably Damaging 94 TCGA-AN-A04C-01 BREAST c.3176G>A p.R1059Q COSMIC PASSENGER/OTHER Benign 95 TCGA-AP-A051-01 ENDOMETRIUM c.268A>G p.T90A COSMIC PASSENGER/OTHER Benign 96 TCGA-AP-A051-01 ENDOMETRIUM c.3801C>T p.Y1267Y COSMIC NP NP 97 TCGA-AP-A054-01 ENDOMETRIUM c.2604A>T p.E868D COSMIC PASSENGER/OTHER Probably Damaging 98 TCGA-AP-A059-01 ENDOMETRIUM c.2901C>A p.G967G COSMIC NP NP 99 TCGA-AP-A059-01 ENDOMETRIUM c.3214G>T p.G1072* COSMIC NP NP 100 TCGA-AP-A0LM-01 ENDOMETRIUM c.243C>A p.L81L COSMIC NP NP 101 TCGA-AP-A0LN-01 ENDOMETRIUM c.3695T>G p.V1232G COSMIC PASSENGER/OTHER Probably Damaging 102 TCGA-AX-A05Z-01 ENDOMETRIUM c.3727C>T p.R1243C COSMIC PASSENGER/OTHER Probably Damaging 103 TCGA-AX-A0J1-01 ENDOMETRIUM c.3609C>T p.G1203G COSMIC NP NP 104 TCGA-AZ-6598-01 LARGE INTESTINE c.3766C>T p.R1256W COSMIC PASSENGER/OTHER Probably Damaging 105 TCGA-B5-A0JY-01 ENDOMETRIUM c.80A>G p.Q27R COSMIC PASSENGER/OTHER Benign 106 TCGA-B5-A11E-01 ENDOMETRIUM c.607C>T p.R203* COSMIC NP NP 107 TCGA-B5-A11N-01 ENDOMETRIUM c.2471C>T p.A824V COSMIC PASSENGER/OTHER Probably Damaging 108 TCGA-BG-A0M4-01 ENDOMETRIUM c.2549G>A p.G850D COSMIC PASSENGER/OTHER Probably Damaging 109 TCGA-BG-A0VZ-01 ENDOMETRIUM c.1483C>T p.R495* COSMIC NP NP 110 TCGA-BH-A1F8-01 BREAST c.2343_2344insA p.N782fs*7 COSMIC NP NP 111 TCGA-BS-A0UF-01 ENDOMETRIUM c.1938C>T p.F646F COSMIC NP NP 112 TCGA-BS-A0UF-01 ENDOMETRIUM c.3176G>A p.R1059Q COSMIC PASSENGER/OTHER Benign 113 TCGA-BS-A0UJ-01 ENDOMETRIUM c.1842G>A p.R614R COSMIC NP NP 114 TCGA-BS-A0UM-01 ENDOMETRIUM c.3138C>T p.D1046D COSMIC NP NP 115 TCGA-BS-A0UV-01 ENDOMETRIUM c.3580C>T p.R1194C COSMIC PASSENGER/OTHER Benign 116 TCGA-C8-A12L-01 BREAST c.2288C>G p.S763C COSMIC PASSENGER/OTHER Probably Damaging 117 TCGA-C8-A12Q-01 BREAST c.2288C>T p.S763F COSMIC PASSENGER/OTHER Probably Damaging 118 TCGA-CA-5796-01 LARGE INTESTINE c.912T>C p.Y304Y COSMIC NP NP 119 TCGA-CK-4950-01 LARGE INTESTINE c.371A>G p.E124G COSMIC PASSENGER/OTHER Probably Damaging 120 TCGA-D1-A103-01 ENDOMETRIUM c.1493C>A p.S498Y COSMIC PASSENGER/OTHER Probably Damaging 121 TCGA-D1-A103-01 ENDOMETRIUM c.3536C>T p.S1179L COSMIC PASSENGER/OTHER Probably Damaging 122 TCGA-D1-A103-01 ENDOMETRIUM c.56C>T p.S19F COSMIC PASSENGER/OTHER Possibly Damaging 123 TCGA-D5-6930-01 LARGE INTESTINE c.1028G>A p.R343H COSMIC PASSENGER/OTHER Probably Damaging 124 TCGA-DK-A3IT-01 URINARY TRACT c.2086G>C p.E696Q COSMIC PASSENGER/OTHER Probably Damaging 125 TCGA-E5-A2PC-01 URINARY TRACT c.1675C>T p.P559S COSMIC PASSENGER/OTHER Probably Damaging 126 TCGA-F4-6855-01 LARGE INTESTINE c.1511C>A p.S504Y COSMIC PASSENGER/OTHER Probably Damaging 127 TCGA-F4-6856-01 LARGE INTESTINE c.2767C>T p.R923W COSMIC PASSENGER/OTHER Probably Damaging 128 TCGA-G4-6588-01 LARGE INTESTINE c.3767G>A p.R1256Q COSMIC PASSENGER/OTHER Probably Damaging 129 TCGA-G4-6588-01 LARGE INTESTINE c.989G>A p.R330H COSMIC PASSENGER/OTHER Probably Damaging 130 cSCCP7 SKIN c.3706T>C p.F1236L COSMIC PASSENGER/OTHER Probably Damaging 131 cSCCP8 SKIN c.1606G>T p.A536S COSMIC PASSENGER/OTHER Benign 132 ccRCC-1 KIDNEY c.2881delC p.S962fs*4 COSMIC NP NP 133 pfg011T STOMACH c.1315A>G p.T439A COSMIC PASSENGER/OTHER Benign
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Sequence alignment with CCLE mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 1025 S Phosphorylation 2 1066 S Phosphorylation 3 1066 S Phosphorylation 4 110 S Phosphorylation 5 1101 T Phosphorylation 6 1103 S Phosphorylation 7 1104 S Phosphorylation 8 1106 T Phosphorylation 9 1108 S Phosphorylation 10 111 S Phosphorylation 11 1119 T Phosphorylation 12 112 S Phosphorylation 13 1124 S Phosphorylation 14 1130 S Phosphorylation 15 1135 T Phosphorylation 16 1137 S Phosphorylation 17 1138 S Phosphorylation 18 1140 S Phosphorylation 19 1179 S Phosphorylation 20 1179 S Phosphorylation 21 1180 T Phosphorylation 22 1180 T Phosphorylation 23 1190 S Phosphorylation 24 1190 S Phosphorylation 25 1197 T Phosphorylation 26 134 S Phosphorylation 27 137 S Phosphorylation 28 175 S Phosphorylation 29 175 S Phosphorylation 30 182 K Ubiquitylation 31 182 K Ubiquitylation 32 230 Y Phosphorylation 33 468 S Phosphorylation 34 474 S Phosphorylation 35 501 S Phosphorylation 36 504 S Phosphorylation 37 505 S Phosphorylation 38 507 T Phosphorylation 39 59 K Ubiquitylation 40 597 K Ubiquitylation 41 838 T Phosphorylation 42 838 T Phosphorylation 43 862 S Phosphorylation 44 872 S Phosphorylation 45 905 S Phosphorylation 46 906 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SETDB1 SETDB1 SETDB1 ENSP00000271640 Q15047 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q15047 SETDB1 ENSP00000271640 SETDB1 Q15047 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SETDB1 ENSP00000271640 604396 Q15047 PA35679
