dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SETMAR |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 H23 LUNG c.1984G>A p.A662T COSMIC NP NP 2 HCC52T LIVER c.437C>T p.T146M COSMIC NP NP 3 TARGET-30-PAPTAN AUTONOMIC GANGLIA c.4T>C p.F2L COSMIC NP NP 4 TCGA-13-1495-01 OVARY c.565G>A p.D189N COSMIC NP Benign 5 TCGA-44-4112-01 LUNG c.1243G>T p.D415Y COSMIC NP NP 6 TCGA-44-8119-01 LUNG c.163C>A p.P55T COSMIC NP Possibly Damaging 7 TCGA-A3-3311-01 KIDNEY c.637A>G p.T213A COSMIC NP NP 8 TCGA-A3-3346-01 KIDNEY c.679G>A p.E227K COSMIC NP NP 9 TCGA-A6-5661-01 LARGE INTESTINE c.480G>A p.P160P COSMIC NP NP 10 TCGA-A8-A09N-01 BREAST c.947G>C p.G316A COSMIC NP NP 11 TCGA-AA-3815-01 LARGE INTESTINE c.419A>G p.H140R COSMIC NP NP 12 TCGA-AA-3815-01 LARGE INTESTINE c.442delA p.G150fs*24 COSMIC NP NP 13 TCGA-AA-3977-01 LARGE INTESTINE c.1959C>T p.V653V COSMIC NP NP 14 TCGA-AG-A002-01 LARGE INTESTINE c.1006C>T p.R336* COSMIC NP NP 15 TCGA-AP-A0LE-01 ENDOMETRIUM c.1228T>A p.S410T COSMIC NP NP 16 TCGA-AP-A0LE-01 ENDOMETRIUM c.1517G>A p.R506Q COSMIC NP NP 17 TCGA-AP-A0LH-01 ENDOMETRIUM c.1387_1388insA p.L464fs*3 COSMIC NP NP 18 TCGA-AP-A0LM-01 ENDOMETRIUM c.460C>T p.R154C COSMIC NP NP 19 TCGA-AR-A1AY-01 BREAST c.1601C>T p.T534I COSMIC NP NP 20 TCGA-AX-A05Z-01 ENDOMETRIUM c.1149A>G p.E383E COSMIC NP NP 21 TCGA-B2-4102-01 KIDNEY c.45G>A p.A15A COSMIC NP NP 22 TCGA-B5-A0JV-01 ENDOMETRIUM c.1516C>T p.R506* COSMIC NP NP 23 TCGA-B5-A0JY-01 ENDOMETRIUM c.1689C>T p.I563I COSMIC NP NP 24 TCGA-B5-A0JY-01 ENDOMETRIUM c.774C>A p.L258L COSMIC NP NP 25 TCGA-BS-A0UV-01 ENDOMETRIUM c.1689C>T p.I563I COSMIC NP NP 26 TCGA-BS-A0UV-01 ENDOMETRIUM c.1880T>G p.F627C COSMIC NP NP 27 TCGA-CK-5916-01 LARGE INTESTINE c.96C>T p.C32C COSMIC NP NP 28 TCGA-CM-5861-01 LARGE INTESTINE c.344delT p.F116fs*58 COSMIC NP NP 29 TCGA-D1-A16X-01 ENDOMETRIUM c.1368C>T p.L456L COSMIC NP NP 30 TCGA-D5-6928-01 LARGE INTESTINE c.450C>T p.G150G COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
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Structure Domains (+)
1. PFAM Domains:Domain ID Domain Name Start Site End Site E-value PF05033 Pre-SET 48 131 1.6e-13 PF00856 SET 150 262 2.8e-22 PB005810 Pfam-B_5810 346 496 2.1e-06 PB011211 Pfam-B_11211 347 433 7.6e-14 PB004892 Pfam-B_4892 348 394 2.5e-06 PB012545 Pfam-B_12545 368 489 4.2e-33 PF01498 HTH_Tnp_Tc3_2 415 476 7.8e-06 PF01359 Transposase_1 501 581 3.9e-30 PB010046 Pfam-B_10046 579 683 9.3e-19 PB004053 Pfam-B_4053 587 639 1.2e-19 PB003712 Pfam-B_3712 589 680 2.8e-25 PB004892 Pfam-B_4892 618 683 5.1e-07 -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
