dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SIRT2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 LAU165 SKIN c.697G>A p.V233I COSMIC PASSENGER/OTHER Possibly Damaging 2 LC_C6 LUNG c.697G>A p.V233I COSMIC PASSENGER/OTHER Possibly Damaging 3 LC_S19 LUNG c.1156G>T p.E386* COSMIC NP NP 4 S00936 LUNG c.654G>A p.T218T COSMIC NP NP 5 SWE-55B PROSTATE c.718C>A p.P240T COSMIC PASSENGER/OTHER Probably Damaging 6 TCGA-18-4083-01 LUNG c.125G>C p.R42P COSMIC PASSENGER/OTHER Probably Damaging 7 TCGA-37-5819-01 LUNG c.529G>T p.G177W COSMIC CANCER Probably Damaging 8 TCGA-60-2712-01 LUNG c.219C>A p.S73R COSMIC PASSENGER/OTHER Benign 9 TCGA-69-7765-01 LUNG c.1158G>C p.E386D COSMIC PASSENGER/OTHER Probably Damaging 10 TCGA-AA-3558-01 LARGE INTESTINE c.85G>A p.G29R COSMIC PASSENGER/OTHER Benign 11 TCGA-AG-A02N-01 LARGE INTESTINE c.568T>G p.F190V COSMIC PASSENGER/OTHER Possibly Damaging 12 TCGA-AP-A051-01 ENDOMETRIUM c.457C>T p.R153C COSMIC PASSENGER/OTHER Probably Damaging 13 TCGA-AP-A054-01 ENDOMETRIUM c.608A>G p.E203G COSMIC PASSENGER/OTHER Possibly Damaging 14 TCGA-AP-A059-01 ENDOMETRIUM c.1021C>A p.L341M COSMIC CANCER Possibly Damaging 15 TCGA-AP-A059-01 ENDOMETRIUM c.557C>T p.A186V COSMIC PASSENGER/OTHER Probably Damaging 16 TCGA-AP-A0LM-01 ENDOMETRIUM c.951C>T p.D317D COSMIC NP NP 17 TCGA-B5-A0JV-01 ENDOMETRIUM c.94G>A p.A32T COSMIC PASSENGER/OTHER Benign 18 TCGA-B5-A0JY-01 ENDOMETRIUM c.585C>T p.C195C COSMIC NP NP 19 TCGA-CM-5341-01 LARGE INTESTINE c.1074G>A p.A358A COSMIC NP NP 20 TCGA-CM-6162-01 LARGE INTESTINE c.586G>A p.V196I COSMIC PASSENGER/OTHER Benign 21 TCGA-D1-A17Q-01 ENDOMETRIUM c.383C>T p.P128L COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-D1-A17Q-01 ENDOMETRIUM c.419C>A p.P140H COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-D8-A1Y3-01 BREAST c.1036C>T p.R346W COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-E2-A10C-01 BREAST c.756G>A p.L252L COSMIC NP NP 25 YUKLAB SKIN c.803_804CC>TT p.P268L COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
