dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SIRT2 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 LAU165 SKIN c.697G>A p.V233I COSMIC PASSENGER/OTHER Possibly Damaging 2 LC_C6 LUNG c.697G>A p.V233I COSMIC PASSENGER/OTHER Possibly Damaging 3 LC_S19 LUNG c.1156G>T p.E386* COSMIC NP NP 4 S00936 LUNG c.654G>A p.T218T COSMIC NP NP 5 SWE-55B PROSTATE c.718C>A p.P240T COSMIC PASSENGER/OTHER Probably Damaging 6 TCGA-18-4083-01 LUNG c.125G>C p.R42P COSMIC PASSENGER/OTHER Probably Damaging 7 TCGA-37-5819-01 LUNG c.529G>T p.G177W COSMIC CANCER Probably Damaging 8 TCGA-60-2712-01 LUNG c.219C>A p.S73R COSMIC PASSENGER/OTHER Benign 9 TCGA-69-7765-01 LUNG c.1158G>C p.E386D COSMIC PASSENGER/OTHER Probably Damaging 10 TCGA-AA-3558-01 LARGE INTESTINE c.85G>A p.G29R COSMIC PASSENGER/OTHER Benign 11 TCGA-AG-A02N-01 LARGE INTESTINE c.568T>G p.F190V COSMIC PASSENGER/OTHER Possibly Damaging 12 TCGA-AP-A051-01 ENDOMETRIUM c.457C>T p.R153C COSMIC PASSENGER/OTHER Probably Damaging 13 TCGA-AP-A054-01 ENDOMETRIUM c.608A>G p.E203G COSMIC PASSENGER/OTHER Possibly Damaging 14 TCGA-AP-A059-01 ENDOMETRIUM c.1021C>A p.L341M COSMIC CANCER Possibly Damaging 15 TCGA-AP-A059-01 ENDOMETRIUM c.557C>T p.A186V COSMIC PASSENGER/OTHER Probably Damaging 16 TCGA-AP-A0LM-01 ENDOMETRIUM c.951C>T p.D317D COSMIC NP NP 17 TCGA-B5-A0JV-01 ENDOMETRIUM c.94G>A p.A32T COSMIC PASSENGER/OTHER Benign 18 TCGA-B5-A0JY-01 ENDOMETRIUM c.585C>T p.C195C COSMIC NP NP 19 TCGA-CM-5341-01 LARGE INTESTINE c.1074G>A p.A358A COSMIC NP NP 20 TCGA-CM-6162-01 LARGE INTESTINE c.586G>A p.V196I COSMIC PASSENGER/OTHER Benign 21 TCGA-D1-A17Q-01 ENDOMETRIUM c.383C>T p.P128L COSMIC PASSENGER/OTHER Probably Damaging 22 TCGA-D1-A17Q-01 ENDOMETRIUM c.419C>A p.P140H COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-D8-A1Y3-01 BREAST c.1036C>T p.R346W COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-E2-A10C-01 BREAST c.756G>A p.L252L COSMIC NP NP 25 YUKLAB SKIN c.803_804CC>TT p.P268L COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 2 A Acetylation 2 23 S Phosphorylation 3 23 S Phosphorylation 4 25 S Phosphorylation 5 25 S Phosphorylation 6 27 S Phosphorylation 7 27 S Phosphorylation 8 364 S Phosphorylation 9 365 T Phosphorylation 10 366 S Phosphorylation 11 368 S Phosphorylation 12 368 S Phosphorylation 13 368 S Phosphorylation 14 372 S Phosphorylation 15 372 S Phosphorylation 16 46 S Phosphorylation 17 55 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SIRT2 SIRT2 SIRT2 ENSP00000249396 Q8IXJ6 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q8IXJ6 SIRT2 ENSP00000249396 SIRT2 Q8IXJ6 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SIRT2 ENSP00000249396 604480 Q8IXJ6 PA35786
