dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SIRT6 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587376 LARGE INTESTINE c.246C>A p.F82L COSMIC PASSENGER/OTHER Benign 2 9534 SALIVARY GLAND c.80C>G p.P27R COSMIC PASSENGER/OTHER Probably Damaging 3 CP66-MEL SKIN c.23G>A p.G8E COSMIC PASSENGER/OTHER Probably Damaging 4 LUAD-AEIUF LUNG c.73G>A p.D25N COSMIC PASSENGER/OTHER Probably Damaging 5 LUAD-B01169 LUNG c.243G>T p.K81N COSMIC PASSENGER/OTHER Benign 6 MD-146 CENTRAL NERVOUS SYSTEM c.404delA p.N135fs*25 COSMIC NP NP 7 TARGET-30-PAPLSD AUTONOMIC GANGLIA c.15C>T p.Y5Y COSMIC NP NP 8 TCGA-21-1071-01 LUNG c.778G>T p.E260* COSMIC NP NP 9 TCGA-24-2281-01 OVARY c.789C>T p.T263T COSMIC NP NP 10 TCGA-33-4532-01 LUNG c.346G>A p.D116N COSMIC PASSENGER/OTHER Probably Damaging 11 TCGA-36-2538-01 OVARY c.1002G>A p.E334E COSMIC NP NP 12 TCGA-66-2768-01 LUNG c.265G>T p.A89S COSMIC PASSENGER/OTHER Probably Damaging 13 TCGA-A6-6649-01 LARGE INTESTINE c.23G>A p.G8E COSMIC PASSENGER/OTHER Probably Damaging 14 TCGA-C8-A12W-01 BREAST c.137G>A p.S46N COSMIC PASSENGER/OTHER Benign 15 TCGA-CJ-4905-01 KIDNEY c.107A>T p.E36V COSMIC PASSENGER/OTHER Benign 16 TCGA-F4-6460-01 LARGE INTESTINE c.483C>T p.A161A COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 10 S Phosphorylation 2 160 K Ubiquitylation 3 2 S Acetylation 4 267 K Ubiquitylation 5 294 T Phosphorylation 6 294 T Phosphorylation 7 303 S Phosphorylation 8 303 S Phosphorylation 9 330 S Phosphorylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SIRT6 SIRT6 SIRT6 ENSP00000305310 Q8N6T7 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q8N6T7 SIRT6 ENSP00000305310 SIRT6 Q8N6T7 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SIRT6 ENSP00000305310 606211 Q8N6T7 PA37939
