dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SIRT6 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587376 LARGE INTESTINE c.246C>A p.F82L COSMIC PASSENGER/OTHER Benign 2 9534 SALIVARY GLAND c.80C>G p.P27R COSMIC PASSENGER/OTHER Probably Damaging 3 CP66-MEL SKIN c.23G>A p.G8E COSMIC PASSENGER/OTHER Probably Damaging 4 LUAD-AEIUF LUNG c.73G>A p.D25N COSMIC PASSENGER/OTHER Probably Damaging 5 LUAD-B01169 LUNG c.243G>T p.K81N COSMIC PASSENGER/OTHER Benign 6 MD-146 CENTRAL NERVOUS SYSTEM c.404delA p.N135fs*25 COSMIC NP NP 7 TARGET-30-PAPLSD AUTONOMIC GANGLIA c.15C>T p.Y5Y COSMIC NP NP 8 TCGA-21-1071-01 LUNG c.778G>T p.E260* COSMIC NP NP 9 TCGA-24-2281-01 OVARY c.789C>T p.T263T COSMIC NP NP 10 TCGA-33-4532-01 LUNG c.346G>A p.D116N COSMIC PASSENGER/OTHER Probably Damaging 11 TCGA-36-2538-01 OVARY c.1002G>A p.E334E COSMIC NP NP 12 TCGA-66-2768-01 LUNG c.265G>T p.A89S COSMIC PASSENGER/OTHER Probably Damaging 13 TCGA-A6-6649-01 LARGE INTESTINE c.23G>A p.G8E COSMIC PASSENGER/OTHER Probably Damaging 14 TCGA-C8-A12W-01 BREAST c.137G>A p.S46N COSMIC PASSENGER/OTHER Benign 15 TCGA-CJ-4905-01 KIDNEY c.107A>T p.E36V COSMIC PASSENGER/OTHER Benign 16 TCGA-F4-6460-01 LARGE INTESTINE c.483C>T p.A161A COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
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Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
