dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SIRT7 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587342 LARGE INTESTINE c.1008G>A p.W336* COSMIC NP NP 2 CCRF-CEM HAEMATOPOIETIC AND LYMPHOID TISSUE c.359delG p.G121fs*20 COSMIC NP NP 3 ESO-161 OESOPHAGUS c.869G>A p.R290Q COSMIC PASSENGER/OTHER Probably Damaging 4 ESO-859 OESOPHAGUS c.595G>A p.V199I COSMIC PASSENGER/OTHER Benign 5 HCC48T LIVER c.613G>T p.V205L COSMIC PASSENGER/OTHER Benign 6 HCT-116 LARGE INTESTINE c.644C>T p.A215V COSMIC PASSENGER/OTHER Possibly Damaging 7 HN_62426 UPPER AERODIGESTIVE TRACT c.1025C>G p.S342* COSMIC NP NP 8 LC_C15 LUNG c.1042C>T p.R348C COSMIC PASSENGER/OTHER Benign 9 LUAD-E00934 LUNG c.192G>T p.R64R COSMIC NP NP 10 PD4120a BREAST c.499C>G p.Q167E COSMIC PASSENGER/OTHER Probably Damaging 11 TCGA-05-5425-01 LUNG c.426G>A p.E142E COSMIC NP NP 12 TCGA-29-1785-01 OVARY c.774C>A p.A258A COSMIC NP NP 13 TCGA-37-4141-01 LUNG c.1022T>G p.F341C COSMIC PASSENGER/OTHER Probably Damaging 14 TCGA-50-6590-01 LUNG c.790A>T p.I264F COSMIC PASSENGER/OTHER Probably Damaging 15 TCGA-55-7574-01 LUNG c.31C>T p.R11C COSMIC PASSENGER/OTHER Probably Damaging 16 TCGA-66-2789-01 LUNG c.803G>T p.G268V COSMIC CANCER Probably Damaging 17 TCGA-75-5126-01 LUNG c.617_618GG>TT p.R206L COSMIC PASSENGER/OTHER Probably Damaging 18 TCGA-AA-A01R-01 LARGE INTESTINE c.1042C>T p.R348C COSMIC PASSENGER/OTHER Benign 19 TCGA-AP-A059-01 ENDOMETRIUM c.1031C>T p.A344V COSMIC PASSENGER/OTHER Possibly Damaging 20 TCGA-AP-A059-01 ENDOMETRIUM c.1178G>A p.R393H COSMIC PASSENGER/OTHER Possibly Damaging 21 TCGA-AP-A0LM-01 ENDOMETRIUM c.941A>C p.K314T COSMIC PASSENGER/OTHER Benign 22 TCGA-AP-A0LT-01 ENDOMETRIUM c.616C>T p.R206W COSMIC PASSENGER/OTHER Probably Damaging 23 TCGA-AR-A24Q-01 BREAST c.1076C>G p.S359W COSMIC PASSENGER/OTHER Probably Damaging 24 TCGA-B4-5835-01 KIDNEY c.41C>T p.A14V COSMIC PASSENGER/OTHER Possibly Damaging 25 TCGA-B5-A0JY-01 ENDOMETRIUM c.973G>A p.E325K COSMIC PASSENGER/OTHER Benign 26 TCGA-B5-A11E-01 ENDOMETRIUM c.1042C>T p.R348C COSMIC PASSENGER/OTHER Benign 27 TCGA-B8-5164-01 KIDNEY c.14G>A p.G5D COSMIC PASSENGER/OTHER Benign 28 TCGA-BG-A0MU-01 ENDOMETRIUM c.729G>A p.G243G COSMIC NP NP 29 TCGA-BH-A0BW-01 BREAST c.700G>T p.D234Y COSMIC PASSENGER/OTHER Probably Damaging 30 TCGA-C8-A273-01 BREAST c.233T>G p.V78G COSMIC PASSENGER/OTHER Probably Damaging 31 TCGA-CA-6717-01 LARGE INTESTINE c.1185A>C p.K395N COSMIC PASSENGER/OTHER Probably Damaging 32 TCGA-CH-5767-01 PROSTATE c.414C>T p.A138A COSMIC NP NP 33 TCGA-CM-5861-01 LARGE INTESTINE c.952G>A p.V318I COSMIC PASSENGER/OTHER Probably Damaging 34 TCGA-E9-A22G-01 BREAST c.762G>C p.A254A COSMIC NP NP 35 ccRCC-78 KIDNEY c.433C>G p.P145A COSMIC PASSENGER/OTHER Probably Damaging
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Variants are not present in 1000 Genomes!!2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
