dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SMARCD3 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 090 HAEMATOPOIETIC AND LYMPHOID TISSUE c.1012G>A p.D338N COSMIC NP NP 2 090-02-1TD HAEMATOPOIETIC AND LYMPHOID TISSUE c.1012G>A p.D338N COSMIC NP NP 3 587260 LARGE INTESTINE c.745C>T p.Q249* COSMIC NP NP 4 587332 LARGE INTESTINE c.1056G>T p.E352D COSMIC NP NP 5 587376 LARGE INTESTINE c.569C>A p.S190Y COSMIC NP NP 6 CA3 LARGE INTESTINE c.800G>A p.R267H COSMIC NP NP 7 Case5 OVARY c.1078A>T p.S360C COSMIC NP NP 8 H2009 LUNG c.481G>C p.D161H COSMIC NP NP 9 H2009 LUNG c.730G>A p.D244N COSMIC NP NP 10 HCC139T LIVER c.319C>A p.Q107K COSMIC NP NP 11 HX12T LIVER c.857C>A p.S286Y COSMIC NP NP 12 LUAD-RT-S01702 LUNG c.669C>T p.D223D COSMIC NP NP 13 LUAD-RT-S01770 LUNG c.1080C>T p.S360S COSMIC NP NP 14 NCI-H2009 LUNG c.481G>C p.D161H COSMIC NP NP 15 OV207 OVARY c.1402C>T p.R468C COSMIC NP NP 16 PGBM11PT CENTRAL NERVOUS SYSTEM c.27delC p.T10fs*125 COSMIC NP NP 17 T155 ENDOMETRIUM c.465G>A p.A155A COSMIC NP NP 18 TARGET-30-PATESI AUTONOMIC GANGLIA c.669C>T p.D223D COSMIC NP NP 19 TCGA-13-0885-01 OVARY c.844A>T p.R282W COSMIC NP NP 20 TCGA-29-1693-01 OVARY c.942G>T p.Q314H COSMIC NP NP 21 TCGA-37-3789-01 LUNG c.465G>T p.A155A COSMIC NP NP 22 TCGA-44-2656-01 LUNG c.463G>T p.A155S COSMIC NP NP 23 TCGA-91-6847-01 LUNG c.1335C>T p.A445A COSMIC NP NP 24 TCGA-95-7947-01 LUNG c.521A>C p.E174A COSMIC NP NP 25 TCGA-A6-6648-01 LARGE INTESTINE c.740C>T p.P247L COSMIC NP NP 26 TCGA-AA-3516-01 LARGE INTESTINE c.514C>T p.R172W COSMIC NP NP 27 TCGA-AA-3710-01 LARGE INTESTINE c.670G>A p.G224S COSMIC NP NP 28 TCGA-AA-3864-01 LARGE INTESTINE c.1028C>T p.A343V COSMIC NP NP 29 TCGA-AA-A010-01 LARGE INTESTINE c.465G>A p.A155A COSMIC NP NP 30 TCGA-AD-5900-01 LARGE INTESTINE c.412A>G p.M138V COSMIC NP NP 31 TCGA-AG-3612-01 LARGE INTESTINE c.1392G>A p.S464S COSMIC NP NP 32 TCGA-AG-3892-01 LARGE INTESTINE c.465G>A p.A155A COSMIC NP NP 33 TCGA-AN-A0AS-01 BREAST c.1363delC p.Q455fs*>16 COSMIC NP NP 34 TCGA-AP-A051-01 ENDOMETRIUM c.1213G>T p.G405C COSMIC NP NP 35 TCGA-AP-A059-01 ENDOMETRIUM c.992T>G p.V331G COSMIC NP NP 36 TCGA-AX-A05Z-01 ENDOMETRIUM c.428A>C p.K143T COSMIC NP NP 37 TCGA-AX-A05Z-01 ENDOMETRIUM c.579G>T p.K193N COSMIC NP NP 38 TCGA-AX-A0J1-01 ENDOMETRIUM c.1297C>T p.R433W COSMIC NP NP 39 TCGA-AY-6196-01 LARGE INTESTINE c.844A>G p.R282G COSMIC NP NP 40 TCGA-AZ-6598-01 LARGE INTESTINE c.987C>T p.N329N COSMIC NP NP 41 TCGA-B5-A0JY-01 ENDOMETRIUM c.1146G>A p.T382T COSMIC NP NP 42 TCGA-B5-A11E-01 ENDOMETRIUM c.981C>T p.V327V COSMIC NP NP 43 TCGA-BH-A18U-01 BREAST c.932A>G p.E311G COSMIC NP NP 44 TCGA-BS-A0UV-01 ENDOMETRIUM c.486C>T p.S162S COSMIC NP NP 45 TCGA-CI-6619-01 LARGE INTESTINE c.800G>A p.R267H COSMIC NP NP 46 TCGA-CK-5915-01 LARGE INTESTINE c.844A>G p.R282G COSMIC NP NP 47 TCGA-CM-6162-01 LARGE INTESTINE c.1295G>A p.R432H COSMIC NP NP 48 TCGA-D1-A16X-01 ENDOMETRIUM c.424C>T p.R142W COSMIC NP NP 49 TCGA-DI-A0WH-01 ENDOMETRIUM c.1111_1113delGAG p.E371delE COSMIC NP NP 50 TCGA-E2-A1B0-01 BREAST c.1130G>A p.S377N COSMIC NP NP 51 TCGA-GV-A3QI-01 URINARY TRACT c.414G>A p.M138I COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
