dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SMYD3 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 2334196 LUNG c.754G>T p.A252S COSMIC NP NP 2 587246 LARGE INTESTINE c.127G>A p.V43I COSMIC NP NP 3 587316 LARGE INTESTINE c.908T>C p.F303S COSMIC NP NP 4 HCC56T LIVER c.510C>A p.I170I COSMIC NP NP 5 LUAD-5V8LT LUNG c.795C>T p.N265N COSMIC NP NP 6 LUAD-YINHD LUNG c.1078G>C p.E360Q COSMIC NP NP 7 LUAD-YINHD LUNG c.466G>T p.V156L COSMIC NP NP 8 TCGA-05-4432-01 LUNG c.1045C>A p.H349N COSMIC NP NP 9 TCGA-22-1012-01 LUNG c.643G>A p.D215N COSMIC NP NP 10 TCGA-39-5021-01 LUNG c.75G>A p.K25K COSMIC NP NP 11 TCGA-46-3765-01 LUNG c.531C>A p.T177T COSMIC NP NP 12 TCGA-49-6744-01 LUNG c.166G>A p.G56R COSMIC NP NP 13 TCGA-55-6968-01 LUNG c.840C>G p.I280M COSMIC NP NP 14 TCGA-55-7907-01 LUNG c.391A>T p.M131L COSMIC NP NP 15 TCGA-91-6848-01 LUNG c.920A>G p.H307R COSMIC NP NP 16 TCGA-A2-A0EM-01 BREAST c.1040G>A p.R347K COSMIC NP NP 17 TCGA-A2-A0YK-01 BREAST c.528C>T p.L176L COSMIC NP NP 18 TCGA-A3-3346-01 KIDNEY c.79G>A p.E27K COSMIC NP NP 19 TCGA-A3-3346-01 KIDNEY c.83G>A p.C28Y COSMIC NP NP 20 TCGA-A8-A09I-01 BREAST c.301C>T p.Q101* COSMIC NP NP 21 TCGA-AA-3966-01 LARGE INTESTINE c.1086C>T p.C362C COSMIC NP NP 22 TCGA-AA-A00N-01 LARGE INTESTINE c.167G>T p.G56V COSMIC NP NP 23 TCGA-AA-A010-01 LARGE INTESTINE c.1081G>T p.E361* COSMIC NP NP 24 TCGA-AG-A002-01 LARGE INTESTINE c.178G>T p.E60* COSMIC NP NP 25 TCGA-AG-A002-01 LARGE INTESTINE c.505G>A p.D169N COSMIC NP NP 26 TCGA-AP-A0LD-01 ENDOMETRIUM c.368_369delCT p.S123fs*5 COSMIC NP NP 27 TCGA-AP-A0LM-01 ENDOMETRIUM c.381T>C p.C127C COSMIC NP NP 28 TCGA-AP-A0LM-01 ENDOMETRIUM c.98G>T p.S33I COSMIC PASSENGER/OTHER Possibly Damaging 29 TCGA-B5-A0JY-01 ENDOMETRIUM c.450C>T p.D150D COSMIC NP NP 30 TCGA-B5-A0JY-01 ENDOMETRIUM c.701T>G p.I234S COSMIC NP NP 31 TCGA-B6-A0I2-01 BREAST c.443G>T p.S148I COSMIC NP NP 32 TCGA-BT-A20R-01 URINARY TRACT c.798C>G p.I266M COSMIC NP NP 33 TCGA-EY-A1GS-01 ENDOMETRIUM c.1037G>T p.G346V COSMIC NP NP 34 TCGA-F4-6570-01 LARGE INTESTINE c.700_701insA p.I234fs*2 COSMIC NP NP 35 TCGA-G4-6304-01 LARGE INTESTINE c.21C>T p.R7R COSMIC NP NP 36 cSCCP7 SKIN c.418C>T p.P140S COSMIC NP NP 37 pfg016T STOMACH c.764G>A p.S255N COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.Gene essentiality data is not present in COLT database!! -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB -
Structure Domains (+)
1. PFAM domains are not present!!2. Superfaimly domains are not present!! -
Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:4. Sequence alignment with homologus proteins: -
Sequence Profiles (+)
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Post Translational Modifications (+)
Post translational modifications are not found!!Other Databases Link (+)
