dbEM
A Database of Epigenetic Modifiers
Cite: Nanda JS, Kumar R, Raghava GP. (2016) dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes. Sci Rep. 6:19340.
Protein: SMYD5 |
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Mutation Data (+)
# Cell Line/Tumor sample Tissue of Origin cDNA change Protein change Source FATHMM Prediction PolyPhen2 Prediction 1 587226 LARGE INTESTINE c.108G>T p.Q36H COSMIC NP NP 2 587376 LARGE INTESTINE c.76G>A p.D26N COSMIC NP NP 3 8012210 PANCREAS c.619G>C p.E207Q COSMIC NP NP 4 ESOSCC162T OESOPHAGUS c.743G>A p.R248H COSMIC NP NP 5 HN_00190 UPPER AERODIGESTIVE TRACT c.124A>T p.I42F COSMIC PASSENGER/OTHER Benign 6 ICGC_0025 PANCREAS c.619G>C p.E207Q COSMIC NP NP 7 ME049T NS c.719A>C p.Q240P COSMIC NP NP 8 S01366 LUNG c.233G>A p.C78Y COSMIC NP NP 9 TCGA-05-4432-01 LUNG c.280G>T p.G94* COSMIC NP NP 10 TCGA-55-6712-01 LUNG c.196G>C p.D66H COSMIC NP NP 11 TCGA-60-2698-01 LUNG c.841G>T p.E281* COSMIC NP NP 12 TCGA-A6-5665-01 LARGE INTESTINE c.331G>T p.A111S COSMIC NP NP 13 TCGA-AA-3554-01 LARGE INTESTINE c.22C>T p.R8W COSMIC NP NP 14 TCGA-AA-3663-01 LARGE INTESTINE c.774_777delTGTC p.C260fs*14 COSMIC NP NP 15 TCGA-AD-6964-01 LARGE INTESTINE c.277C>A p.L93M COSMIC NP NP 16 TCGA-AG-A002-01 LARGE INTESTINE c.616G>T p.A206S COSMIC NP NP 17 TCGA-AG-A002-01 LARGE INTESTINE c.734G>A p.R245H COSMIC NP NP 18 TCGA-AP-A056-01 ENDOMETRIUM c.852G>A p.E284E COSMIC NP NP 19 TCGA-AP-A0LM-01 ENDOMETRIUM c.529G>A p.E177K COSMIC NP NP 20 TCGA-AX-A05Z-01 ENDOMETRIUM c.762G>T p.E254D COSMIC NP NP 21 TCGA-D1-A17R-01 ENDOMETRIUM c.380G>A p.R127Q COSMIC NP NP 22 TCGA-FD-A3N6-01 URINARY TRACT c.69C>T p.P23P COSMIC NP NP
*NP: Not Predicted -
Copy number variation and expression profile (+)
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Gene Essentiality Data (+)
Note: Lower the GARP score (more negative), higher the essentiality of the gene. P-value tells about the significane of GARP score.test -
Tertiary structure (+)
Users must enabled the Java in their browser to see structure.
Users can also download Java from here.Modelled Structure Structures available in PDB Structure is not available in PDB -
Structure Domains (+)
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Sequence Alignment (+)
Users must enabled the Java in their browser to see sequence alignments.
Users can also download Java from here.1. Sequence alignment with 1000 genome variations:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 2. Mutants are not present in CCLE!!3. Sequence alignment with COSMIC mutants:
Click on button to get Sequence alignment with Coverage, Consensus and Quality 4. Sequence alignment with homologus proteins:
Click on button to get Sequence alignment with Coverage, Consensus and Quality -
Sequence Profiles (+)
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Post Translational Modifications (+)
S. No. Position Amino acid Type 1 207 K Ubiquitylation -
Other Databases Link (+)
Proteomics DB COSMIC Gene Atlas STRING PIR SMYD5 SMYD5 SMYD5 ENSP00000374152 Q6GMV2 QuickGO HGNC Ensembl Genome Browser TreeFam UniProt Q6GMV2 SMYD5 ENSP00000374152 SMYD5 Q6GMV2 Expression Atlas Protein Atlas OMIM IntAct PharmGKB SMYD5 ENSP00000374152 NA Q6GMV2 PA34190
